Artigos em periódicos

 

2020

 

 

Nascimento, M.S.S. ; Câmara, V.R.F. ; Costa, J.S. ; Barbosa, J.M.C. ; Lins, A.S.M. ; Salomão, K. ; Castro, S.L.; Carvalho, S.A. ; Silva, E.F. ; Ferreira. E.;  ; Fraga, C.A.M. Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates. Medicinal Chemistry , v. 16, p. 774-783, 2020.

 

Doi:10.2174/1573406415666190627103013

Araujo-montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; Silva-jr, F.P.  Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells. Protein Expression and Purification, v. 167, p. 105532, 2020.

 

Doi:10.1016/j.pep.2019.105532

Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical Pharmacology , v. 171, p. 113679, 2020.

 

Doi: 10.1016/j.bcp.2019.113679

Costa, G. ; Montagnoli, T. L. ; Da SILVA, J. S. ; Alencar, A. K. N. ; Gamba, L. E.R. ; Alves, B. E.O. ; Moraes, M. C. ; Trachez, M. M ; Nascimento, J. H.M. ; Coelho, P.M.P. ; Mendez-otero, R. ; Lima, L.M. ; Barreiro, E.J. ; Sudo, Roberto Takashi ;  Sudo, G.Z . New benzofuran N-acylhydrazone reduces cardiovascular dysfunction in obese rats by blocking TNF-alpha synthesis. Drug Design Development and Therapy , v. 14, p. 3337-3350, 2020.

 

Doi: 10.2147/DDDT.S258459

Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Selmi-ruby, S. ; Maximo, V. ; Soares, P. ;  Alves, L. M. Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and Cellular Endocrinology , v. 502, 2020.

 

Doi: 10.1016/j.mce.2019.110677

 

3.

Reis, E.M. ; Nobre, C. C. G. ; Chagas, A.P. ;  Alves, L.M. ; Junior, C.B . Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2020.

 

Doi: 10.23937/2469-5696/1410048

Lindoso, RS ; Lopes, J.A. ; Binato, R. ; Abdelhay, E. ; Takiya, C.M. ; Miranda, K.R. ; Lara, L. S. ; Viola ,A ; Bussolati, B ; Vieyra, A. ; Collino F . Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection. Molecular Therapy-Methods & Clinical Development, v. 16, p. 63-77, 2020.

Doi:10.1016/j.omtm.2019.11.002

Dick, C. F. ; Guimarães, L.M. ; Kelly, L.F.C. ; Cortes, A.L. ;  Morcillo, L.L.S. ; Sampaio, L.S. ; Fernandes, J. R.M. ; Vieyra, A. . A ferric reductase of Trypanosoma cruzi (TcFR) is involved in iron metabolism in the parasite. Experimental Parasitology, v. 217, p. 107962, 2020.

Doi:10.1016/j.exppara.2020.107962

 

Lima, J. A. ; R. Costa, T.W. ; Fonseca, A. C.C. ; Amaral, R. F. ; Nascimento, M.D. S.B. ; Filho, O.A.S. ; Miranda, A.L.P. ; Neto, D.C.F.; Lima, F.R.S. ; Hamerski, L. ; Tinoco, L. W.  Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorganic chemistry, v. 104, p. 104215, 2020.

Nunes, I.C.N. ; Souza, E.T. ; Martins, I.R.M. ; Barbosa, G. ; Junior, M.O.N. ; Medeiros, M.M. ; Silva, S. W.D. ; Balliano, T.L.; Silva, B.A. ; Silva, P.M.R.; Carvalho, V.F. ; Martins, M.A.; Lima, L.M.  Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 204, p. 112492, 2020.

DOI: 10.1016/j.ejmech.2020.112492

Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S.; Silva, E.T.; Souza, M.V.N. ; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A . Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology , v. 11, p. 1159, 2020.

Doi.: 10.3389/fphar.2020.01159

Pinto, D.P. ; Coutinho, D.S. ; Carvalho, K.I.M. ; Ferrero, M. R. ; Silva, L.V. ; Silveira, G.P. E. ; Silva, D. M.; Araújo, J.F.G. ; Silva, A. C.A. ; Pereira, H.M. ; Fonseca, L.B. ; Faria, R.X. ; Souza, M.V.N. ; Silva, E.T.; Filho, O.A.S. ; Costa, J.C. ; Amendoeira, F. C. ; Martins, M.A. Pharmacological profiling of JME-173, a novel mexiletine derivative combining dual anti-inflammatory/anti-spasmodic functions and limited action in Na+ channels. European Journal of Pharmacology. v. 885, p. 173367, 2020.

Doi:10.1016/j.ejphar.2020.173367

 

Aguiar, R.P.S. ; Peruchetti, D.B. ; Rocco, P.R.M. ; Schmaier, A.H. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, Vinicius de Frias ; Pinheiro, A.A.S. ; Neves, C.C . Role of the renin angiotensin system in the development of severe COVID-19 in hypertensive patients. AJP: Lung Cellular and Molecular Physiology, v. 000, p. 000, 2020.

Doi:10.1152/ajplung.00286.2020

Mattos, M. S. ; Ferrero, M. R. ; Kraemer, L. ; Lopes, G. A. ; Reis, D. C. ; Oliveira, F. M. ; Cassali, G. D. ; Brandolini, L. ; Allegretti, M. ; Garcia, C. C. ; Martins, M.A. ; Teixeira, M. M. ; Russo, R. C. CXCR1 and CXCR2 inhibition by Ladarixin improves neutrophil-dependent airway inflammation in mice. Frontiers in Immunology , v. 00, p. 000, 2020.

Silva, M.F. ; Lima, E.T. ; Pruccoli, Letizia ; Castro, N. ; Guimarães, M. ; Silva, F. ; Nadur, N.F. ; Azevedo, L. ; Kümmerle, A. ; Guedes, I.; Dardenne, L. ; Gontijo, V. ; Tarozzi, A. ; Viegas, C. Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer?s Disease. Molecules, v. 25, p. 3165, 2020.

 

Doi: 10.3390/molecules25143165

Prado, V.M. ; Queiroz, T.B.; Sá, P. M. ; Seiceira, R.C. ; Boechat, N. ; Ferreira, F.F . Mechanochemistry for the production of a hybrid salt used in the treatment of malaria. Green Chemistry, v. 22, p. 51-61, 2020.

 

Doi:10.1039/C9GC02478F

 

Rogerio, K.R. ; Graebin, C.S. ; Domingues, L.H.P. ; Oliveira, L.S. ; Silva, V.S.F.; Ribeiro, C.T.D. ; Carvalho, L. J.M. ; Boechat, N. Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum. Current topics in Medicinal Chemistry, v. 20, p. 99-110, 2020.

 

Doi: 10.2174/1568026619666191019100711

Nunes, I. K. C. ; Souza, E. T. ; Martins, I. R. R. ; Barbosa, G. ; Junior, M. O.M ; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, C. ; Martins, M. A. ; LM, Lima . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.

 

Doi: 10.1016/j.ejmech.2020.112492

Silva, N. L. C. ; Mota, N A V ; Soares, M. A. ; Araujo OMO ; Espindola, L C P ; Colombo, A P V ; Lopes, R T ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.

Doi: 10.1111/jre.12730

 

 

Gomes, A. C. C. ; Soares, Mariana, A. ; Gomes, A. K. C. ; Silva, Natália, L. C. ; Miranda, A. L. P. ; Tributino, J. L. M. ; LUZ, D. A. ; Amorim, GISELE C. ; Simas, N. K. ; KUSTER, R. M.  Antinociceptive constituents from Saccharum officinarum L. juice. Natural product research, v. 34, p. 1-5, 2020.

 

Doi: 10.1080/14786419.2020.1771708

Rodrigues, D.A. ; Guerra, F.S. ; Sagrillo, F.S.. ; Pinheiro, P.S.M. ; Alves, M.A. ; Thota, S. ; Chaves, L.S. ; Santanna, C.M.R. ; Fernandes, P.D. ; Fraga, C.A.M . Design, Synthesis and Pharmacological Evaluation of  First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors. ChemMedChem, v. 15, p. 539-551, 2020.

Doi: 10.1002/cmdc.201900716

 

Fokoue, H. ; Pinheiro, P. ; Fraga, C. ; Santanna, C. Há algo novo no reconhecimento molecular aplicado à química medicinal?. Quimica nova, v. 43, p. 78-89, 2020.

Doi: 10.21577/0100-4042.20170474 

 

Freitas, R.H.C.N. ; Barbosa, J.M.C. ; Bernardino, P. ; Sueth-santiago, V. ; Wardell, S.M.S.V. ; Wardell, J. L. ; Ricardo, D. D.; Melo,T.G. ; Silva,E.F. ; Salomão, K. ; Fraga, C.A.M . Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives. Biomedicine & pharmacotherapy, v. 127, p. 110162, 2020.

Doi: 10.1016/j.biopha.2020.110162

 

 

Neves, B.J. ; Agnes, J.P. ; Gomes, M.N. ; Donza, M.R.H. ; Gonçalves, R.M. ; Delgobo, M. ; Neto, lauro ; Senger, M.R. R.S. ;  Junior, F.P.S. ; Ferreira, S.B. ; Filho, A.Z. ; Andrade, C.H . Efficient identification of novel anti-glioma lead compounds by machine learning models. european journal of medicinal chemistry, v. 189, p. 111981, 2020.

Doi: 10.1016/j.ejmech.2019.111981


Neto, L.R.S. ; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in chemistry, v. 8, p. 1-18, 2020.

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Doi: 10.3389/fchem.2020.00093

 

Silva, V.D. ; Silva, R.R. ; Neto, J.G. ; Corcuera, B.L. ; Guimaraes, M.Z. ; Noël, F. ; Antonio, C.B.  New α-hydroxy-1,2,3-triazoles and 9h-fluorenes-1,2,3-triazoles: synthesis and evaluation as glycine transporter 1 inhibitors. Journal of the brazilian chemical society, v. 31, p. 1258-1269, 2020.

Doi: 10.21577/0103-5053.20200011 


Noël, F.; Lima, J.  Pharmacological aspects and clues for the rationale use of Chloroquine/Hydroxychloroquine facing the therapeutic challenges of COVID-19 pandemic. Latin American Journal of Clinical Sciences and Medical Technology, v. 2, p. 28-34, 2020.


Bray, M. ; Rayner, C. ; Noël, F. ; Jans, D. ; Wagstaff, K.  Ivermectin and COVID-19: a report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. ANTIVIRAL RESEARCH, v. 1, p. 104805, 2020.

Doi: 10.1016/j.antiviral.2020.104805


Noël, F. Suggesting Treatments for COVID-19. Beware! Expectations cannot Replace Good Science. Latin American Journal of Clinical Sciences and Medical Technology, v. 2, p. 43-43, 2020.

Doi: 10.26633/RPSP.2020.40

 

Marques, A. M. ; Macena, M. V. ; Cardoso, A. R. ; Hammes, C. S. O. ; Pinheiro, F.M.L. ; Castro, N. G. ; Neves, G.A.  Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice. Psychopharmacology, v. (), p. 1-13, 2020.

Doi: 10.1007/s00213-020-05485-0

 

Rodrigues, D.A. ; Pinheiro, P.S.M. ; Sagrillo, F.S.; Freitas, M.C.R. ; Alves, M.A. ; Thota, S. ; Tinoco, L.; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety. New journal of chemistry, v. 44, p. 10994-11005, 2020.

Doi:10.1039/D0NJ01598A

 

 

Thompson'souza, G.A. ; Santos, G.M.P. ; Silva, J.C. ; Muniz, V.S. ; Braga, Y.A.V. ; Figueiredo, R.T. ; Melo, R.C.N. ; Santos, A.L.S. ; Pinto, M.R. ; Neves, J.S.  Histoplasma capsulatum -induced extracellular dna trap release in human neutrophils. cellular microbiology, v. x, p. x, 2020.

Doi: 10.1111/cmi.13195

 

Sisnande, T. ; Lima, C.K. ; Silva, D.C. ; Moulin ,T.B.. ; Leao, N. ; Amaral, M.J. ;  Alves, L.M. ; Lima, L.M.T.R. Dietary zinc restriction promotes degeneration of the endocrine pancreas in mice. Biochimica et biophysica acta-molecular basis of disease, v. 1866, p. 165675, 2020.

Doi: 10.1016/j.bbadis.2020.165675


Reis, E.M. ; Nobre, C.C.G. ; Chagas, A.P. ;  Alves, L.M. ; Junior, C.B . Effects of tsh in erythrocyte osmotic fragility: signalling pathway. International journal of blood research and disorders, v. 7, p. 1-7, 2020.

Doi: 10.23937/2469-5696/1410048

 

Podratz, P.L. ; Merlo, E. ; Araujo, J.F.P. ; Ayub, J.G.M. ; Pereira, A.F.Z. ; Lima, L.C.F. ; Costa, M.B.C. ;  Alves, L.M. ; Cassa, S.G.S.C. ; Carneiro, M.T.W.D. ; Fillmann, G. ; Graceli, J.B . Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats. Science of the total environment, v. 723, p. 138000-xxx, 2020.

Doi: 10.1016/j.scitotenv.2020.138000


Alves, Marina A. ; Queiroz, A.C. ; Leite, A.B. ; Martins, F.T. ; Doriguetto, A.C. ; Barreiro, E. J. ; Moreira, M.S.A. ; Lima, L.M. . Carbamoyl- N -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.

 

Casanova,L.M. ; Rodrigues, L.M. ; Aguiar, P.F. ; Tinoco, L.W . An NMR-Based Chemometric Strategy to Identify Leishmania donovani Nucleoside Hydrolase Inhibitors from the Brazilian Tree Ormosia arborea. Journal of natural products, v. 83, p. 243-254, 2020.

 

Doi: 10.1021/acs.jnatprod.9b00622

Calassara, L.L. ; Pinto, S.C.; Condack, C.P.M. ; Leite, B.F. ; Nery, L.C.E.S. ; Tinoco, L.W.; Aguiar, F.A. ; Leal, I.C.R. ; Martins, S.M. ; Silva, L.L. ; Raimundo, J.M.; Muzitano, M.F . Isolation and characterization of flavonoids from tapirira guianensis leaves with vasodilatory and myeloperoxidase-inhibitory activities. Natural product research, v. 000, p. 1-4, 2020.

Doi: 10.1080/14786419.2020.1784170

 

Lourenço, E.M.G. ; Fernandes, J.M. ; Carvalho, V.F. ; Grougnet,R. ; Martins, M.A. ; Jordão, A.K. ; Zucolotto, S.M. ; Barbosa, euzébio g.  Identification of a selective pde4b inhibitor from bryophyllum pinnatum by target fishing study and in vitro evaluation of quercetin 3-o-α-l-arabinopyranosyl-(1→2)-o-α-l-rhamnopyranoside. Frontiers in pharmacology, v. 10, p. 1-12, 2020.

Doi: 10.3389/fphar.2019.01582

 

Ferreira, T.P.T. ; Lima, J.G.M. ; Filho, F.A.F. ; Sá, Y.A.P.J. ; Arantes, A.C.S. ; Guimarães, F.V. ; Carvalho, V.       F. ; Hogaboam, C. ; Wallace, J. ; Martins, M.A. ; Silva, P.M.R . Intranasal flunisolide suppresses pathological alterations caused by silica particles in the lungs of mice. Frontiers in endocrinology, v. 11, p. xx, 2020.

Doi: 10.3389/fendo.2020.00388


 

Ventura,R.D. ; Chaves, A.S. ; Magalhaes, N.S. ; Gonzalez, F.B. ; Pacini, M.F. ; Perez, A.R. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, V.F . Activation of pparγ reduces n-acetyl-cysteine -induced hypercorticoidism by down-regulating mc2r expression into adrenal glands. Free radical biology and medicine, v. xx, p. xx, 2020

 

Doi: 10.1016/j.freeradbiomed.2020.06.008

 

Marques, A.M. ; Macena, M.V. ; Cardoso, A.R. ; Hammes, C.S.O. ; Pinheiro, F.M.L. ; Castro, N. G. ; Neves, G. A.  Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice. Psychopharmacology, v. 00, p. 1-13, 2020.

DOI: 10.1007/s00213-020-05485-0

 

 

Pimentel, L.C.F.; Cunha, A.C. ; Hoelz, L.C.B. ; Canzian, H.F. ; Marinho, D.I.L.F. ; Boechat,N. ; Bastos, M.M. Phenylamino-pyrimidine (pap) privileged structure: synthesis and medicinal applications. Current topics in medicinal chemistry, v. 20, p. 227-243, 2020.

 

Doi: 10.2174/1568026620666200124094949

 

Cordeiro, N.M. ; Freitas, R.H.C.N. ; Fraga, C.A.M. ; Fernandes, P.D . New 2-amino-pyridinyl-n-acylhydrazones: synthesis and identification of their mechanism of anti-inflammatory action. Biomedicine & pharmacotherapy, v. 123, p. 109739, 2020.

Doi: 10.1016/j.biopha.2019.109739

Cordeiro, M.S. ; Simas, D.L.R. ; Sabino, J.F.P. ; Reyes, M.S.M. ; Muñoz-wug, M.A. ; Oliva-hernández, Bessie, E. ; S.;Antônio ,J.R. ; Fernandes, P.D. ; Giorno, T.B.S . Characterization of the antinociceptive activity from stevia serrata cav. Biomedicines, v. 8, p. 79, 2020.

Doi: 10.3390/biomedicines8040079

 

Salomé, DC ; Cordeiro, N.M. ; Valerio, T.S. ; Santos, D.A. ; Alves, P.B. ; Alviano, C.S. ; Alviano, D.S. ; Fernandes, PD . Aristolochia trilobata: Identification of the Anti- Inflammatory and Antinociceptive Effects. Biomedicines, v. 8, p. 111-129, 2020.

Doi: 10.3390/biomedicines8050111

 

Sakipova, Z. ; Giorno, T.B.S. ; Bekezhanova, T. ; Wong, N.S.H. ; Shukirbekova, A. ; Fernandes, P.D. ; Boylan, F . Pharmacological Evaluation of Artemisia cina Crude CO2 Subcritical Extract after the Removal of Santonin by Means of High Speed Countercurrent Chromatography. Molecules, v. 25, p. 2728, 2020.

Doi: 10.3390/molecules25122728

 

Cordeiro, N.M. ; Freitas, R.H.C.N. ; Fraga, C.A.M. ; Fernandes, P.D . Therapeutic effects of anti-inflammatory n-acylhydrazones in the resolution of experimental colitis. Journal of pharmacology and experimental therapeutics, v. 374, p. jpet-ar-2020-000074, 2020.

Doi:10.1124/jpet.120.000074

 

Tavares, L. P. ; Negreiros-lima, G. ; Lima, K. M. ; E Silva PM ; Pinho, V. ; Teixeira, M. M. ; Souza LP . Blame the signaling: role of cAMP for the resolution of inflammation. Pharmacological research, v. x, p. xx, 2020.

Doi: 10.1016/j.phrs.2020.105030

 

Souza, B.R. ; Saguie , B.O.; Nogueira , N.P.A.; Paes , M. ; Valença, S.S. ; Atella , G.C. ; Costa, A.M.A.  Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-κB and NRF2 pathways. Food research international, v. 131, p. 108984, 2020.

Doi: 10.1016/j.foodres.2020.108984

 

Alves, D.R.F. ; Pinto, J.B. ; Rodrigues, F.R. ; Valverde, P. ; Fernandes, D.C.S. ; Accioly, M. ;  Valenca, S.S. ; Perini, J.A. ; Jorge, R.V . Cox-2 expression in breast cancer and impact on survival outcomes. Journal of cancer science and clinical therapeutics, v. 04, p. 120-132, 2020.

 

Cattani-cavalieri, I. ; Valença, S.S. ; Schmidt, M . Nanodomains in cardiopulmonary disorders and the impact of air pollution. Biochemical society transactions, v. 05, p. 50, 2020.

Doi: 10.1042/BST20190250

Cordeiro, N.M. ; Freitas,R.H.C.N. ; Fraga, C.A.M ; Fernandes, P.D . New 2-amino-pyridinyl-n-acylhydrazones: synthesis and identification of their mechanism of anti-inflammatory action. Biomedicine & pharmacotherapy, v. 123, p. 109739, 2020.

 

Doi: 10.1016/j.biopha.2019.109739      

 

Montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; JunioR, F.P.S. Schistosoma mansoni cathepsin d1: biochemical and biophysical characterization of the recombinant enzyme expressed in hek293t cells. Protein expression and purification , v. 167, p. 105532, 2020.

 

Doi: 10.1016/j.pep.2019.105532

Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F.G. . Conformational states of the pig kidney na+/k+-atpase differently affect bufadienolides and cardenolides: a directed structure-activity and structure-kinetics study. Biochemical pharmacology , v. 171, p. 113679, 2020.

 

Doi:10.1016/j.bcp.2019.113679

Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Ruby, S.S. ; Maximo, V. ; Soares, P. ; Alves, L.M . Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and cellular endocrinology , v. 502, p. 110677. 2020.

Prado,V.M.; Queiroz,T.B.; Sá,P.M. ; Seiceira, R.C.; Boechat, N. ; Ferreira,F.F. Mechanochemistry for the production of a hybrid salt used in the treatment of malaria. Green chemistry , v. 22, p. 51-61, 2020.

Doi:10.1039/c9gc02478f

Rogerio,K.R. ; Graebin, C. S. ; Domingues, L. H. P. ; Oliveira, L. S. ; Silva, V. S. F. ; Ribeiro, D.C. T. ; Carvalho, L. J. M. ; Boechat, N.  Novel quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives against chloroquine-resistant plasmodium falciparum. Current topics in medicinal chemistry , v. 20, p. 99-110, 2020.

Doi: 10.2174/1568026619666191019100711

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Dias A. F. ; Lara, L. S. ; Filho , H.M. ; Vieyra, A.  Is angiotensin-(3-4) (val-tyr), the shortest angiotensin ii derived peptide, opening new vistas on renin angiotensin system?. Jraas. Journal of the renin-angiotensin-aldosterone system , v. 18, p. 147032031668933, 2017.

 

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Guerra, F.S.; Oliveira, R.G.; Fraga, C.A.M.; Mermelstein, C.S.; Fernandes, P.D . Rock inhibition with fasudil induces beta-catenin nuclear translocation and inhibits cell migration of mda-mb 231 human breast cancer cells. Scientific reports , v. 7, p. 13723, 2017.

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Silva, E.R. ; Oliveira, D.R. ; Fernandes, P.D. ; Bizzo, H.R. ; Leitão, S.G . Ethnopharmacological evaluation of breu essential oils from protium species administered by inhalation. Evidence-based complementary and alternative medicine , v. 2017, p. 1-10, 2017.

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Oliveira, L. G. ; Testasicca, M. C.S. ; Vargo , J.P.; Figueiredo, A. B. ; Canavaci, A. ; perucci, L. O. ; Ferreira, T. P. T. ; Coelho, E. A. F. ; Goncalves, D. U. ; Rocha, M. O. C. ; Silva , P;M.; Ferreira, C. N. ; Junior, C.Q. ; Souza, L.P.; Fernandes, A. P. Annexin a1 is involved in the resolution of inflammatory responses during leishmania braziliensis infection. Journal of immunology, v. 198, p. 3227-3236, 2017.

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Ribeiro, E.L. ; Fragoso, I.T. ; Gomes, F.O.S. ; Oliveira, A.C. ; Silva, A.K.S.  ; Silva, P.M.; Ciambarella, B.T. ; Ramos, I.P.R. ; Peixoto, C.A . Diethylcarbamazine: a potential treatment drug for pulmonary hypertension?. Toxicology and applied pharmacology, v. 333, p. 92-99, 2017.

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Costa, P.R.R. Interaction between bioactive compound 11a-n-tosyl-5-deoxi-pterocarpan (lqb-223) and calf thymus dna: spectroscopic approach, electrophoresis and theoretical studies. International journal of biological macromolecules, alemanha, v. 96, p. 223-233, 2017.

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Costa, P.R.R.; Cívicos, J. ; Coimbra, J. Solvent-free synthesis of salen ligands and pd(ii)- and cu(ii)-salen complexes: their use in the oxidation of α-tetralones to α-naphthols. Synthesis-stuttgart, v. 49, p. A-1, 2017.

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Cívicos, J. ; Costa, P.R.R. ; Domingos, J. Palladium-catalyzed α-arylation of dimethyl malonate and ethyl cyanoacetate with o-alkoxybromobenzenes for the synthesis of phenylacetic acid, esters and phenylacetonitriles. Synopen, v. 01, p. 0091-0096, 2017.

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Ribeiro,V.P. ; Melo, A.C.; Feitosa, E.K. ; Reis, A.G. ; Barroso, M.V. ; Cavalieri, I.C. ; Carvalho, G.M.C. ; Zin, W.A. ; Porto, L.C. ; Gitirana, L.B. ; Lanzetti, M. ; Valença, S.S. Atorvastatin and simvastatin promoted mouse lung repair after cigarette smoke-induced emphysema. Inflammation, v. 40, p. 965-979, 2017.

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Nesi, R.T. ; Feitosa, E.K.; Lanzetti, M. ; Ávila, M.B.; Magalhães, C.B. ; Zin, W.A. ; Faffe, D.S. ; Porto,L.C. ; Valença, S.S . Inflammatory and oxidative stress markers in experimental allergic asthma. Inflammation, v. 40, p. 1166-1176, 2017.

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Nesi, R.T. ; Barroso, M.V. ; Muniz, V.S. ; Arantes, A.C.; Martins, M.A. ; Gitirana, Lycia ; Neves, J.S. ; Benjamim, C.F. ; Lanzetti, M. ; Valença, S.S . Pharmacological modulation of reactive oxygen species (ros) improves the airway hyperresponsiveness by shifting the th1 response in allergic inflammation induced by ovalbumin. Free radical research, v. 51, p. 708-722, 2017.

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Silva,E.R. ; Boechat, N.; Pinheiro, L.C. S. ; Bastos, M.M. ; Costa, C.C. P. ; Bartholomeu, J.C.; Costa, T.H.  Novel selective inhibitor of leishmania (leishmania) amazonensis arginase. Chemical biology & drug design (print), v. 86, 2015.

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Boechat, N.; Carvalho, A.S. ; Salomão, K. ; Castro, S.L. ; Lima, C.F. ; Mello, F.V.C. ; Felzenszwalb, I. ; Aiub, C.A.F. ; Conde, T.R. ; Zamith, H.P.S. ; Skupin,R. ; Haufe, G . Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group. Memórias do instituto oswaldo cruz, v. 110, p. 492-499, 2015.

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Pinheiro, M.M.G. ; Miltojevi', A.B. ; Radulovi', N.S. ; Wahab, I.R.A.; Boylan, F. ; Fernandes, P.D.  Anti-inflammatory activity of choisya ternata kunth essential oil, ternanthranin, and its two synthetic analogs (methyl and propyl n-methylanthranilates). Plos one , v. 10, p. E0121063, 2015.

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Vieira, A.G. ; Marinho, B.G. ; Souza, L.G. ; Fernandes, P.D. ; Villar,J.D.F.  Design, synthesis and in vivo evaluation of sodium 2-benzyl-chloromalonates as new central nervous system depressants. Medchemcomm , p. 1427-1437, 2015.

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Giorno,T.B.S.; Ballard, Y.L.L. ; Cordeiro, M.S. ; Silva, B.V. ; Pinto, A.C. ; Fernandes, P.D . Central and peripheral antinociceptive activity of 3-(2-oxopropyl)-3-hydroxy-2-oxindoles. Pharmacology, biochemistry and behavior , v. 135, p. 13-19, 2015.

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Guilhon, C.C. ; Wahab, I.R.A. ; Boylan, F. ; Fernandes, P.D. Central antinociceptive and mechanism of action of kunth leaves crude extract, fractions, and isolated compounds. Evidence-based complementary and alternative medicine (print) , v. 2015, p. 1-12, 2015.

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Campos, V.R.; Cunha, A.C. ; Silva, W.A. ; Ferreira, V.F. ; Sousa, C.S. ; Fernandes, P.D. ; Moreira, V.N. ; Rocha, D.R. ; Dias,F.F.R. ; Montenegro, R.C. ; Souza, M.C.B.V. ; Boechat,F.C.S. ; Franco, C.F.J. ; Resende, J.A.L.C . Synthesis of a new class of naphthoquinone glycoconjugates and evaluation of their potential as antitumoral agents. Rsc advances: an international journal to further the chemical sciences , v. 5, p. 96222-96229, 2015.

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Silva, J.H. ; Borges, V.R.A. ; Pereira, L.C.B. ; Ferrari, R. ; Mattos, R.M. ; Barros, E.G.O.; Palmero, C.Y. ; Fernandes, P.D. ; Carvalho, P.R. ; Sousa, V.P. ; Cabral, L.M. ; Nasciutti, L.E.   The oil-resin of the tropical rainforest tree c opaifera langsdorffii reduces cell viability, changes cell morphology and induces cell death in human endometriotic stromal cultures. Journal of pharmacy and pharmacology , v. 26, 2015.

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Machado, M.M. ; Tomaz, M.A. ; Fonseca, R.J.C. ; Strauch,M.A. ; Cons, B.L. ; Borges, P.A.; -Neto, F.C.P. ; Henriques, M.S.T. ; Cruz, J.M.T. ; Elias, S.C. ; Cintra, A.C.O. ; Martinez, A.M.B. ; Mourão, P.A.S. ; Melo, P.A.  Occurrence of sulfated fucose branches in fucosylated chondroitin sulfate are essential for the polysaccharide effect preventing muscle damage induced by toxins and crude venom from bothrops jararacussu snake. Toxicon (oxford) , v. 98, p. 20-33, 2015.

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Ribeiro, M.F. ; Oliveira, F.L. ; Machado, M.M. ; Cardoso,P.F.; Ferraz, V.V.C.G. ; Melo, P.A. ; Souza, C.M.V.; Elias, S.C.  Pattern of inflammatory response to loxosceles intermedia venom in distinct mouse strains: a key element to understand skin lesions and dermonecrosis by poisoning. Toxicon (oxford) , v. 96, p. 10-23, 2015.

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Guimarães, M. A. ; Ramundo, M. S. ; Américo, M. A. ; Mattos, M. C. ; Souza, R. R. ; Júnior, E. S.R. ; Coelho, L. R. ; Morrot, A. ; Melo, P. A. ; Fracalanzza, S. E. L. ; Ferreira, F. A. ; Figueiredo, A. M. S.  A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant staphylococcus aureus related to the usa400 clone. European journal of clinical microbiology & infectious diseases (print) , v. 34, p. 497-509, 2015.

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Muniz, V.S. ; Reis,R.B. ; Benjamim, C.F. ; Santos, H.A.M. ; Pyrrho, A.S. ; Strauch, M.A.  ; Melo, P.A. ; Vicentino, A.R. R. ; Paiva, J.S. ; Melo, C.B. ; Weller, P.F. ; Figueiredo, R.T.; Neves, J.S . Purinergic p2y12 receptor activation in eosinophils and the schistosomal host response. Plos one , v. 10, p. E0139805-21, 2015.

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Insuela, D.B.R.; Daleprane, J. B. ; Coelho , L.P. ; Silva, A. R. ; Silva , P.M.; Martins, M.A. ; Carvalho, V.F.  Glucagon induces airway smooth muscle relaxation by nitirc oxide and prostaglandin e2. Journal of endocrinology, v. 225, p. 1-14, 2015.

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Vago, J. P. ; Tavares, L. P. ; Garcia, C. C. ; Lima, K. M. ; Perucci, L. O. ; Vieira, E. L. ; Nogueira, C. R. C. ; Soriani, F. M. ; Martins, J. O. ; Silva , P.M.; Gomes, K. B. ; Pinho, V. ; Bruscoli, S. ; Riccardi, C. ; Beaulieu, E. ; Morand, E. F. ; Teixeira, M. M. ; Sousa, L. P.  The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution. The journal of immunology (1950), v. 194,  2015.

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Manvar, D. ; Fernandes, T.A. ; Domingos, J.L.O. ; Baljinnyam, E. ; Basu, A. ; Junior, E.F.T.; Costa, P.R.R. ; Basu, N.K . Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis c virus inhibitors. European journal of medicinal chemistry, v. 93, p. 51-54, 2015.

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Faria, F. ; Leal, M.B. ; Bernardo,P. ; Costa, P.R.R. ; Maia, R . Nfκb pathway and microrna-9 and -21 are involved in sensitivity to the pterocarpanquinone lqb-118 in different cml cell lines. Anti-cancer agents in medicinal chemistry, v. 15, p. 345-352, 2015.


Buarque, C. ; Domingos,J. ; Netto, C. ; Costa, P.R.R. Palladium-catalyzed oxyarylation, azaarylation and α-arylation reactions in the synthesis of bioactive isoflavonoid analogues. Current organic synthesis, v. 12, p. 772-794, 2015.

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Silva, K.L. ; Souza, P.S. ; Costa, P.R.R. ; Maia, R.C . Abstract a51: antineoplastic activity of novel synthetic compound pterocarpanquinone lqb-118 in lung cancer cells. Clinical cancer research (print), v. 21, p. A51-a51, 2015.

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Reis, F.R.S. ; Mororó, J.S. ; Silva, K.L. ; Buarque, C.D. ; Costa, P.R.R. ; Maia, R.C . Abstract a49: efficiency of 11a-n-tosyl-5-deoxi-pterocarpan (lqb-223) in a panel of myeloid leukemia cell lines with different chemoresistance backgrounds. Clinical cancer research (print), v. 21, p. A49-a49, 2015.

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Costa, D.S.S. ; Martino, T. ; Magalhães, F.C. ; Justo, G. ; Coelho, M.G.P. ; Barcellos, J.C.F.; Moura, V.B. ; Costa, P.R.R. ; Sabino, K.C.C. ; Dias, A.G.  Synthesis of n-methylarylnitrones derived from alkyloxybenzaldehydes and antineoplastic effect on human cancer cell lines. Bioorganic & medicinal chemistry (print), v. 23, p. 2053-2061, 2015.

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Costa, P.R.R.; Sansano, J.M. ; Cossío,U. ; Barcellos, J.C. F. ; Dias, A.G. ; Nájera, C.; Arrieta, A. ; Cózar, A. ; Cossío, F.P . Synthesis of chromen[4,3- b ]pyrrolidines by intramolecular 1,3-dipolar cycloadditions of azomethine ylides: an experimental and computational assessment of the origin of stereocontrol. European journal of organic chemistry (print) , v. 2015, p. 4689-4698, 2015.

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Buarque, C.; Costa, P.R.R. ; Dias, A.; Barcellos, J. ; Borges,B. ; Mendes, J. ; Ceron, M . Synthesis of 11a-n-arylsulfonyl-5-carbapterocarpans (tetrahydro-5h-benzo[a]carbazoles) by azaarylation of dihydronaphthalenes with o-iodo-n-(arylsulfonyl)anilines in poly(ethylene glycol). Synthesis (stuttgart), v. 47, p. 3013-3019, 2015.

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Costa,P.R.R.; Moraes, P. ; Gaspar,F. ; Borges,R. ; Netto,C. ; Leão, R.; Nájera, C . Ligand-free palladium-catalyzed oxyarylation of dihydronaphthal­enes and chromenequinone with o-iodophenols and 3-iodolawsone in peg-400: an efficient synthesis of 5-carbapterocarpans and pterocarpanquinones. Synthesis (stuttgart), v. 47, p. 3505-3512, 2015.

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Silva, L.L.R. ; Portes, J.A. ; Araújo, M.H. ;  Silva, J.L.S. ; Rennó, M.N. ; Netto, C.D.;Silva, A.J.M. ; Costa, P.R.R. ; Souza, W. ; Seabra, S.H. ; Damatta, R.A . Further evidence that naphthoquinone inhibits toxoplasma gondii growth in vitro. Parasitology international (print), v. 64, p. 622-631, 2015.

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Lima, T.I. ; Monteiro, I.C. ; Valença, S.S. ; Cardoso, J.H.S. ; Fortunato, R.S. ; Carvalho, D.P. ; Teodoro, B.G. ; Ceccatto, V.M . Effect of exercise training on liver antioxidant enzymes in stz-diabetic rats. Life sciences (1973), v. 128, p. 64-71, 2015.

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Costa, M.R. ; Pires, K.M.P. ; Barbosa, M.N.N. ;  Valença, S.S.; Resende, A.C. ; Moura, R.S. Grape skin extract-derived polyphenols modify programming-induced renal endowment in prenatal protein-restricted male mouse offspring. European journal of nutrition (print), v. 55, p. 1455-1464, 2015.

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Sudo, G.Z.; Silva, J.S. ; Pereira, S.L. ; Souza, P.J.C. ; Moura, R.S. ; Sudo,R . Oral treatment with euterpe oleracea mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. Bmc complementary and alternative medicine (online) , v. 14, p. 227, 2014.

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Debom, R. ; trachez, M. M. ; Sudo  G.Z. ; Silva, J.S. ; Oliveira, K. M. ; Garcia, A. L. ; Godoy, L. M. ; Pacheco, P. C. ; Sudo, R.T . Novel nicotinic receptor agonist reduces hyperalgesia and allodynia of neuropathic pain in diabetic rats. Journal of diabetes & metabolism, v. 5, p. 396, 2014.

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Sudo, G.Z.Alencar, A.K.N.Sudo, R. T.  Targeting of the adenosine receptors as a novel strategy for the treatment of arterial hypertension. Journal of neurology and neurophysiology, v. 5, p. 243, 2014.

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Alencar, A.K.N,. ; Barreiro, E. J. ; Sudo, R. T. ; Sudo, G.Z . Adenosine a2a receptor as a target of treatment for pulmonary arterial hypertensio. Clinical research in pulmonology, v. 2, p. 1021, 2014.

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Fernandes, P.D. ; Guerra, F.S. ; Sales, N.M. ; Sardella, T.B. ; Jancar, S. ; Neves, J.S.  Characterization of the inflammatory response during ehrlich ascitic tumor development. Journal of pharmacological and toxicological methods , 2014.

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Barros, E.G.O. ; Palumbo, A. ; Mello, P.L.P. ; Mattos, R.M. ; Silva, J.H. ; Pontes, B. ; Viana, N.B. ; Amaral, R.F. ; Lima, F.R.S. ; Costa, N.M. ; Palmero, C.Y.; Alves, L.M. ; Takiya, C.M.  ; Nasciutti, L.E . The reciprocal interactions between astrocytes and prostate cancer cells represent an early event associated with brain metastasis. Clinical & experimental metastasis , v. 31, p. 461-474, 2014.

 

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Oliveira, K.J. ; Paula, G.S.M. ; Império, G.E. ; Bressane, N.O. ; Magalhães, C.M.A. ; Alves, L.M. ; Carvalho, T.M.O. ; Moura, C.C.P . Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin b receptor gene. Regulatory peptides (print) , v. 194, p. 30-35, 2014.

 

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Costa, F.N. ; Braz, D. ; Ferreira, F.F. ; Silva, T.F. ; Barreiro, E.J. ; Lima, L.M. ; Colaço, M.V. ; Kuplich, L. ; Barroso, R.C.  Synchrotron x-ray powder diffraction data of lassbio-1515: a new n-acylhydrazone derivative compound. Radiation physics and chemistry (1993) , v. 95, p. 292-295, 2014.

 

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Silva, Y. ; Reyes, C.; Rivera, G. ; Alves, M. ; Barreiro,E. ; Moreira, M. ; Lima, L.M . 3-aminothiophene-2-acylhydrazones: non-toxic, analgesic and anti-inflammatory lead-candidates. Molecules (basel. Online) , v. 19, p. 8456-8471, 2014.

 

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Lima, L.M. Novel partial agonist of ppar-gamma for treatment of diabetic neuropathy in rats. Journal of diabetes & metabolism, v. 05, p. 392-396, 2014.

 

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Sampaio, T.S. Synthesis, antiproliferative and anti-inflammatory activities of novel simplified imatinib analogues. Medicinal chemistry, v. 4, p. 756-762, 2014.

 

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Dias, J. ; Ferrao, F. M. ; Axelband, F. ; Carmona, A. K. ; Lara, L. S. ; Vieyra, A.  Ang-(3-4) inhibits renal na+-atpase in hypertensive rats through a mechanism that involves dissociation of ang ii receptors heterodimers and pka. American journal of physiology. Renal physiology , v. 306, p. F855-f863, 2014.

 

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Silva, P.A. ; Cahli, G.M. ; Acácio, A.P. ; Luzardo, R. ; Sampaio, L.S. ; Leite, M.A.L. ; Lara, L.S. ; Lamas, M.E. ; Panizzutti, R. ; Madeira, C. ; Filho,L.D. ; Chaves, C.C. ; Ribeiro, V.S. ; Paixão,A.D.O. ; Medei, E. ; Vieyra, A . Mechanisms involving ang ii and mapk/erk1/2 signaling pathways underlie cardiac and renal alterations during chronic undernutrition. Plos one , v. 9, p. E100410, 2014.

 

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Silva, P.A. ; Filho, H.M. ; Acácio, A.P. ; Dias, J. ; Martins, J.F.S. ; Vieira, M.L. ; Verdoorn, K.S. ; Lara, L.S. ; Filho, L.D.V. ; Cabral, E.V. ; Paixão, A.D.O. ; Vieyra, A . Altered signaling pathways linked to angiotensin ii underpin the upregulation of renal na+-atpase in chronically undernourished rats. Biochimica et biophysica acta. Molecular basis of disease , v. 1842, p. 1-10, 2014.

 

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Ferrão,F.M. ; Lara, L.S.  Renin-angiotensin system in the kidney: what is new?. World journal of nephrology, v. 6, p. 64-76, 2014.

 

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Filho, J.R. ; Leite,F.C.; Costa,H.F.; Calheiros,A.S.  ; Torres, R.C. ; Azevedo,C.T.; Martins,M.A.; Dias, C.S.; Bozza,P.T. ; Piuvezam, M.R.  Curine inhibits mast cell-dependent responses in mice. Journal of ethnopharmacology, v. 155, p. 1118-1124, 2014.

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Diniz, L.P. ; Tortelli, V. ; Garcia,M.N.; Araújo,A.P.B.; Melo,H.M. ; Silva,G.S.S.. ; Felice,F.G. ; Leon,S.V.A.; Souza, J. M. ; Romão,L.F.; Castro, N.G. ; Gomes, F.C.A.  Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via cam kinase ii signaling. Glia, v. 62, p. 1917-1931, 2014.

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Lacerda, R.B. ; Sales, N.M. ; Silva, L.l. ; Tesch, R ; Miranda, A.L. P; Barreiro, E.J. ; Fernandes, P.D. ; Fraga, C. A.M. Novel potent imidazo[1,2-a]pyridine-n-glycinyl-hydrazone inhibitors of tnf-α production: in vitro and in vivo studies. Plos one, v. 9, p. E91660, 2014.

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Lima, C. K. F ; Silva, R. M ; Lacerda R.B. ; Santos, B. L. R ; Silva, R. V. ; Amaral, l.S. ; Quintas, L. E. M. ; Fraga, C. A. M. ; Barreiro, E.J. ; Guimaraes, M.Z.P ; Miranda, A. L. P. Lassbio-1135: a dual trpv1 antagonist and anti-tnf-alpha compound orally effective in models of inflammatory and neuropathic pain. Plos one, v. 9, p. E99510, 2014.

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Pereira, S. L. ; Kummerle, A. E. ; Fraga, C.A.M. ; Barreiro, E. J. ; Sudo, R. T. ; Sudo,G.Z . Vasodilator and antihypertensive effects of a novel n-acylhydrazone derivative mediated by the inhibition of l-type ca2+ channels. Fundamental & clinical pharmacology , v. 28, p. 29-41, 2014.

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Silva, J.S.; Pereira, S.L. ; Maia, R.C. ; Landgraf, S.S. ; Neves, C.C. ; Kümmerle, A.E. ; Fraga, C.A.M. ; Barreiro, E.J. ; Sudo, R.T. ; Sudo, G.Z . N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life sciences (1973) , v. 94, p. 30-36, 2014.

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Alencar, A.K.N. ; Pereira, S. l. ; Silva, F.E. ; Mendes, L.V.P. ; Cunha, V.M.N. ; Lima, L.M. ; Montagnoli, T.I.. ; Neves, C.C. ; Ferraz, E.B. ; Resch, R. ; Nascimento, J.H.M. ; Sant’anna C.M.R.; Fraga, C.A.M. ; Barreiro, E.J. ; Sudo, R.T. ; Sudo, G.Z . N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertensionthrough the modulation of adenosine aa2r activity. International journal of cardiology (print) , v. 173, p. 154-162, 2014.

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Silva, R.B. ; Silva, E.F. ; Carvalho, S.A. ; Fraga, C.A.M; Wardell, S. M.S.V. ; Wardell,J. l. Crystal structures of 1-hydroxylimidazole and imidazole 1-oxide derivatives. Zeitschrift für kristallographie , v. 229, p. 709-722, 2014.

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Maia,R.C. ; Tesch, R ; Fraga, C.A.M . Acylhydrazone derivatives: a patent review. Expert opinion on therapeutic patents , v. 24, p. 1161-1170, 2014.

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Carvalho, S. ; Kaiser, M ; Brun, R. ; Silva, E. ; Fraga, C.A.M . Antiprotozoal activity of (e)-cinnamic n-acylhydrazone derivatives. Molecules (basel. Online) , v. 19, p. 20374-20381, 2014.

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Oliveira, S. D. S. ; Nanini, H. F. ; Baggio, l. E. S. ; Waghabi, M. C. ; Silva, C.L.M ; Silva, R.C . Macrophage p2x7 receptor function is reduced during schistosomiasis: putative role of tgf- 1. Mediators of inflammation , v. 2014, p. 1-12, 2014.

 

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Silva, F.C.; Viana, J.B.N. ; Romeiro, L.A.S. ; Barberato, L.C. ; Noël, F.G. ; Silva,C.L.M . Pharmacological characterization of n1-(2-methoxyphenyl)-n4-hexylpiperazine as a multi-target antagonist of α1a/α1d-adrenoceptors and 5-ht1a receptors that blocks prostate contraction and cell growth. Naunyn-schmiedeberg's archives of pharmacology , v. 387, p. 225-234, 2014.

 

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Barbosa, M.L.C. ; Lima, L.M. ; Tesch, R. ; Sant'anna, C.M.R. ; Totzke, F. ; Kubbutat,M.H.G. ; Schächtele, C. ; Laufer, S.A. ; Barreiro, E.J.  Novel 2-chloro-4-anilino-quinazoline derivatives as egfr and vegfr-2 dual inhibitors. European journal of medicinal chemistry , v. 71, p. 1-14, 2014.

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Nunes, I.C. ; Tinoco, L. ; Junior, H.M. ; Rezende, C. ; Barreiro,E.J. ; Lima, L.M . In vitro microsomal hepatic metabolism of antiasthmatic prototype lassbio-448. Current topics in medicinal chemistry (print) , v. 14, p. 1388-1398, 2014.

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Barreiro, E.J.Carvalho, G. M. C. ; Gomes, M. D. M. ; Oliveira, V. R. ; Casquilho, N. V. ; Araujo, A. P. ; Soares, R. M. ; Azevedo, S. O. ; Monteiro, A. P. T. ; Canetti, C. ; Lima, L. M. ; Zin, W. A.  Pulmonary and hepatic injuries caused by the subchronic exposure to microcystin-lr: role of the duration of treatment with lassbio 596. Seminars in respiratory and critical care medicine, v. 189, p. A5023-a5023, 2014.

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