Programa de Pós-Graduação em Farmacologia e Química Medicinal
Artigos em periódicos
2021
Lorenzoni, R.; Contri, R.V.; Lima, C. K. F.; Barreto, F. ; Araujo, B. V.; Pohlmann, A.R. ; Miranda, A.L.P. ; Costa, T.D. ; Guterres, S.S . Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal of Pharmaceutics, v. 596, p. 120294, 2021.
Doi: 10.1016/j.ijpharm.2021.120294
Robba, C.; Battaglini, D. ; Ball, L.; Valbusa, A. ; Porto, I. ; Bona, R.D.; Malfa, G. ; Patroniti, N. ; Brunetti, I. ; Loconte, M. ; Bassetti, M. ; Giacobbe, D. R. ; Vena, Antonio ; Silva, C.L. M. ; Rocco, P. R. M. ; Pelosi, P. Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine, v. 10, p. 140, 2021.
Doi: 10.3390/jcm10010140
Santana, M. V. S. ; Silva, F. P. De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning. BMC Chemistry, v. 15, p. 8, 2021.
Doi:10.1186/s13065-021-00737-2
Silva, J. S. ; Montagnoli, T. L. ; Rocha, B. S. ; Tacco, M. L. C. A. ; Marinho, S. C. P. ; Sudo, G.Z . Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction. International Journal of Molecular Sciences, v. 22, p. 525, 2021.
Alencar, A. K.N. ; Wang, H. ; Oliveira, G. M.M. ; Sun, X. ; Sudo, G.Z. ; Groban, L. Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction. Arquivos Brasileiros de Cardiologia (eletronic), p. 1, 2021.
Silva, J. ; Thompson'souza, G. A. ; Barroso, Marina Valente ; Neves, J. S. ; Figueiredo, R. T. Neutrophil and eosinophil DNA extracellular trap formation: lessons from pathogenic fungi. Frontiers in Microbiology, 2021.
Barroso, M.V. ; Gropillo, I. ; Detoni, M. ; Thompson'souza, G. A. ; Vasconcelos, C. I. ; Muniz, V. S. ; Figueiredo, R. T. ; Melo, R. C N ; Neves, J. S. Signaling events driving Aspergillus fumigatus-induced human eosinophils extracellular trap release. Frontiers in Microbiology, 2021.
Couto, J.; Simas, D. ; Silva, M. ; Barth, T. ; Pinto, S.; Tinoco, L.W. ; Freire, D.; Muzitano, M. ; Leal, I. HSCCC Separations of Rutin Esters Obtained by Enzymatic Reaction Catalyzed by Lipase. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2021.
Doi: 10.21577/0103-5053.20200206
Silveira, F. F.; Souza, J. O.; Hoelz, L. V.B. ; Campos, V. R. ; Jabor, V. A.P. ; Aguiar, A. C.C. ; Nonato, M. C. ; Albuquerque, M. G. ; Guido, R. V.C. ; Boechat, N. ; Pinheiro, L.C.S. Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors. European Journal of Medicinal Chemistry, v. 209, p. 112941, 2021.
Doi:10.1016/j.ejmech.2020.112941
Dias, F.; Guerra, F.; Lima, F. ; Castro, Y. ; Ferreira, V. ; Campos, V. ; Fernandes, P. ; Cunha, A. Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents. Journal of the Brazilian Chemical Society, v. 1, p. 1-14, 2021.
Doi.org/10.21577/0103-5053.20200202.
Carvalho, P.R.; Sirois, P.; Fernandes, P.D. The role of kallikrein-kinin and renin-angiotensin systems in COVID-19 infection. Peptides, v. 135, p. 170428, 2021.
Doi.org/10.1016/j.peptides.2020.170428
Junior, A.T.F.; Anjos, F.F.; Brito, F. C. M. ; Viana, V.G.F. ; Valença, S.S. ; Lanzetti, M. ; Finotelli, P.V. Bixin loaded on polymeric nanoparticles: synthesis, characterization, and antioxidant applications in a biological system. Applied Nanoscience, v. 11, p. 63-78, 2021.
Doi: 10.1007/s13204-020-01555-z
2020
Franco, L.S.; Maia, R.C.; Barreiro, E.J. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (MPRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model. RSC Medicinal Chemistry. 12, 110–119.
Silva, N. L. C.; Mota, N. A. V. ; Soares, M. A. ; Araujo, O.M.O.; Espindola, L. C. P. ; Colombo, A. P. V. ; Lopes, R. T. ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.
Doi: 10.1111/jre.12730
Rodrigues, D. A.; Pinheiro, P.S.M. ; Sagrillo, F.S. ; Freitas, M.C.R. ; Alves, M.A, ; Thota, S. ; Tinoco, L.W. ; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-Property Relationship Studies of 3-Acyl-Substituted Furans: The Serendipitous Identification and Characterization of a New Non-Classical Hydrogen Bond Donor Moiety. New Journal of Chemistry, v. 44, p. 10994-11005, 2020.
Doi.org/10.1039/D0NJ01598A
Rodrigues, D. A ; Pinheiro, P. S. M. ; Sagrillo, F. S. ; Bolognesi, M. L. ; FRAGA, C. A. M. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Medicinal Research Reviews, v. 40, p. 2177-2211, 2020.
Doi: 10.1002/med.21701
Cunha, T.T.S.; Souza, F. R.; Pinheiro, P. S.M.; Sant’anna, C. M.R.; NOËL, F.; França, T.C. C.; Fraga, C.A.M. Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin. CNS & Neurological Disorders-Drug Targets, v. 19, p. 437-447, 2020.
Doi: 10.2174/1871527319999200817153150
Viegas, C. ; Fraga, C. A. M.; Sousa, M. E. ; Tarozzi, A . Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?. Frontiers in Pharmacology, v. 11, p. 609274, 2020.
Thorstenberg, M. L. ; Martins, M. D. A. ; Figliuolo, V. ; Silva, C.L. M ; Savio, L.E. ; Silva, R.C . P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion. Mediators of Inflammation, v. 2020, p. 1-11, 2020.
Oliveira, N.F.; Silva, C.L.M. Unveiling the potential of purinergic signaling in schistosomiasis treatment. Current Topics in Medicinal Chemistry, v. 20, p. 1, 2020.
Doi: 10.2174/1568026620666200924115113
Teixeira, R. G. S.; Pascual, R.; Araújo, K.G.L.; Brito, M. A. ; RIOS, C. ; C., A. F. ; Gandía, L. ; Silva, C. L. M. ; Machado, T. B. ; Santos, Wilson,C. In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone. Natural Product Research. V. 1, p. 1-6, 2020.
Doi: 10.1080/14786419.2020.1739675
Pauli, F. P.; Martins, J. R.; Paschoalin, T. ; Ionta, M. ; Barbosa, M. L. C. ; Barreiro, E. J. Novel VEGFR-2 inhibitors with an N</i> -acylhydrazone scaffold. Archiv Der Pharmazie, v. 276, p. e2000130., 2020.
Alves, M. A.;Queiroz, A. C. ; Leite, A. B. ; Martins, F.T. ; Doriguetto, A. C. ; Barreiro, E. J. ; Moreira, M. S. A. ; Lima, L. M. Carbamoyl- N</i> -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.
Pedreira, J. G. B.; Nahidino, P.; Kudolo, M.; Pantsar, T.; Berger,B.T. ; Forster, M. ; Knapp, S.; Laufer, S. ; Barreiro, E. J. Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 alpha MAP Kinase Inhibitors. Journal Of Medicinal Chemistry, v. 63, p. 7347-7354, 2020.
Doi:10.1021/acs.jmedchem.0c00508
Colodette, N. M.; Franco, L. S.; Maia, Rodolfo C.; Fokoue, H. H.; Sant’anna, C. M. R.; Barreiro, E. J. Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models. Journal Of Computer-aided Molecular Design, v. 34, p. 1091-1103, 2020.
Doi:10.1007/s10822-020-00327-9
Lima, L. M. ; Silva, B. N. M.; Barbosa, G. ; Barreiro, E. J. β-lactam antibiotics: An overview from a medicinal chemistry perspective. European Journal Of Medicinal Chemistry, v. 208, p. 112829, 2020.
Doi:10.1016/j.ejmech.2020.112829
Senger, M. R. ; Evangelista, T. C. S. ; Dantas, R. F. ; Santana, M. V. S. ; Gonçalves, L. C. S.; Neto, L. R.S. ; Ferreira, S. B. ; Junior, F. P.S . COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, v. 115, p. 1, 2020.
Doi.org/10.1590/0074-02760200254
Neto, L.R.S.; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in Chemistry, v. 8, p. 1-18, 2020.
Doi.org/10.3389/fchem.2020.00093
Issy A.C.; Pedrazzi, J. F. C.; Van Oosten, A. B. S.; Checheto, T.; Silva, R. R.; Noel, F.; Del-bel, E. Effects of doxycycline in Swiss mice predictive models of schizophrenia. Neurotoxicity Research, v. 101007, p. s1264002000268z, 2020.
Doi: 10.1007/s12640-020-00268-z
Silva, M. M. C.; Alencar, Nogueira, A.K.; Silva, J.S.; Montagnoli, T.L.; Silva, G.F.; Rocha, B.S.; Montes, G.C.; Otero, R.M.; Coelho, P.M.P.; Vasques, J. F.; Trahez, M.M.; Sudo, R.T.; Sudo, G.Z. Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, v. 9, p. 2120, 2020.
Borsoi, M. ; Nunes, L. E. D. ; Barbosa, A. R. ; Lima, M. S. ; Medeiros, I. ; Pranke, M. A. ; Antonio, C. B. ; RATES, S. M. K. ; Neves, G.A. Intermittent repeated stress but not ketamine changes mice response to antidepressants. Neuroscience Letters, p. 135452, 2020.
Doi: 10.1016/j.neulet.2020.135452
Silva, J. C.; Rodrigues, N. C.; Thompson'souza, G. A.; Muniz, V. S.; Neves, J. S.; Figueiredo, R. T. Mac-1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination. Journal of Leukocyte Biology, v. 107, p. 69-83, 2020.
Nino, O. M.; Costa, C. S.; Torres, K. M.; Zanol, J. F.; Lima, L. C. F.; Alves, L.M.; Graceli, J. B. High refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats. Toxicology Letters, v. 332, p. 42-55, 2020.
Doi.org/10.1016/j.toxlet.2020.07.002
Graceli, J. B.; Dettogni, R. S.; Merlo, E.; Nino, O. M.; Costa, C. S.; Zanol, J. F.; Morris, E. A. R. ; Alves, L.M. ; Denicol, A. C. The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Molecular and Cellular Endocrinology, v. 518, p. 110997-111017, 2020.
Doi.org/10.1016/j.mce.2020.110997
Junior, N. C.L.; Camilo, J. F.; Carmo, P. R.; Andrade, M. N.; Braz, B. F.; Santelli, R. E.; Gitirana, L. B.; Ferreira, A. C. F. ; Carvalho, D. P. ; Alves, L.M. ; Dias, G. R. M. Subacute Exposure to Lead Promotes Disruption in the Thyroid Gland Function in Male and Female Rats. Environmental Pollution, 2020.
Doi:10.1016/j.envpol.2020.115889
Chagas, A.P.; Peixoto, B.P.; Costa, B.B.; Moreira, T.A.; Cinelli, L.P.; Silva, L.L.; Alves, L.M.; Junior, C.B. Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic. Toxicology Mechanisms and Methods, v. 31, p. 1-34, 2020.
Doi:10.1080/15376516.2020.1836102
Almeida, J.; Oliveira, V.R.; Avelar, J.L.S.; Moita, B.S.; Lima, L.M. COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química, 2020, 12 (6), 1464-1497.
Curnow, A. C.; Gonsalez, S. R.; Gogulamudi, V. R.; Visniauskas, B. ; Simon, E. E. ; Gonzalez, A. A. ; Majid, D. S. A. ; Lara, L.S. ; Prieto, M. C. Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct. Frontiers in Physiology, v. 11, p. 153, 2020.
Doi.org/10.3389/fphys.2020.559341
Ortiz, M.; Coutinho, D. S.; Ciambarella, B. T.; Souza, E.; Leite, A. P.; Durli, T. L.; Silva, P. M. R.; Bernardi, A.; Sonvico, F.; Pohlmann, A. R.; Martins, M. A.; Guterres, S. S. Intranasal administration of budesonide-loaded nanocapsule-microagglomerates as an innovative strategy for asthma treatment. Drug Delivery and Translational Research, 2020.
Doi.org/10.1007/s13346-020-00813-5
Coutinho, D. S.; Pires, J.; Gomes, H.; Pohlmann, A.; Guterres, S.; Silva, P. M. R. E.; Ferrarini, S.; Bernardi, A.; Martins, M.A. Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice. Pharmaceutics, v. 12, p. 1075, 2020.
Doi: 10.3390/pharmaceutics12111075.
Insuela, D. B. R.; Ferrero, M.R.; Coutinho, D. S.; Martins, M. A.; Carvalho, V. F. Could Arachidonic Acid-Derived Pro-Resolving Mediators Be a New Therapeutic Strategy for Asthma Therapy?. Frontiers in Immunology, v. 11, p. 1-9, 2020.
Mello, F.V.C.; Quaresma, B.M.C.S.; Pitombeira, M.C.R.; Brito, M.A.; Farias, P.P.; Castro, S.L.; Salomão, K.; Carvalho, A.S.; Paula, J.I.O.; Nascimento, S.B.; Cupello, M.P.; Paes, M.C; Boechat, N.; Felzenszwalb, Israel . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European Journal of Medicinal Chemistry, v. 186, p. 111887-111902, 2020.
Boechat, N.; Carvalho, R. C.C. ; Ferreira, M.L. G. ; Coutinho, J.P.; Sa, P.M. ; Seito, L. N. ; Rosas, E. C. ; Krettli, A.U. ; Bastos, M. M. ; Pinheiro, L. C.S. Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. Bioorganic & Medicinal Chemistry, v. 28, p. 115832-115846, 2020.
Doi: 10.1016/j.bmc.2020.115832.
Pinheiro, L.C.S.; Hoelz, L.V.B.; Ferreira, M.L.G.; Oliveira, L.G.; Pereira, R.F.A.; Valle, A.M.; André, L.S.P.; Scaffo, J.; Pinheiro, F.R.; Ribeiro, T.A.N.; Sachs, D.; Pascoal, A.C.R.F.; Boechat, N.; Aguiar'alves, F. Synthesis of benzoylthiourea derivatives and analysis of their antibacterial performance against planktonic Staphylococcus aureus and its biofilms. Letters in Applied Microbiology, v. 71, p. 645-651, 2020.
Souza, A. A. A. ; Torres, L. R. ; Capobianco, L. R. P. L. ; Paula, V. S. ; Cascabulho, C. M. ; Salomao, K. ; Almeida, M. G. B. ; Ferreira, M.L G. ; Boechat, N. ; Pinheiro, L. C. S. ; Souza, E. M. Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells. Viruses-Basel, v. 13, p. 1-15, 2020.
Doi: 10.3390/v13010036.
Martins, D.L.; Borges, A.A.; Silva, N. A.; Faria, J.V.; Hoelz, L.V.B.; Souza, H.V.C.M.; Bello, M.L.; Boechat, N.; Ferreira, V.F.; Faria, R.X. P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones. Bioorganic Chemistry, v. 104, p. 104278-104289, 2020.
Doi: 10.1016/j.bioorg.2020.104278.
Ferreira, T. P. T.; JG, Lima; Filho, F.F. ; SA, Y. A. P. J. ; AC, Arantes ; Guimaraes, F. V. ; V, Carvalho ; Hogaboam, C M ; J, Wallace ; Martins, M. A. ; Silva, PM . Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Frontiers in Endocrinology, v. 11, p. 388, 2020.
Ventura, R. D. ; Chaves, A. S. ; Magalhaes, N. S. ; Gonzalez, F. B. ; Pacini, M. F. ; Perez, A. R. ; Silva, P. M. R. ; M.A., Martins ; VF, Carvalho . Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. Free Radical Biology and Medicine, v. 156, p. 137-143, 2020.
Nunes, I. K. C.; Souza, E. T.; Martins, I. R. R.; Barbosa, G. ; Junior, M. O. M.; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, Carvalho ; Martins, M. A. ; Lima,L.M . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.
Doi: 10.1016/j.ejmech.2020.112492.
Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S. ; Silva, E.T. ; Souza, M.V. N.; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A. Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology, v. 11, p. 1159, 2020.
Doi.org/10.3389/fphar.2020.01159
Cavalieri,I.C.P.; Valenca, H. M. ; Moraes, J.A. ; Gitirana, L.B.; Souza, B.R. ; Schmidt, M ; Valença, S.S . Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice. International Journal of Molecular Sciences, v. 21, p. 9658, 2020.
Nascimento, M.S.S. ; Câmara, V.R.F. ; Costa, J.S. ; Barbosa, J.M.C. ; Lins, A.S.M. ; Salomão, K. ; Castro, S.L.; Carvalho, S.A. ; Silva, E.F. ; Ferreira. E.; ; Fraga, C.A.M. Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates. Medicinal Chemistry , v. 16, p. 774-783, 2020.
Doi:10.2174/1573406415666190627103013
Araujo-montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; Silva-jr, F.P. Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells. Protein Expression and Purification, v. 167, p. 105532, 2020.
Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical Pharmacology , v. 171, p. 113679, 2020.
Doi: 10.1016/j.bcp.2019.113679
Costa, G. ; Montagnoli, T. L. ; Da SILVA, J. S. ; Alencar, A. K. N. ; Gamba, L. E.R. ; Alves, B. E.O. ; Moraes, M. C. ; Trachez, M. M ; Nascimento, J. H.M. ; Coelho, P.M.P. ; Mendez-otero, R. ; Lima, L.M. ; Barreiro, E.J. ; Sudo, Roberto Takashi ; Sudo, G.Z . New benzofuran N-acylhydrazone reduces cardiovascular dysfunction in obese rats by blocking TNF-alpha synthesis. Drug Design Development and Therapy , v. 14, p. 3337-3350, 2020.
Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Selmi-ruby, S. ; Maximo, V. ; Soares, P. ; Alves, L. M. Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and Cellular Endocrinology , v. 502, 2020.
Doi: 10.1016/j.mce.2019.110677
3.
Reis, E.M. ; Nobre, C. C. G. ; Chagas, A.P. ; Alves, L.M. ; Junior, C.B . Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2020.
Doi: 10.23937/2469-5696/1410048
Lindoso, RS ; Lopes, J.A. ; Binato, R. ; Abdelhay, E. ; Takiya, C.M. ; Miranda, K.R. ; Lara, L. S. ; Viola ,A ; Bussolati, B ; Vieyra, A. ; Collino F . Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection. Molecular Therapy-Methods & Clinical Development, v. 16, p. 63-77, 2020.
Doi:10.1016/j.omtm.2019.11.002
Dick, C. F. ; Guimarães, L.M. ; Kelly, L.F.C. ; Cortes, A.L. ; Morcillo, L.L.S. ; Sampaio, L.S. ; Fernandes, J. R.M. ; Vieyra, A. . A ferric reductase of Trypanosoma cruzi (TcFR) is involved in iron metabolism in the parasite. Experimental Parasitology, v. 217, p. 107962, 2020.
Doi:10.1016/j.exppara.2020.107962
Lima, J. A. ; R. Costa, T.W. ; Fonseca, A. C.C. ; Amaral, R. F. ; Nascimento, M.D. S.B. ; Filho, O.A.S. ; Miranda, A.L.P. ; Neto, D.C.F.; Lima, F.R.S. ; Hamerski, L. ; Tinoco, L. W. Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorganic chemistry, v. 104, p. 104215, 2020.
Nunes, I.C.N. ; Souza, E.T. ; Martins, I.R.M. ; Barbosa, G. ; Junior, M.O.N. ; Medeiros, M.M. ; Silva, S. W.D. ; Balliano, T.L.; Silva, B.A. ; Silva, P.M.R.; Carvalho, V.F. ; Martins, M.A.; Lima, L.M. Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 204, p. 112492, 2020.
DOI: 10.1016/j.ejmech.2020.112492
Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S.; Silva, E.T.; Souza, M.V.N. ; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A . Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology , v. 11, p. 1159, 2020.
Doi.: 10.3389/fphar.2020.01159
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