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ARTIGOS EM PERIÓDICOS

2023

Aquino, Gabriel A. S.; Silva-Jr, Floriano P.; Ferreira, Sabrina B..  Ethyl Diazoacetate. SyOpen, v. 7, p. 110-113, 2023.

Doi: 10.1055/a-2038-6055

Araujo-Lima, Carlos F.; de Cassia, Carvalho, Rita de C. C.; Rosario, Sandra L.; Leite, Debora I.; Aguiar, Anna C. C.; Santos, Lizandra V. de S.; de Araujo, Julianna S.; Salomão, Kelly; Kaiser, Carlos R.; Krettli, Antoniana U.; Bastos, Monica M.; Aiub, Claudia A. F.; Soeiro, Maria de N. C.; Boechat, Nubia; Felzenszwalb, I.. Antiplasmodial, Trypanocidal, and Genotoxicity In Vitro Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives. Pharmaceutical, v. 16, p. 782, 2023.

Doi: 10.3390/ph16060782

Araujo-Lima, Carlos F.; Carvalho, Rita de C. C.; Peres, Raiza B.; Fiuza, Ludmila F. de A.; Galvão, Bárbara V. D.; Castelo-Branco, Frederico S.; Bastos, Mônica M.; Boechat, Nubia; Felzenszwalb, I.; Soeiro, Maria de N. C.. In silico and in vitro assessment of anti-Trypanosoma cruzi efficacy, genotoxicity and pharmacokinetics of pentasubstituted pyrrolic Atorvastatin-aminoquinoline hybrid compounds. Acta Trop., v. 242, p. 106924, 2023.

Doi: 10.1016/j.actatropica.2023.106924

Araujo-Lima, Carlos F.; Carvalho, Rita de C. C.; Rosario, Sandra L.; Leite, Debora I.; Aguiar, Anna C. C.; Santos, Lizandra V. de; Araujo, Julianna S. de; Salomão, Kelly; Kaiser, Carlos R.; Kretti, Antoniana U.; Bastos, Monica B.; Aiub, Claudia A. F.; Soeiro, Maria de N. C.; Boechat, Núbia; Felzenszwalb, I.. Antiplasmodial, Trypanocidal, and Genotoxicity In Vitro Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives. Pharmaceuticals, v. 16, n. 6, p. 782, 2023.

Doi: 10.3390/ph16060782 

Azeredo, Damáris B. C.; Anselmo, Denilson de S.; Soares, Paula; Graceli, Jones B.; Magliano, D'Angelo C.; Miranda-Alves, Leandro. Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic–Pituitary–Thyroid Axis. International Journal of Molecular Sciences, v. 24, n. 20, p. 15246, 2023.

Doi: 10.3390/ijms242015246 

Bezerra, Frank S.; Lanzetti, Manuela; Nesi, Renata T.; Nagato, Akinori C.; e Silva, Cynthia P.; Kennedy-Feitosa, Emanuel; Melo, Adriana C.; Cattani-Cavalieri, Isabella; Porto, Luís C.; Valença, Samuel S.. Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries. Antioxidants, v. 12, p. 548, 2023.

Doi: 10.3390/antiox12030548

Conceição, Raissa A. da; von Ranke, Natalia; Azevedo, Luciana; Franco, Daiana; Nadur, Nathalia F.; Kurmmerle, Arthur E.; Barbosa, Maria L. de C.; Souza, Alessandra M. T.. Structure‐based design of new N‐benzyl‐piperidine derivatives as multitarget‐directed AChE/BuChE inhibitors for Alzheimer's disease. Journal of Cellular Biochemistry, v. 124, p. 1734-1748, 2023.

Doi: doi.org/10.1002/jcb.30483

Conroy, Lindsey R.; Clarke, Harrison A.; Allison, Derek B.; Valença, Samuel S.; Sun, Qi; Hawkinson, Tara R.; Young, Lyndsay E. A.; Ferreira, Juanita E.; Hammonds, Autumn V.; Dunne, Jaclyn B.; McDonald, Robert J.; Absher, Kimberly J.; Dong, Brittany E.; Bruntz, Ronald C.; Markussen, Kia H.; Juras, Jelena A.; Alilain, Warren J.; Liu, Jinze; Gentry, Matthew S.; Angel, Peggi M.; Waters, Christopher M.; Sun, Ramon C.. Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis. Nature Communications, v. 14, n. 1, p. 2759, 2023.

Doi: //doi.org/10.1038/s41467-023-38437-1

Costa, Caroline M. X.; Aparecida-Silva, Cristiane; Gamba, Luis E. R.; de Melo, thalita N.; Barbosa, Gisele; Junior, Manoel O. M.; de Oliveira, Victoria R. T.; de Amorim, Carolinne S.; Moraes, João A.; Barreiro, Eliezer J.; Lima, Lídia M.. Design, Synthesis and Phenotypic Profiling of Simplified Gedatolisib Analogues. Pharmaceuticals, v. 16, p. 209, 2023.

Doi: 10.3390/ph16020209

Corrêa-Netto, Carlos; Strauch, Marcelo A.; Monteiro-Machado, Marcos; Teixeira-Araújo, Ricardo; Fonseca, Juliana G.; Leitão-Araújo, Moema; Machado-Alves, Maria L.; Sanz, Libia; Calvete, Juan J.; Melo, Paulo de A.; Zingali, Russolina B.. Monoclonal-Based Antivenomics Reveals Conserved Neutralizing Epitopes in Type I PLA2 Molecules from Coral Snakes. Toxins, v. 15, p. 15, 2023.

Doi: 10.3390/toxins15010015

Faria, Ana F. M.; Pereira, Caroline de S. F.; Teixeira, Guilherme P.; Galvão, Raíssa M. dos S.; Pacheco, Paulo A. F.; Bello, Murilo L. Jesus, Daiane H. de; Calabrese, Kátia; Gonzaga, Daniel T. G.; Boechat, Núbia; Faria, Robson X.. In vitro evaluation of 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole derivatives against replicative and infective stages of Trypanosoma cruzi. Journal of Bioenergetics and Biomembranes, p. 1-13, 2023.

Doi: //doi.org/10.1007/s10863-023-09982-7

Fujimaki, Carla M. de O.; de Lima, Cleverton K. F.; Miranda, Ana L. P.; Bernardo, Robson R.; Study of the presence of biphenyl polychlorates in the waters of the Bengalas River, Nova Friburgo, Rio de Janeiro. Journal of Engineering Research, v. 3, p. 2-7, 2023.

Doi: 10.22533/at.ed.317392328032

Gaspar, Tiago B.; Jesus, Tito T.; Azevedo, Maria T.; Macedo, Sofia; Soares, Mariana A.; Martins, Rui Sousa; Leite, Rúben; Rodrigues, Lia; Rodrigues, Daniela F.; Cardoso, Luís; Borges, Inês; Canberk, Sule; Gärtner, Fátima; Miranda-Alves, Leandro; Lopes, José M.; Soares, Paula; Vinagre, João. Generation of an Obese Diabetic Mouse Model upon Conditional Atrx Disruption. Cancers, v. 15, p. 318, 2023.

Doi: 10.3390/cancers15113018

Grahl, Matheus V. C.; Andrade, Brenda da S.; Perin, Ana P. A.; Neves, Gilda A.; Duarte, Laura de S.; Uberti, Augusto F.; Hohl, Kelvin S.; Follmer, Cristian; Carlini, Celia R.. Could the Urease of the Gut Bacterium Proteus mirabilis Play a Role in the Altered Gut–Brain Talk Associated with Parkinson’s Disease?. Microorganisms, v. 11, n. 8, p. 2042, 2023.

Doi: //doi.org/10.3390/microorganisms11082042

Gonçalves, Patricia F. R.; Nunes, Luis E. D.; Andrade, Brenda da S.; Silva, Mariana O. L. da; Souza, Isis N. de O.; Assunção-Miranda, Iranaia; Castro, Newton G.; Neves, Gilda A.. Age-dependent memory impairment induced by co-exposure to nicotine and a synthetic cannabinoid in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 127, p. 110821, 2023.

Doi: //doi.org/10.1016/j.pnpbp.2023.110821

Gonsalez, Sabrina R.; Gomes, Dayene S.; de Souza, Alessandro M.; Ferrão, Fernanda M.; Vallotton, Zoe; Gogulamudi, Venkateswara R.; Lowe, Jennifer; Casarini, Dulce E.; Prieto, Minofla C.; Lara, Lucienne S.. The Triad Na+ Activated Na+ Channel (Nax)-Salt Inducible KINASE (SIK) and (Na+ + K+)-ATPase: Targeting the Villains to Treat Salt Resistant and Sensitive Hypertension. Int. J. Mol. Sci., v. 24, p. 7887, 2023.

Doi: 10.3390/ijms24097887 

Gomes, Bárbara F.; Senger, Mario R.; Moreira-Filho, José T.; Junior, Fabio J. da V.; Dantas, Rafael F.; Owens, Raymond; Andrade, Carolina H.; Neves, Bruno J.; Silva-Júnior, Floriano P.. Discovery of new Schistosoma mansoni aspartyl protease inhibitors
by structure-based virtual screening
. Memórias do Instituto Oswaldo Cruz, v. 118, p. e230031, 2023.

Doi: //doi.org/10.1590/0074-02760230031

Guimarães, Daniel M.; Valério-Gomes, Bruna; Vianna-Barbosa, Rodrigo J.; Oliveira, Washington; Neves, Gilda A.; Tovar-Moll, Fernanda; Lent, Roberto. Social isolation leads to mild social recognition impairment and losses in brain cellularity. Brain Structure and Function, v. 228, n. 9, p. 2051-2066, 2023.

Doi://doi.org/10.1007/s00429-023-02705-z

Guimarães, Celina J.; Carneiro, Teiliane R.; Frederico, Marisa J. S.; de Carvalho, Guilherme G. C.; Little, Matthew; Freire, Valder N.; França, Victor L. B.; do Amaral, Daniel N.; Guedes, Jéssica S.; Barreiro, Eliezer J.; Lima, Lídia M.; Barros-Nepomuceno, Francisco W. A.; Pessoa, Cláudia. Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent. Pharmaceuticals, v. 15, p. 1282, 2023.

Doi: 10.3390/pharmaceutics15041282

Guilherme, Rafael F.; Silva, José B. N. F.; Waclawiak, Ingrid; Fraga-Júnior, Vanderlei S.; Nogueira, Thaís O.; Pecli, Cyntia; Araújo-Silva, Carlla A.; Magalhães, Nathália S.; Lemos, Felipe S.; Bulant, Carlos A.; Blanco, Pablo J.; Serra, Rafaela; Svensjö, Erik; Scharfstein, Júlio; Moraes, João A.; Canetti, Cláudio; Benjamim, Claudia F.. Pleiotropic antifibrotic actions of aspirin-triggered resolvin D1 in the lungs. Frontiers in Immunology, v. 14, p. 1, 2023.

Doi: 10.3389/fimmu.2023.886601

Insuela, Daniella B. R.; Ferrero, Maximiliano R.; Chaves, Amanda da S.; Coutinho, Diego de S.; Magalhães, Nathalia dos S.; Arantes, Ana C. S. de; Silva, Adriana R.; Silva, Patrícia M. R. e; Martins, Marco A.; Carvalho, Vinicius F.. Pro-resolving role of glucagon in lipopolysaccharide-induced mice lung neutrophilia. Journal of Endocrinology, v. 259, n. 1, 2023.

Doi: //doi.org/10.1530/JOE-22-0196

Kråkström, Matilda; Dickens, Alex M.; Alves, Marina A.; Forssten, Sofia D.; Ouwehand, Arthur C.; Hyötyläinen, Tuulia; Orešič, Matej; Lamichhane, Santosh. Dynamics of the Lipidome in a Colon Simulator. Metabolites, v. 13, p. 355, 2023.

Doi: 10.3390/metabo13030355 

Leite, Debora I.; Moura, Stefany de C. B.; Dias, Maria da C. A.; Costa, Carolina C. P.; Machado, Gustavo P.; Pimentel, Luiz C. F.; Castelo-Branco, Frederico S.; Moreira, Rui; Bastos, Mônica M.; Boechat, Nubia. A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens. Molecules, v. 28, p. 3342, 2023.

Doi: 10.3390/molecules28083342 

Leite, Debora I.; Campaniço, Andre; Costa, Pedro A. G.; Correa, Isadora A.; Costa, Luciana J. da; Bastos, Monica M.; Moreira, Rui; Lopes, Francisca; Jordaan, Audrey; Warner, Digby F.; Boechat, Núbia. New azaaurone derivatives as potential multitarget agents in HIV-TB coinfection. Archiv der Pharmazie, p. e2300560, 2023.

Doi: //doi.org/10.1002/ardp.202300560

Lima, Cleverton K. F.; Sisnande, Tháyna; Silva, Rafaela V. da; Silva, Vanessa D. C. S. da; Amaral, Julio J. do; Ochs, Soraya M.; Santos, Bruna L. R. dos; Miranda, Ana L. P. de; Lima, Luís M. T. R.. Zinc deficiency disrupts pain signaling promoting nociceptive but not inflammatory pain in mice. An Acad Bras Cienc, v. 95, p. e20220914, 2023.

Doi: 10.1590/0001-3765202320220914

Louback, Rafaela de A.; Martins-Cardoso, Karina; Tinoco, Luzineide T.; Collino, Federica; Barros, Ana P. D. N.; Fortuna-Costa, Annaliese; Monteiro, Robson Q.; Rossi, Maria I. D.; Lindoso, Rafael S.. Aspirin Affects MDA-MB-231 Vesicle Production and Their Capacity to Induce Fibroblasts towards a Pro-Invasive State. International Journal of Molecular Sciences, v. 24, n. 15, p. 12020, 2023.

Doi: 10.3390/ijms241512020 

 

Macedo, Sofia; Teixeira, Elisabete; Gaspar, Tiago B.; Boaventura, Paula; Soares, Mariana A.; Miranda-Alves, Leandro; Soares, Paula. Endocrine-disrupting chemicals and endocrine neoplasia: A forty-year systematic review. Environ Res., v. 218, p. 114869, 2023.

Doi: 10.1016/j.envres.2022.114869

Mafra, João C. M.; Boechat, Núbia; Teixeira, Guilherme P.; Faria, Robson X.. Synthetic molecules as P2X7 receptor antagonists: A medicinal chemistry update focusing the therapy of inflammatory diseases. European Journal of Pharmacology, p. 175999, 2023.

Doi://doi.org/10.1016/j.ejphar.2023.175999

Marinho, Ygor; Villarreal, Elizabeth S.; Aboagye, Sammy Y.; Williams, David L.; Sun, Jun; Silva, Claudia L. M.; Lutz, Sarah E.; Oliveira, Suellen D.. Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut–lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression. v. 14, p. 1254762, 2023.

Doi: //doi.org/10.3389/fimmu.2023.1254762

Menezes, Camilla A.; Montresor, Langia C.; Jangola, Soraya T. G.; Mattos, Aline C. de; Domingues, Ana L. C.; Júnior, Arnaldo M.; Silva, Clélia C. M.; Barbosa, Constança S.; Mendonça, Cristiane L. F. de; Massara, Cristiano L.; Fonseca, Cristina T.; Oliveira, Edward J. de; Gomes, Elainne C. de S.; Silva, Elizângela F. da; Bezerra, Fernando S. de M.; Silva-Júnior, Floriano P.; Siqueira, Isadora C. de; Silva, José R. M. e; Heller, Leo; Farias, Leonardo P.; Beck, Lilian C. N. H.; Santos, Mariana C. S.; Lima, Mariana G.; Mourão, Marina de M.; Enk, Martin J.; Fernandez, Monica A.; Katz, Naftale; Carvalho, Omar dos S.; Parreiras, Patrícia M.; Neves, Renata H.; Gava, Sandra G.; Oliveira, Sheilla A. de; Thiengo, Silvana C.; Favre, Tereza C.; Graeff-Teixeira, Carlos; Pieri, Otávio S.; Caldeira, Roberta L.; Silva-Pereira, Rosiane A. da; Rocha, Roberto S.; Oliveira, Ricardo R.. FioSchisto’s expert perspective on implementing WHO guidelines for schistosomiasis control and transmission elimination in Brazil. Frontiers in Immunology, v. 14, 2023.

Doi: 10.3389/fimmu.2023.1268998

Menozzi, Cheyene A. C.; França, Rodolfo R. F.; Luccas, Pedro H.; Baptista, Mayara dos S.; Fernandes, Tácio V. A.; Hoelz, Lucas V. B.; Junior, Policarpo A. S.; Murta, Silvane M. F.; Romanha, Alvaro; Galvão, Bárbara V. D.; Macedo, Marcela de O.; Goldstein, Alana da C.; Araujo-Lima, Carlos F.; Felzenszwalb, Israel; Nonato, Maria C.; Castelo-Branco; Frederico S.; Boechat, Núbia. Anti-Trypanosoma cruzi Activity, Mutagenicity, Hepatocytotoxicity and Nitroreductase Enzyme Evaluation of 3-Nitrotriazole, 2-Nitroimidazole and Triazole Derivatives. Molecules, v. 28, n. 22, p. 7461, 2023.

Doi: 10.3390/molecules28227461 

Merlo, Eduardo; Zimerman, Jeanini; dos Santos, Flávia C. F.; Zanol, Jordana F.; da Costa, Charles S.; Carneiro, Pedro H.; Miranda-Alves, Leandro; Warner, Genoa R.; Graceli, Jones B.. Subacute and low dose of tributyltin exposure leads to brown adipose abnormalities in male rats. Toxicol Lett., v. 376, p. 26-28, 2023.

Doi: 10.1016/j.toxlet.2023.01.003

Monte, Fernanda B. de M.; Montangnoli, Tadeu L.; Dematté, Bruno E.; Gubert, Fernanda; Ventura, Vitória S.; Silva, Jaqueline S. da; Trachez, Margarete M.; Mendez-Otero, Rosalia; Zapata-Sudo, Gisele. Antinociceptive Effect of the Combination of a Novel α4β2* Agonist with Donepezil in a Chronic Pain Model. Biomedicines, v. 11, n. 12, p. 3249, 2023.

Doi://doi.org/10.3390/biomedicines11123249

Montagnoli, Tadeu L.; De Oliveira, Daniela R.; Fraga, Carlos A. M.. Therapeutic Perspectives on ROCK Inhibition for CerebralCavernous Malformations. Kinases Phosphatases, v. 1, p. 72-96, 2023.

Doi: 10.3390/kinasesphosphatases1010006

Moreira-Souza, Aline, C. A.; Nanini, Hayandra F.; Rangel, Thuany P.; Da Silva, Sthefani R. B.; Damasceno, Beatriz P.; Ribeiro, Beatriz E.; Cascabulho, Cynthia M.; Thompson, Fabiano; Leal, Camila; Santana, Patrícia T.; Rosas, Siane L. B.; de Andrade, Kívia Q.; Silva, Cláudia l. M.; Vommaro, Rossiane C.; de Souza, Heitor S. P.; Coutinho-Silva, Robson. P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity of Toxoplasma gondii-Induced Ileitis. Biomedicines, v. 11, p. 555, 2023.

Doi: 10.3390/biomedicines11020555

Oliveira, Maria C. B. de; Oliveira-Melo, Paolo; Silva, Marcos H. G. da; Silva, Flávio S. da; Silva, Felipe A. C. da; Araujo, Bruno V. S. de; Oliveira, Moacir F. de; Correira, Aristides T.; Sakamoto, Sidnei M.; Valença, Samuel S.; Lanzetti, Manuela; Schmidt, Martina; Kennedy-Feitosa, Emanuel. Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. Antioxidants, v. 12, n. 6, p. 1258, 2023. 

Doi: 10.3390/antiox12061258 

Oliveira, Nathália F.; Monteiro, Matheus M.; Mainieri, Nathália S.; Tamura, Augusto; Pereira, Letícia M.; Crepaldi, Leticia D.; Coutinho-Silva, Robson; Savio, Luiz E. B.; Silva, Claudia L. M.. P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis. Frontiers in Immunology, v. 14, p. 1328897, 2023.

Doi: 10.3389/fimmu.2023.1328897

Oliveira, Pamella C. O. de; Ceroullo, Millena S.; Santos, Mayane B. dos; Medeiros, Pedro R. C.; Marques, Bruno C. B.; Tinoco, Luzineide W.; Souza, Maria C. B. V. de; Boechat, Fernanda da C. S.; Moraes, Marcela C. de; Nucleoside hydrolase immobilized on magnetic particles as a tool for onflow screening and characterization of inhibitors. Journal of Pharmaceutical and Biomedical Analysis, v. 235, p. 115589, 2023.

Doi: //doi.org/10.1016/j.jpba.2023.115589

Oliveira, Pamella C. O. de; Tinoco, Luzineide T.; Cardoso, Carmen L.; Cass, Quezia B.; Moraes, Marcela C. de. Advances in screening assays for identifying cholinesterase ligands. TrAC Trends in Analytical Chemistry, p. 117362, 2023.

Doi: //doi.org/10.1016/j.trac.2023.117362

Peres, Rodrigo A. S.; Silva-Aguiar, Rodrigo P.; Teixeira, Douglas E.; Peruchetti, Diogo B.; Alves, Sarah A. S.; Leal, Anna B. C.; Castro, Guilherme F.; Ribeiro, Natalia B. S.; Guimarães, Fernanda V.; Pinheiro, Ana A. S.; Silva, Patrícia M. R. E.; Martins, Marco A.; Caruso-Neves, Celso. Gold nanoparticles reduce tubule-interstitial injury and proteinuria in a murine model of subclinical acute kidney injury. Biochim. Biophys Acta Gen. Subj., v. 1867, p. 130414, 2023.

Doi: 10.1016/j.bbagen.2023.130314

Pinheiro, Pedro de S. M.; Franco, Lucas S.; Fraga, Carlos A. M.; The Magic Methyl and Its Tricks in Drug Discovery and Development. Pharmaceuticals, v. 16, p. 1157, 2023.

Doi: 10.3390/ph16081157 

Ribeiro, Bianca C. de S.; Faria, Regina V. de C.; Nogueira, Jeane de S.; Valença, Samuel S.; Chen, Lin; Romana-Souza, Bruna. Olive oil promotes the survival and migration of dermal fibroblasts through Nrf2 pathway activation. Lipids, v. 58, p. 59-68, 2023.

Doi: 10.1002/lipd.12363

Saramago, Luiz C.; Santana, Marcos V.; Gomes, Bárbara F.; Dantas, Rafael F.; Senger, Mario R.; Borges, Pedro H. O.; Ferreira, Vivian N. dos S.; Rosa, Alice dos S.; Tucci, Amanda R.; Miranda, Milene D.; Lukacik, Petra; Strain-Damerell, Claire; Owen, David; Walsh, Martin A.; Ferreira, Sabrina B.; Silva-Jr, Floriano P.. AI-Driven Discovery of SARS-CoV-2 Main Protease Fragment-like Inhibitors with Antiviral Activity In Vitro. J. Chem. Inf. Model., 2023.

Doi: 10.1021/acs.jcim.3c00409

Silva, Camila O. da; Nogueira, Jeane de S.; Nascimento, Adriana P. do; Victoni, Tatiana; Bártholo, Thiago P.; Costa, Cláudia H. da; Costa, Andrea M. A.; Valença, Samuel dos S.; Schmidt, Martina; Porto, Luís C.. COPD Patients Exhibit Distinct Gene Expression, Accelerated Cellular Aging, and Bias to M2 Macrophages. International Journal of Molecular Sciences, v. 24, n. 12, p. 9913, 2023.

Doi: 10.3390/ijms24129913 

Silva, Ricardo C. da; Teixeira, Mariana P.; Paiva, Luciana S. de; Miranda-Alves, Leandro. Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin. Toxics, v. 11, n. 8, p. 696, 2023.

Doi: 10.3390/toxics11080696 

Souto, Arthur C.; Tempone, Matheus H.; Golçalves, Lyslie A. C.; Borges-Martins, Vladimir P. P.; Peixoto-Rodrigues, Maria C.; Damascena, Ana C. O.; Ferraz, Gabriel; Manhães, Alex C.; Castro, Newton G.; de Melo, Ricardo A. R.; Ventura, Ana L. M.; Kubrusly, Regina C. C.. NMDA Receptor Activation and Ca2+/PKC Signaling in Nicotine-Induced GABA Transport Shift in Embryonic Chick Retina. Neurochemical Research, v. 48, p. 1, 2023.

Doi: 10.1007/s11064-023-03870-7

Souza, Isis N. O.; Andrade, Brenda S.; Frost, Paula S.; Neris, Romulo L. S.; Gavino-Leopoldino, Daniel; Da Poian, Andrea T.; Assunção-Miranda, Iranaia; Figueiredo, Claudia P.; Clarke, Julia R.; Neves, Gilda A.. Different outcomes of neonatal and adult Zika virus infection on startle reflex and prepulse inhibition in mice. Behav. Brain Res., v. 451, p. 114519, 2023.

Doi: 10.1016/j.bbr.2023.114519

Tarabini, Flavia; Rozemberg, Laila; Zapata-Sudo, Gisele; Braz, Andre. A Novel Hyaluronic Acid Filling Technique for Restoring Volume of the Labia Majora. Cureus, v. 15, n. 9, 2023.

Doi: 10.7759/cureus.45728

Teixeira-Alves, Lyzes R.; Nobre, Camila C. G.; Reis, Evelyn M.; Miranda-Alves, Leandro; Junior, Clemilson B.. Bosentan Attenuates Sickle Cell Disease Erythrocyte HbS Polymerization and Impaired Deformability Induced by Endothelin-1. Canadian Journal of Physiology and Pharmacology, 2023.

Doi: 10.1139/cjpp-2022-0012

Teixeira-Cruz, Jhonatha M.; Martins-Ferreia, Jainne; Monteiro-Machado, Marcos; Strauch, Marcelo A.; de Moraes, João A.; Amaral, Luciana S.; Valente, Raphael C.; Melo, Paulo A.; Quintas, Luis E. M.. Heparin prevents the cytotoxic activity of Bothrops jararacussu and Apis mellifera venoms in renal cells. Toxicon, v. 223, p. 107011, 2023.

Doi: 10.1016/j.toxicon.2022.107011

Zimerman, Jeanini; Niño, Oscar M. S.; da Costa, Charles S.; Zanol, Jordana F.; Comério, Milena; de Souza, Letícia N. da G.; Miranda-Alves, Leandro; Miranda, Rosiane A.; Lisboa, Patrícia C.; Camilo, Tays A.; Rorato, Rodrigo; Alves, Guilherme A.; Frazão, Renata; Zomer, Helena D.; Freitas-Lima, Leandro C.; Graceli, Jones B.. Subacute high-refined carbohydrate diet leads to abnormal reproductive control of the hypothalamic-pituitary axis in female rats. Reproductive Toxicology, v. 119, p. 108410, 2023.

Doi: 10.1016/j.reprotox.2023.108410

2022

de Almeida, Lana R.; Alves, Marina A.; Mastella, Ana M. O.; Garret, Rafael; Pereira, Maria J. R.. Neotropical mustelids: fecal metabolome diversity and its potential for taxonomic discrimination. Integrative Zoology, 2022.

Doi: 10.1111/1749-4877.12645

Amorim, Carolinne S.; Moraes, João A.; Magdalena, Ingrid J.; López, Sheila G.; Carneiro, Ana C. D.; Nunes, Isabelle K. C.; Pizzatti, Luciana; Sardela, Vinícius, F.; Neto, Aquino F. R.; Mirotti, Luciana C.; Pereira, Henrique M. G.; Renovato-Martins, Mariana. Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes. Frontiers in Immunology, v. 13, p. 1, 2022.

Doi: 10.3389/fimmu.2022.833286

Amorim, Carolinne S.; Docasar, Clara L.; Guimarães-Bastos, Daniel; Frony, Ana C.; Barja-Fidalgo, Christina; Renovato-Martins, Mariana; Moraes, João A.. Extracellular Vesicles Derived from MDA-MB-231 Cells Trigger Neutrophils to a Pro-Tumor Profile. Cells, v. 11, p. 1875, 2022.

Doi: 10.3390/cells11121875

Andrade, Marcelle N.; Melo-Paiva, Francisca; Teixeira, Mariana P.; de Lima-Junior, Nieldson C.; Soares, Paula; Graceli, Jones B.; de Carvalho, Denise P.; Morris, Eduardo A. R.; Ferreira, Andrea C. F.; Miranda-Alves, Leandro. Environmentally relevant dose of the endocrine disruptor tributyltin disturbs redox balance in female thyroid gland. Molecular and Cellular Endocrinology, v. 553, p. 111689, 2022.

Doi: 10.1016/j.mce.2022.111689

Barbosa, G.; Gelves, Luis G. V.; Costa, Caroline M. X.; Franco, Lucas S.; De Lima, João A. L.; Aparecida-Silva, Cristiane; Teixeira, John D.; Mermelstein, Cláudia S.; Barreiro, Eliezer J.; Lima, Lídia M.. Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs. Pharmaceuticals, v. 15(8), p. 1-22, 2022.

Doi: //doi.org/10.3390/ph15080913

Brasiel, Poliana G. A.; Guimarães, Fernanda V.; e Silva, Patricia M. R.; Bou-Habib, Dumith C.; Carvalho, Vinicius F.. Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials. Journal of Immunology Research, v. 2022, 2022.

Doi: 10.1155/2022/8191253

Cardoso, Tassya C.; Rocha, Marianna A.; Monteiro, Matheus M. L. V.; Alves, Vinícius S.; Savio, Luiz E. B.; Silva, Cláudia L. M.. The blockage of downstream P2Y2 receptor signaling inhibits the prostate cancer cell adhesion to endothelial cells. Life Sciences, v. 306(1), p. 120793, 2022.

Doi: 10.1016/j.lfs.2022.120793

Costa, Bianca; Corrêa, Luana B.; e Silva, Patricia M. R.; de Sá, Yago A. P. J.; Guimarães, Fernanda V.; Alencar, Luciana M. R.; Simões, Rafael L. Helal-Neto, Edward; Ricci-Júnior, Eduardo; Henriques, Maria G. M. O.; Rosas, Elaine C.; Santos-Oliveira, Ralph. Using pure Fucoidan and radiolabeled Fucoidan (99mTc-Fucoidan) as a new agent for inflammation diagnosis and therapy. Food Hydrocolloids for Health, v. 2, p. 10049, 2022.

Doi: 10.1016/j.fhfh.2021.100049

Caruso, Lucas ; Nadur, N. Fonseca ; Da Fonseca, M. Brandão ; Peixoto, De Almeida, Larissa; Lacerda, R. Barbosa; Graebin, C. Stephan; Kümmerle, Arthur Eugen. The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two(or more) Birds on One Stone. Current Topics in Medicinal Chemistry, v. 22, p. 366-394, 2022.

Doi:10.2174/1568026622666220201151248

Costa, Tamara G. F.; Oliveira, Marina M.; Toledo, Marina M.; Santos, Helio B.; Thome, Ralph G.; Cortes, Vanessa F.; Santos, Herica L.; Quintas, Luis E. M.; Fontes, Carlos F. L.; Barbosa, Leandro A.. Effect of Fe3+ on Na,K-ATPase: Unexpected activation of ATP hydrolysis. Biochimica et Biophysica Acta (BBA), v. 1864, p. 183868, 2022.

Doi: 10.1016/j.bbamem.2022.183868

Cunha, Thayssa T. S.; Silva, Rafaela R.; Rodrigues, Daniel A.; Pinheiro, Pedro S. M.; Kronenberger, T.; Sant’Anna, Carlos M. R.; Noël, François. Fraga, Carlos A. M.. Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases. Biomolecules, v. 12(8), p. 1-18, 2022.

Doi: 10.3390/biom12081112 

Dantas, Rafael F.; Torres-Santos, Eduardo; Silva-Júnior, Floriano P.. Past and future of trypanosomatids high-throughput phenotypic screening. Mem Inst Oswaldo Cruz, v. 117, p. e210402, 2022.

Doi: 10.1590/0074-02760210402  

Faria, Jessica V.; Passos, Fernanda P.Z.; da Costa, Paulo H.A.; de Oliveira, Andressa P.; Cruz, Yasmin O.D. da; Castelo-Branco, Frederico S.; Lourenço, Maria C.S.; Murta, Silvane M.F.; Junior, Policarpo A.S.; Bernardino, Alice M.R.; Bastos, Monica M.; Boechat, Nubia. Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis. Medicinal Chemistry, v. 18, p. 701-709, 2022.

Doi: 10.2174/1573406418666211116144952

de Faria, Rachel A.; Oliveira, Pamella C. O.; de Carvalho, Mariana D. P.; Peixoto, Bruno S.; Severino, Vanessa G. P.; Tinoco, Luzineide W.; Rodrigues, Silvana V.; de Moraes, Marcela C.. High-resolution inhibition profiling and ligand fishing for screening of nucleoside hydrolase ligands in Moringa oleifera Lamarck. Journal of Pharmaceutical and Biomedical Analysis, v. 211, p. 114614, 2022.

Doi: 10.1016/j.jpba.2022.114614

França, Patrícia R. C.; Lontra, Anna C. P.; Fernandes, Patricia D.. Endometriosis: A Disease with Few Direct Treatment Options. Molecules, v. 27, p. 4034, 2022.

Doi: 10.3390/molecules27134034

Ferreira, Tatiana P. T.; Guimarães, Fernanda V.; Sá, Yago A. P. J.; Ribeiro, Natalia B. S.; de Arantes, Ana C. S.; Carvalho, Vinicius F.; Sousa, Lirlândia P.; Perretti, Mauro; Martins, Marcos A.; e Silva, Patricia M. R.. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, p. 759, 2022.

Doi: 10.3390/cells11050759

Figueiredo-Junior, Alexsandro T.; Valença, Samuel S.; Fintonelli, Priscilla V.; dos Anjos, Francisca F.; de Brito-Gitirana, Lycia; Takiya, Christina M.; de Deus, Manuella L. D.. Treatment with Bixin-Loaded Polymeric Nanoparticles Prevents Cigarette Smoke-Induced Acute Lung Inflammation and Oxidative Stress in Mice. Antioxidants, v. 11, p. 1293, 2022.

Doi: 10.3390/antiox11071293

Gouvêa, Marcos M.; de Carvalho, Renata C.; Castelo-Branco, Frederico C.; Boechat, Nubia; Netto, Annibal D. P.; Marques, Flávia F. C.. The cleavage kinetics of hydrazide derivatives of isoniazid by HPLC-UV/DAD and its impact on activity against Mycobacterium tuberculosis.  Journal of Chromatography B, v. 1188, p. 123080, 2022.

Doi: 10.1016/j.jchromb.2021.123080

Lamichhane, Santosh; Sen, Partho; Dickens, Alex M.; Alves, Marina A.; Härkönen, Taina; Honkanen, Jarno; Vatanen, Tommi; Xavier, Ramnik J.; Hyötyläinen, Tuulia; Knip, Mikael; Orešič, Matej. Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes. Cell Reports Medicine, p. 100762, 2022.

Doi: 10.1016/j.xcrm.2022.100762

Lara, Lucienne S.; Gonzalez, Alexis A.; Hennrikus, Mathew T.; Prieto, Minofa C.. Hormone-dependent regulation of renin and effects on prorenin receptor signaling in the collecting duct. Current Hypertens Review, 2022.

Doi: 10.2174/1573402118666220216105357

Leite, Jacqueline A.; Pôças, Elisa; Maia, Gisele S.; Barbosa, Leandro; Quintas, Luis E. M.; Kawamoto, Elisa M.; da Silva, Maria L. C.; Scavone, Cristoforo; de Carvalho, Luciana E. D.. Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies. Frontiers in Pharmacology, v. 13, p. 916312, 2022.

Doi: 10.3389/fphar.2022.916312

Leser, Felipe S.; Fiuza, Diogo N.; Miranda-Alves, Leandro. Importance of students congresses for medical training: A pioneer experience at Federal University of Rio de Janeiro. Revista Brasileira de Educação e Saúde-REBES, v. 11, p. 464-475, 2022.

Doi: 10.18378/rebes.v11i4.8632

Mansoldo, Felipe R. P.; Garrett, Rafael; Cardoso, Veronica S.; Alves, Marina A.; Vermelho, Alane B.. Metabology: Analysis of metabolomics data using community ecology tools. Analytica Chimica Acta, v. 1232, p. 340469, 2022.

Doi: 10.1016/j.aca.2022.340469

Mendes, Ana B. A.; Motta, Nadia A. V.; Lima, Gabriel F.; Autran, Lis J.; Brazão, Stephani C.; Magliano, D'Angelo C.; Sepúlveda-Fragoso, Vinícius; Scaramello, Christiane B. V.; Graceli, Jones B.; Miranda-Alves, Leandro; Brito, Fernanda C. F.. Evaluation of the effects produced by subacute tributyltin administration on vascular reactivity of male wistar rats. Toxicology, v. 465, p. 153067, 2022.

Doi: 10.1016/j.tox.2021.153067

Moreira, Lorrane K. S.; Silva, Rafaela R.; da Silva, Dayane M.; Mendes, Mirella A. S.; de Brito, Adriane F.; de Carvalho, Flávio S.; Sanz, Germán; Rodrigues, Marcella F.; da Silva, Artur C. G.; Thomaz, Douglas V.; de Oliveira, Valéria; Vaz, Boniek G.; Lião, Luciano M.; Valadares, Marize C.; Gil, Eric S.; Costa, Elson A.;  Noël, François; Menegatti, Ricardo. Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice. Behavioural Brain Research, v. 417(24), p. 113582, 2022.

Doi: 10.1016/j.bbr.2021.113582

Nunes, Bruno; Pópulo, Helena; Lopes, José M.; Reis, Marta; Nascimento, Gilvan; Nascimento, Ana G.; Fernandes, Janaína; Faria, Manuel; de Carvalho, Denise P.; Soares, Paula; Miranda-Alves, Leaandro. Connexin Expression in Pituitary Adenomas and the Effects of Overexpression of Connexin 43 in Pituitary Tumor Cell Lines. Genes, v. 13, p. 674, 2022.

Doi: 10.3390/genes13040674

Oliveira, Andressa; Moura, Stefany; Pimentel, Luiz; Neto, João; Dantas, Rafael; Silva-Júnior, Floriano P.; Bastos, Monica; Boechat, Nubia. New Imatinib Derivatives with Antiproliferative Activity against A549 and K562 Cancer Cells. Molecules, v. 27(3), p. 750, 2022.

Doi: 10.3390/molecules27030750

Ortiz, Cindy J. C.; Silva, Matheus F.; Pruccoli, Letizia; Nadur, Nathália F.; De Azevedo, Luciana L.; Kümmerle, Arthur E.; Guedes, Isabella A.; Dardenne, Laurent E.; Coelho, Luiz F. L.; Guimarães, Marcos J.; Da Silva, Fernanda M. R.; Castro, Newton; Gontijo, Vanessa S.; Rojas, Viviana C. T.; De Oliveira, Merelym K.; Vitela, Fabiana C.; Giusti-Paiva, Alexandre; Barbosa, Gisele; Lima, Lídia M.; Pinheiro, Gabriel B.; Veras, Letícia G.; Mortari, Márcia R.; Tarozzi, Andrea; Júnior, Cláudio V.. Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation. RSC Medicinal Chemistry, v. 13, p. 568-584, 2022.

Doi: 10.1039/D1MD00374G

Portovedo, Sérgio; Neto, Leonardo V.; Soares, Paula; de Carvalho, Denise P.; Takiya, Christina M.; Miranda-Alves, Leandro. Aggressive nonfunctioning pituitary neuroendocrine tumors. Brain Tumor Pathology, 2022.

Doi: 10.1007/s10014-022-00441-6

de Queiroz, Aline C.; Barbosa, G.; de Oliveira, Victória R. T.; Alves, Hélio M.; Alves, Marina A.; Carregaro, V.; da Silva, João S.; Barreiro, Eliezer J.; Alexandre-Moreira, Magna S.; Lima, Lídia M.. Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity. Plos One, v. 17(6), p. e0269447, 2022.

Doi: 10.1371/journal.pone.0269447

Rodrigues-Pereira, Paula; Andrade, Marcelle N.; Santos-Silva, Ana P.; Teixeira, Mariana P.; Soares, Paula; Graceli, Jones B.; de Carvalho, Denise P.; Dias, Glaecir R. M.; Ferreira, Andrea C. F.; Miranda-Alves, Leandro. Subacute and low-dose tributyltin exposure disturbs the mammalian hypothalamus-pituitary-thyroid axis in a sex-dependent manner. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 254, p. 109279, 2022.

Doi: 10.1016/j.cbpc.2022.109279

Santos, Carine; Pimentel, Luiz; Cazian, Henayle; Oliveira, Andressa; Silva-Júnior, Floriano P.; Dantas, Rafael; Hoelz, Lucas; Marinho, Debora; Cunha, Anna; Bastos, Monica; Boechat, Nubia. Hybrids of Imatinib with Quinoline: Synthesis, Antimyeloproliferative Activity Evaluation, and Molecular Docking. Pharmaceuticals, v.15(3), p. 309, 2022.

Doi: 10.3390/ph15030309

Santos, Stephanie A. C. S.; Persechini, Pedro M.; Henrique-Santos, Bianca M.; Bello-Santos, Victória G.; Castro, Newton C.;  de Sousa, Júlia C.; Genta, Fernando A.; Santiago, Marcelo F.; Coutinho-Silva, Robson; Savio, Luiz E. B.; Kurtenbach, Eleonora. P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels. Frontiers in Immunology, v. 13, p. 752105, 2022.

Doi: 10.3389/fimmu.2022.752105

Serra, Magda F.; Cotias, Amanda C.; Pimentel, Andreza S.; de Arantes, Ana C. S.; Pires, Ana L. A.; Lanzetti, Manuella; Hickmann, Jandir M.; Barreto, Emiliano; Carvalho, Vinicius F.; Silva, Patrícia M. R.; Cordeiro, Renato S. B.; Martins, Marco A.. Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways. v. 11, p. 1659, 2022.

Doi: 10.3390/antiox11091659

Silva, Grazielle F.; da Silva, Jaqueline S.; de Alencar, Allan K. N.; da Silva, Marina M. C.; Montagnoli, Tadeu L.; Rocha, Bruna S.; de Freitas, Rosana H. C. N.; Sudo, Roberto T.; Fraga, Carlos A. M.; Zapata-Sudo, Gisele. Novel p38 Mitogen-Activated Protein Kinase Inhibitor Reverses Hypoxia-Induced Pulmonary Arterial Hypertension in Rats. Pharmaceuticals, v.15(7), p. 1-16, 2022.

Doi: 10.3390/ph15070900

Silva, Girlaine P.; Fernandes, Daniele C.; Vigliano, Mariana V.; Pinto, Fabiana A.; Fonseca, Eduardo N.; Santos, Shirley V. M.; Marques, Paulo R.; Gayer, Carlos R. M.; Velozo, Leosvaldo S. M.; de Lima, Cleverton K. F.; de Miranda, Ana L. P.; Justo, Maria G.; Sabino, Kátia C. C.; Coelho, Marsen G. P.. Echinodorus macrophyllus: Hydroxycinnamoyl derivatives reduces neutrophil migration through modulation of cytokines, chemokines, and prostaglandin in the air-pouch model. Journal of Ethnopharmacology, v. 284(10), p. 114757, 2022.

Doi: 10.1016/j.jep.2021.114757

da Silva, Jaqueline S.; Gonçalves, Renata G. J.; Vasques, Juliana F.; Rocha, Bruna S.; Nascimento-Carlos, Bianca; Montagnoli, Tadeu L.; Mendez-Otero, Rosália; de Sá, Mauro P. L.; Zapata-Sudo, Gisele.  Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy. Cells, v. 11, p. 240, 2022.

Doi: 10.3390/cells11020240

de Souza, Hygor M. R.; Guedes, Jéssica S.; Freitas, Rosana H. C.; Gelves, Luis G. V.; Fokoue, Harold H.;  Sant’Anna, Carlos M. R.; Barreiro, Eliezer J.; Lima, Lídia M.. Comparative chemical and biological hydrolytic stability of homologous esters and isosteres. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37(1), p. 718-727, 2022.

Doi: 10.1080/14756366.2022.2027933

Valença, Samuel S.; Dong, Brittany E.; Gordon, Elizabeth M.; Sun, Ramon C.; Waters, Christopher M.. ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology, v. 66, p. 484-496, 2022.

Doi: 10.1165/rcmb.2021-0465OC

Valença, Helber M.; e Silva, Cyntia P.; Gitirana, Lycia B.; Valença, Samuel S.; Lanzetti, Manuella. Beneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice. Phytotherapy Research, v. 36, p. 1032-1042, 2022.

Doi: 10.1002/ptr.7377

Viana, Max D. M.; De Lima, Alyne A.; Neto, Geraldo J. S.; Da Silva, Suellen M. A.; Leite, Anderson B.; Dos Santos, Elane C.; Bassi, Ênio J.; Campesatto, Eliane A.; De Queiroz, Aline C.; Barreiro, Eliezer J.; Lima, Lídia M.; Alexandre-Moreira, Magna S.. LASSBio-596: a New Pre-clinical Candidate for Rheumatoid Arthritis?, v. 45, p. 528-543, 2022.

Doi: 10.1007/s10753-021-01564-2

Viana, Elaine O. R.; da Silva, Marília J.; da Silva, Bernadete P.; Tinoc, Luzineide W.; Parente, José P.. Two new triterpenoid saponins from the flowers of Albizia lebbeck. Natural Product Research, p. 1-10, 2022.

Doi: 10.1080/14786419.2022.2031184

Viel, Amanda M.; Figuereido, Célia C. M.; Granero, Filipe O.; Silva, Luciana P.; Ximenes, Valdecir F.; Godoy, Thais M.; Quintas, Luis E. M.; da Silva, Regildo M. G.. Antiglycation, antioxidant and cytotoxicity activities of crude extract of Turnera ulmifolia L. before and after microencapsulation process. Journal of Pharmaceutical and Biomedical Analysis, v. 219, p. 114975, 2022.

Doi: 10.1016/j.jpba.2022.114975

Zapata-Sudo, Gisele.  Riociguate: Uma Alternativa para Tratar a Hipertensão Pulmonar. Arquivos Brasileiros de Cardiologia, v. 119, p. 111-112, 2022.

Doi: 10.36660/abc.20220305

 

2021

Franco, Lucas S. ; Maia, Rodolfo C. ; Barreiro, Eliezer J. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M PRO ) through in silico screening supported by molecular docking and a fragment-based pharmacophore model. Rsc Medicinal Chemistry, v. 12, p. 110-119, 2021. 

Doi: 10.1039/D0MD00282H

 

Rodrigues, Daniel A. ; Pinheiro, Pedro S. M. ; Fraga, Carlos A. M.  Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol-3-kinase (PI3K): Current and Future Prospects. ChemMedChem, v. 16, p. 448-457, 2021.

Doi://10.1002/cmdc.202000643

Guerra, Fabiana Sélos ; Rodrigues, Daniel Alencar ; Fraga, Carlos Alberto Manssour ; Fernandes, Patricia Dias . Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer. Pharmaceuticals, v. 14, p. 387, 2021.

Doi://10.3390/ph14050387

Lima, Lidia Moreira; Da Silva, Tiago Fernandes ; Da Silva Monteiro, Carlos Eduardo ; Aparecida-Silva, Cristiane ; Bispo Júnior, Walfrido ; De Queiroz, Aline Cavalcanti ; Alexandre-Moreira, Magna Suzana ; Zapata-Sudo, Gisele ; Barreiro, Eliezer J.  Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514. Molecules, v. 26, p. 4828, 2021.

Doi://10.3390/molecules26164828

Viana, Max Denisson Maurício ; De Lima, Alyne Almeida ; Da Silva Neto, Geraldo José ; Da Silva, Suellen Maria Albuquerque ; Leite, Anderson Brandão ; Dos Santos, Elane Conceição ; Bassi, Ênio José ; Campesatto, Eliane Aparecida ; De Queiroz, Aline Cavalcanti ; Barreiro, Eliezer Jesus ; Lima, Lidia Moreira ; Alexandre-Moreira, Magna Suzana . LASSBio-596: a New Pre-clinical Candidate for Rheumatoid Arthritis?. Inflammation, v. 25, p. 1, 2021

Doi://10.1007/s10753-021-01564-2

Lorenzoni, Ricardo ; Vidor Contri, Renata ; Kleiton Freitas De Lima, Cleverton ; Barreto, Fabiano ; Verlindo De Araujo, Bibiana ; Raffin Pohlmann, Adriana ; Luísa Palhares De Miranda, Ana ; Dalla Costa, Teresa ; Stanisçuaski Guterres, Silvia . Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal Of Pharmaceutics, v. 596, p. 120294, 2021.

Doi://10.1016/j.ijpharm.2021.120294

Robba, Chiara ; Battaglini, Denise ; Ball, Lorenzo ; Valbusa, Alberto ; Porto, Italo ; Della Bona, Roberta ; La Malfa, Giovanni ; Patroniti, Nicolò ; Brunetti, Iole ; Loconte, Maurizio ; Bassetti, Matteo ; Giacobbe, Daniele R. ; Vena, Antonio ; Silva, Claudia Lucia M. ; Rocco, Patricia R. M. ; Pelosi, Paolo . Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine, v. 10, p. 140, 2021.

Doi://10.3390/jcm10010140

Santana, Marcos V. S. ; Silva-Jr, Floriano P. De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning. BMC Chemistry, v. 15, p. 8, 2021.

Doi://10.1186/s13065-021-00737-2

Evangelista, Tereza Cristina Santos ; Delarmelina, Maicon ; Addla, Dinesh ; Allão, Rafael A. ; Kaiser, Carlos Roland ; CARNEIRO, JOSÉ WALKIMAR DE M. ; SILVA-JR, FLORIANO PAES ; Ferreira, Sabrina Baptista . Influence of temperature for the azide displacement in benzodiazepine derivatives: Experimental and DFT study of competing SN1, SN2 and double SN2 reaction pathways. Tetrahedron Letters, v. 68, p. 152937, 2021.

Doi: 10.1016/j.tetlet.2021.152937

Cadoná, Francine C. ; Dantas, Rafael Ferreira ; De Mello, Gabriela Haas ; Silva-Jr, Floriano Paes . Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin. Critical Reviews In Food Science And Nutrition, v. -, p. 1-20, 2021.

Doi: 10.1080/10408398.2021.1913091

Moreira-Filho, J. T. ; De Souza Neto, Lauro Ribeiro ; Gomes, B.F. ; Dantas, R. F. ; Neves, Bruno J ; Furnham, Nicholas ; Owens, R.J. ; Silva-Junior, Floriano Paes ; Andrade, Carolina Horta . Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence. Frontiers in Immunology, v. 12, p. 1-29, 2021.

Doi:10.3389/fimmu.2021.642383

Gasparotto, Juciano ; Senger, Mario Roberto ; Telles De Sá Moreira, Emilio ; Brum, Pedro Ozorio ; Carazza Kessler, Flávio Gabriel ; Peixoto, Daniel Oppermann ; Panzenhagen, Alana Castro ; Ong, Lin Kooi ; Campos Soares, Marlene ; Reis, Patricia Alves ; Schirato, Giuliana Viegas ; Góes Valente, Walter César ; Araújo Montoya, Bogar Omar ; Silva, Floriano P. ; Fonseca Moreira, José Claudio ; Dal-Pizzol, Felipe ; Castro-Faria-Neto, Hugo C. ; Gelain, Daniel Pens . Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease. Journal Of Biological Chemistry, v. 1, p. 100979, 2021.

Doi: 10.1016/j.jbc.2021.100979

Paes Silva-Jr, Floriano. Combating Neglected Diseases in the Post-COVID-19 World. Revista Virtual De Química, v. 13, p. 308-309, 2021.

Pimentel, Luiz Claudio Ferreira ; Hoelz, Lucas Villas Boas ; Canzian, Henayle Fernandes ; Branco, Frederico Silva Castelo ; De Oliveira, Andressa Paula ; Campos, Vinicius Rangel ; Júnior, Floriano Paes Silva ; Dantas, Rafael Ferreira ; Resende, Jackson Antônio Lamounier Camargos ; Cunha, Anna Claudia ; Boechat, Nubia ; Bastos, Mônica Macedo . (Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia. Beilstein Journal of Organic Chemistry, v. 17, p. 2260-2269, 2021.

Doi: 10.3762/bxiv.2021.44.v1

Valadares, J. M. M. ; Bajaj, S. O. ; Li, H. ; Wang, H. L. ; Silva, S. C. ; Garcia, I. J. P. ; Pereira, D. G. ; Azalim, P. ; Quintas, L. E. M. ; Noël, François ; Cortes, V. F. ; O?Doherty, G. A. ; Barbosa, L. A.  Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca2+-ATPase. Journal Of Cellular Biochemistry, v. 122, p. 1903-1914, 2021.

Doi: 10.1002/jcb.30150

De Oliveira, Gisele Capanema ; Rocha, Sayonarah Carvalho ; Da Silva Lopes, Miliane Alves ; Paixão, Natasha ; Alves, Silmara Lúcia Grego ; Pessoa, Marco Túlio Corrêa ; Noël, François ; Quintas, Luis Eduardo M. ; Barbosa, Leandro Augusto ; Villar, José Augusto Ferreira Perez ; Cortes, Vanessa Faria . Implications of Synthetic Modifications of the Cardiotonic Steroid Lactone Ring on Cytotoxicity. Journal Of Membrane Biology, v. 1, p. 1, 2021.

Doi: 10.1007/s00232-021-00186-x

 

Pedreira, Júlia Galvez Bulhões ; Silva, Rafaela Ribeiro ; Noël, François G. ; Barreiro, Eliezer J.  Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A2A Receptor. Molecules, v. 26, p. 7364, 2021.

Doi: 10.3390/molecules26237364

Noël, F.; Xexéo, G. ; Mangeli, E. ; Mothé, A. ; Marques, P. ; Kritz, J. ; Blanchard, F. ; Vermelho, H. ; Paiva, B. De . Screener, an educational game for teaching the Drug Discovery and Development process. Brazilian Journal of Medical and Biological Research (on line), v. 54, p. e11786, 2021

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Nascimento, Leandro S. ; Nogueira-Souza, Pâmella D. ; Rocha-Junior, José R.S. ; Monteiro-Machado, Marcos ; Strauch, Marcelo A. ; Prado, Simone A.L. ; Melo, Paulo A. ; Veiga-Junior, Valdir F.  Phytochemical Composition, Antisnake Venom And Antibacterial Activities Of Ethanolic Extract Of Aegiphila Integrifolia (Jacq) Moldenke Leaves. Toxicon, V. 198, P. 121-131, 2021.

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Figueiredo-Junior, Alexsandro Tavares ; Dos Anjos, Francisca De Fátima ; Brito, Francisco Das Chagas De Melo ; Viana, Vicente Galber Freitas ; Valença, Samuel Santos ; Lanzetti, Manuella ; Finotelli, Priscilla Vanessa . Bixin Loaded On Polymeric Nanoparticles: Synthesis, Characterization, And Antioxidant Applications In A Biological System. Applied Nanoscience, V. 11, P. 63-78, 2021.

 

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Sampaio De Holanda, Gustavo ; Dos Santos Valença, Samuel ; Maran Carra, Amabile ; Lopes Lichtenberger, Renata Cristina ; Franco, Olavo Borges ; Ribeiro, Beatriz Elias ; Bittencourt Rosas, Siane Lopes ; Santana, Patricia Teixeira ; Lima Castelo-Branco, Morgana Teixeira ; Pereira De Souza, Heitor Siffert ; Schanaider, Alberto . Sulforaphane And Albumin Attenuate Experimental Intestinal Ischemia-Reperfusion Injury. Journal Of Surgical Research, V. 262, P. 212-223, 2021.

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Cardoso, Aline De Oliveira Pontes ; Pecli E Silva, Cyntia ; Dos Anjos, Francisca De Fátima ; Quesnot, Nicolas ; Valenca, Helber Da Maia ; Cattani-Cavalieri, Isabella ; Brito-Gitirana, Lycia ; Valenca, Samuel Santos ; Lanzetti, Manuella . Diallyl Disulfide Prevents Cigarette Smoke-Induced Emphysema In Mice. Pulmonary Pharmacology & Therapeutics, V. 69, P. 102053, 2021.

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2020

Franco, L.S.; Maia, R.C.; Barreiro, E.J. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (MPRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model. RSC Medicinal Chemistry. 12, 110–119. 

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Silva, N. L. C.; Mota, N. A. V. ; Soares, M. A. ; Araujo, O.M.O.; Espindola, L. C. P. ; Colombo, A. P. V. ; Lopes, R. T. ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.

 

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Rodrigues, D. A.; Pinheiro, P.S.M. ; Sagrillo, F.S. ; Freitas, M.C.R. ; Alves, M.A, ; Thota, S. ; Tinoco, L.W. ; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-Property Relationship Studies of 3-Acyl-Substituted Furans: The Serendipitous Identification and Characterization of a New Non-Classical Hydrogen Bond Donor Moiety. New Journal of Chemistry, v. 44, p. 10994-11005, 2020.

 

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Rodrigues, D. A ; Pinheiro, P. S. M. ; Sagrillo, F. S. ; Bolognesi, M. L. ; FRAGA, C. A. M. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Medicinal Research Reviews, v. 40, p. 2177-2211, 2020.

 

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Cunha, T.T.S.; Souza, F. R.; Pinheiro, P. S.M.; Sant’anna, C. M.R.; NOËL, F.; França, T.C. C.; Fraga, C.A.M. Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin. CNS & Neurological Disorders-Drug Targets, v. 19, p. 437-447, 2020.

 

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Viegas, C. ; Fraga, C. A. M.; Sousa, M. E. ; Tarozzi, A . Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?. Frontiers in Pharmacology, v. 11, p. 609274, 2020.

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Thorstenberg, M. L. ; Martins, M. D. A. ; Figliuolo, V. ; Silva, C.L. M ; Savio, L.E. ; Silva, R.C . P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion. Mediators of Inflammation, v. 2020, p. 1-11, 2020.

 

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Oliveira, N.F.; Silva, C.L.M. Unveiling the potential of purinergic signaling in schistosomiasis treatment. Current Topics in Medicinal Chemistry, v. 20, p. 1, 2020.

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Teixeira, R. G. S.; Pascual, R.; Araújo, K.G.L.; Brito, M. A. ; RIOS, C. ; C., A. F. ; Gandía, L. ; Silva, C. L. M. ; Machado, T. B. ; Santos, Wilson,C. In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone. Natural Product Research. V. 1, p. 1-6, 2020.

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Pauli, F. P.; Martins, J. R.; Paschoalin, T. ; Ionta, M. ; Barbosa, M. L. C. ; Barreiro, E. J.  Novel VEGFR-2 inhibitors with an N</i> -acylhydrazone scaffold. Archiv Der Pharmazie, v. 276, p. e2000130., 2020.

 

Alves, M. A.;Queiroz, A. C. ; Leite, A. B. ; Martins, F.T. ; Doriguetto, A. C. ; Barreiro, E. J. ; Moreira, M. S. A. ; Lima, L. M.  Carbamoyl- N</i> -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.

 

Pedreira, J. G. B.; Nahidino, P.; Kudolo, M.; Pantsar, T.; Berger,B.T. ; Forster, M. ; Knapp, S.; Laufer, S. ; Barreiro, E. J.  Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 alpha MAP Kinase Inhibitors. Journal Of Medicinal Chemistry, v. 63, p. 7347-7354, 2020.

 

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Colodette, N. M.; Franco, L. S.; Maia, Rodolfo C.; Fokoue, H. H.; Sant’anna, C. M. R.; Barreiro, E. J.  Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models. Journal Of Computer-aided Molecular Design, v. 34, p. 1091-1103, 2020.

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Lima, L. M. ; Silva, B. N. M.; Barbosa, G. ; Barreiro, E. J. β-lactam antibiotics: An overview from a medicinal chemistry perspective. European Journal Of Medicinal Chemistry, v. 208, p. 112829, 2020.

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Senger, M. R. ; Evangelista, T. C. S. ; Dantas, R. F. ; Santana, M. V. S. ; Gonçalves, L. C. S.; Neto, L. R.S. ; Ferreira, S. B. ; Junior, F. P.S . COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, v. 115, p. 1, 2020.

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Neto, L.R.S.; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in Chemistry, v. 8, p. 1-18, 2020.

 

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Issy A.C.; Pedrazzi, J. F. C.; Van Oosten, A. B. S.; Checheto, T.; Silva, R. R.; Noel, F.; Del-bel, E.  Effects of doxycycline in Swiss mice predictive models of schizophrenia. Neurotoxicity Research, v. 101007, p. s1264002000268z, 2020.

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Silva, M. M. C.; Alencar, Nogueira, A.K.; Silva, J.S.; Montagnoli, T.L.; Silva, G.F.; Rocha, B.S.; Montes, G.C.; Otero, R.M.; Coelho, P.M.P.; Vasques, J. F.; Trahez, M.M.; Sudo, R.T.; Sudo, G.Z. Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, v. 9, p. 2120, 2020.

 

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Borsoi, M. ; Nunes, L. E. D. ; Barbosa, A. R. ; Lima, M. S. ; Medeiros, I. ; Pranke, M. A. ; Antonio, C. B. ; RATES, S. M. K. ; Neves, G.A.  Intermittent repeated stress but not ketamine changes mice response to antidepressants. Neuroscience Letters, p. 135452, 2020.

 

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Silva, J. C.; Rodrigues, N. C.; Thompson'souza, G. A.; Muniz, V. S.; Neves, J. S.; Figueiredo, R. T.  Mac-1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination. Journal of Leukocyte Biology, v. 107, p. 69-83, 2020. 

 

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Nino, O. M.; Costa, C. S.; Torres, K. M.; Zanol, J. F.; Lima, L. C. F.; Alves, L.M.; Graceli, J. B. High refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats. Toxicology Letters, v. 332, p. 42-55, 2020.

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Graceli, J. B.; Dettogni, R. S.; Merlo, E.; Nino, O. M.; Costa, C. S.; Zanol, J. F.; Morris, E. A. R. ; Alves, L.M. ; Denicol, A. C.  The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Molecular and Cellular Endocrinology, v. 518, p. 110997-111017, 2020.

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Junior, N. C.L.; Camilo, J. F.; Carmo, P. R.; Andrade, M. N.; Braz, B. F.; Santelli, R. E.; Gitirana, L. B.; Ferreira, A. C. F. ; Carvalho, D. P. ; Alves, L.M. ; Dias, G. R. M.  Subacute Exposure to Lead Promotes Disruption in the Thyroid Gland Function in Male and Female Rats. Environmental Pollution, 2020.

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Chagas, A.P.; Peixoto, B.P.; Costa, B.B.; Moreira, T.A.; Cinelli, L.P.; Silva, L.L.; Alves, L.M.; Junior, C.B. Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic. Toxicology Mechanisms and Methods, v. 31, p. 1-34, 2020.
 

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Almeida, J.; Oliveira, V.R.; Avelar, J.L.S.; Moita, B.S.; Lima, L.M. COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química,  2020, 12 (6), 1464-1497.

 

Curnow, A. C.; Gonsalez, S. R.; Gogulamudi, V. R.; Visniauskas, B. ; Simon, E. E. ; Gonzalez, A. A. ; Majid, D. S. A. ; Lara, L.S. ; Prieto, M. C.  Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct. Frontiers in Physiology, v. 11, p. 153, 2020.

 

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Ortiz, M.; Coutinho, D. S.; Ciambarella, B. T.; Souza, E.; Leite, A. P.; Durli, T. L.; Silva, P. M. R.; Bernardi, A.; Sonvico, F.; Pohlmann, A. R.; Martins, M. A.; Guterres, S. S. Intranasal administration of budesonide-loaded nanocapsule-microagglomerates as an innovative strategy for asthma treatment. Drug Delivery and Translational Research, 2020.

 

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Coutinho, D. S.; Pires, J.; Gomes, H.; Pohlmann, A.; Guterres, S.; Silva, P. M. R. E.; Ferrarini, S.; Bernardi, A.; Martins, M.A. Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice. Pharmaceutics, v. 12, p. 1075, 2020.

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Insuela, D. B. R.; Ferrero, M.R.; Coutinho, D. S.; Martins, M. A.; Carvalho, V. F. Could Arachidonic Acid-Derived Pro-Resolving Mediators Be a New Therapeutic Strategy for Asthma Therapy?. Frontiers in Immunology, v. 11, p. 1-9, 2020.

 

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Mello, F.V.C.; Quaresma, B.M.C.S.; Pitombeira, M.C.R.; Brito, M.A.; Farias, P.P.; Castro, S.L.; Salomão, K.; Carvalho, A.S.; Paula, J.I.O.; Nascimento, S.B.; Cupello, M.P.; Paes, M.C; Boechat, N.; Felzenszwalb, Israel . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European Journal of Medicinal Chemistry, v. 186, p. 111887-111902, 2020.


Boechat, N.; Carvalho, R. C.C. ; Ferreira, M.L. G. ; Coutinho, J.P.; Sa, P.M. ; Seito, L. N. ; Rosas, E. C. ; Krettli, A.U. ; Bastos, M. M. ; Pinheiro, L. C.S.  Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. Bioorganic & Medicinal Chemistry, v. 28, p. 115832-115846, 2020.

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Pinheiro, L.C.S.; Hoelz, L.V.B.; Ferreira, M.L.G.; Oliveira, L.G.; Pereira, R.F.A.; Valle, A.M.; André, L.S.P.; Scaffo, J.; Pinheiro, F.R.; Ribeiro, T.A.N.; Sachs, D.; Pascoal, A.C.R.F.; Boechat, N.; Aguiar'alves, F. Synthesis of benzoylthiourea derivatives and analysis of their antibacterial performance against planktonic Staphylococcus aureus and its biofilms. Letters in Applied Microbiology, v. 71, p. 645-651, 2020.

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Souza, A. A. A. ; Torres, L. R. ; Capobianco, L. R. P. L. ; Paula, V. S. ; Cascabulho, C. M. ; Salomao, K. ; Almeida, M. G. B. ; Ferreira, M.L G. ; Boechat, N. ; Pinheiro, L. C. S. ; Souza, E. M.  Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells. Viruses-Basel, v. 13, p. 1-15, 2020.

 

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Martins, D.L.; Borges, A.A.; Silva, N. A.; Faria, J.V.; Hoelz, L.V.B.; Souza, H.V.C.M.; Bello, M.L.; Boechat, N.; Ferreira, V.F.; Faria, R.X. P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones. Bioorganic Chemistry, v. 104, p. 104278-104289, 2020.

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Ferreira, T. P. T.; JG, Lima; Filho, F.F. ; SA, Y. A. P. J. ; AC, Arantes ; Guimaraes, F. V. ; V, Carvalho ; Hogaboam, C M ; J, Wallace ; Martins, M. A. ; Silva, PM . Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Frontiers in Endocrinology, v. 11, p. 388, 2020.

 

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Ventura, R. D. ; Chaves, A. S. ; Magalhaes, N. S. ; Gonzalez, F. B. ; Pacini, M. F. ; Perez, A. R. ; Silva, P. M. R. ; M.A., Martins ; VF, Carvalho . Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. Free Radical Biology and Medicine, v. 156, p. 137-143, 2020.


Nunes, I. K. C.; Souza, E. T.; Martins, I. R. R.; Barbosa, G. ; Junior, M. O. M.; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, Carvalho ; Martins, M. A. ; Lima,L.M . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.

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Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S. ; Silva, E.T. ; Souza, M.V. N.; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A. Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology, v. 11, p. 1159, 2020.

 

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Cavalieri,I.C.P.; Valenca, H. M. ; Moraes, J.A. ; Gitirana, L.B.; Souza, B.R. ; Schmidt, M ; Valença, S.S . Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice. International Journal of Molecular Sciences, v. 21, p. 9658, 2020.

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Nascimento, M.S.S. ; Câmara, V.R.F. ; Costa, J.S. ; Barbosa, J.M.C. ; Lins, A.S.M. ; Salomão, K. ; Castro, S.L.; Carvalho, S.A. ; Silva, E.F. ; Ferreira. E.;  ; Fraga, C.A.M. Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates. Medicinal Chemistry , v. 16, p. 774-783, 2020.

 

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Araujo-montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; Silva-jr, F.P.  Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells. Protein Expression and Purification, v. 167, p. 105532, 2020.

 

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Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical Pharmacology , v. 171, p. 113679, 2020.

 

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Costa, G. ; Montagnoli, T. L. ; Da SILVA, J. S. ; Alencar, A. K. N. ; Gamba, L. E.R. ; Alves, B. E.O. ; Moraes, M. C. ; Trachez, M. M ; Nascimento, J. H.M. ; Coelho, P.M.P. ; Mendez-otero, R. ; Lima, L.M. ; Barreiro, E.J. ; Sudo, Roberto Takashi ;  Sudo, G.Z . New benzofuran N-acylhydrazone reduces cardiovascular dysfunction in obese rats by blocking TNF-alpha synthesis. Drug Design Development and Therapy , v. 14, p. 3337-3350, 2020.

 

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Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Selmi-ruby, S. ; Maximo, V. ; Soares, P. ;  Alves, L. M. Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and Cellular Endocrinology , v. 502, 2020.

 

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Reis, E.M. ; Nobre, C. C. G. ; Chagas, A.P. ;  Alves, L.M. ; Junior, C.B . Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2020.

 

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Lindoso, RS ; Lopes, J.A. ; Binato, R. ; Abdelhay, E. ; Takiya, C.M. ; Miranda, K.R. ; Lara, L. S. ; Viola ,A ; Bussolati, B ; Vieyra, A. ; Collino F . Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection. Molecular Therapy-Methods & Clinical Development, v. 16, p. 63-77, 2020.

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Dick, C. F. ; Guimarães, L.M. ; Kelly, L.F.C. ; Cortes, A.L. ;  Morcillo, L.L.S. ; Sampaio, L.S. ; Fernandes, J. R.M. ; Vieyra, A. . A ferric reductase of Trypanosoma cruzi (TcFR) is involved in iron metabolism in the parasite. Experimental Parasitology, v. 217, p. 107962, 2020.

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Lima, J. A. ; R. Costa, T.W. ; Fonseca, A. C.C. ; Amaral, R. F. ; Nascimento, M.D. S.B. ; Filho, O.A.S. ; Miranda, A.L.P. ; Neto, D.C.F.; Lima, F.R.S. ; Hamerski, L. ; Tinoco, L. W.  Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorganic chemistry, v. 104, p. 104215, 2020.

Nunes, I.C.N. ; Souza, E.T. ; Martins, I.R.M. ; Barbosa, G. ; Junior, M.O.N. ; Medeiros, M.M. ; Silva, S. W.D. ; Balliano, T.L.; Silva, B.A. ; Silva, P.M.R.; Carvalho, V.F. ; Martins, M.A.; Lima, L.M.  Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 204, p. 112492, 2020.

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Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S.; Silva, E.T.; Souza, M.V.N. ; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A . Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology , v. 11, p. 1159, 2020.

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Pinto, D.P. ; Coutinho, D.S. ; Carvalho, K.I.M. ; Ferrero, M. R. ; Silva, L.V. ; Silveira, G.P. E. ; Silva, D. M.; Araújo, J.F.G. ; Silva, A. C.A. ; Pereira, H.M. ; Fonseca, L.B. ; Faria, R.X. ; Souza, M.V.N. ; Silva, E.T.; Filho, O.A.S. ; Costa, J.C. ; Amendoeira, F. C. ; Martins, M.A. Pharmacological profiling of JME-173, a novel mexiletine derivative combining dual anti-inflammatory/anti-spasmodic functions and limited action in Na+ channels. European Journal of Pharmacology. v. 885, p. 173367, 2020.

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Aguiar, R.P.S. ; Peruchetti, D.B. ; Rocco, P.R.M. ; Schmaier, A.H. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, Vinicius de Frias ; Pinheiro, A.A.S. ; Neves, C.C . Role of the renin angiotensin system in the development of severe COVID-19 in hypertensive patients. AJP: Lung Cellular and Molecular Physiology, 2020.

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Frattani, F. S.; Lima, L. M.; Barreiro, E. J.; Zingali, R.B. The antithrombotic and haemostatic effects of LASSBio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats. Journal of Pharmacy and Pharmacology , v. 69, p. 1374-1380, 2017.

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Dias A. F. ; Lara, L. S. ; Filho , H.M. ; Vieyra, A.  Is angiotensin-(3-4) (val-tyr), the shortest angiotensin ii derived peptide, opening new vistas on renin angiotensin system? Journal of The Renin-Angiotensin-Aldosterone System, v. 18, p. 147032031668933, 2017.

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Alves, A.; Assis, A.; Vieira, G. C.; Martins, M. A.; Filho, J. M. B.; Piuvezam, M. RMilonine, an alkaloid of Cissampelos sympodialis eichl. (menispermaceae) inhibits histamine release of activated mast cells. Inflammation , v. 40, p. 1-11, 2017.

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Castro, L. L.; Xisto, D. G.; Kitoko, J. Z.; Cruz, F. F.; Olsen, P. C.; Redondo, P. A. G.; Ferreira, T. P. T.; Weiss, D. J.; Martins, M. A.; Morales, M. M.; Rocco, P. R. M. Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma. Stem Cell Research & Therapy, v. 8, p. 151-162, 2017.

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Kitoko, J. Z.; Castro, L. L.; Nascimento, A. P.; Abreu, S. C.; Cruz, F. F.; Arantes, A. C.; Xisto, D. G.; Martins, M. A.; Morales, M. M.; Rocco, P. R. M.Olsen, P. C.  Therapeutic administration of bone marrow-derived mesenchymal stromal cells reduces airway inflammation without upregulating tregs in experimental asthma. Clinical and Experimental Allergy, v. 0001, p. 14-0015, 2017.

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Guerra, F. S.; Oliveira, R. G.; Fraga, C. A. M.; Mermelstein, C. S.; Fernandes, P.D. Rock inhibition with fasudil induces beta-catenin nuclear translocation and inhibits cell migration of mda-mb 231 human breast cancer cells. Scientific Reports, v. 7, p. 13723, 2017.

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Amorim, J. L.; Figueiredo, J. B.; Amaral, A. C. F.; Barros, E. G. O.; Palmero, C.; Palantinos, M. A.; Ramos, A. S.; Ferreira, J. L. P.; Silva, J. R. A.; Benjamim, C. F.; Basso, S. L.; Nasciutti, L. E.; Fernandes, P. D.  Wound healing properties of Copaifera paupera in diabetic mice. Plos One , v. 12, p. E0187380, 2017.

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Ribeiro, T.; Oliveira, J. T.; Almeida, F. M.; Tomaz, M. A.; Melo, P. A.; Marques, S. A.;  Andrade, G. M.; Martinez, A. M. B . Blockade of atp p2x7 receptor enhances ischiatic nerve regeneration in mice following a crush injury. Brain Research, v. 115, p. 1111-11112, 2017.

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Galvão, I.; Vago, J. P.; Barroso, L. C.; Tavares, L. P.; Junior, C. M. Q.; Costa, V. V.; Carneiro, F. S.; Ferreira, T. P. T.;  Silva, P. M.; Amaral, F. A.; Souza, L. P.; Teixeira, M. M.  Annexin a1 promotes timely resolution of inflammation in murine gout. European Journal of Immunology, v. 47, p. 585-596, 2017.

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Oliveira, L. G.; Testasicca, M. C. S.; Vargo, J. P.; Figueiredo, A. B.; Canavaci, A.; Perucci, L. O.; Ferreira, T. P. T.; Coelho, E. A. F.; Goncalves, D. U.; Rocha, M. O. C.; Silva, P.; M.; Ferreira, C. N.; Junior, C. Q.; Souza, L. P.; Fernandes, A. P. Annexin a1 is involved in the resolution of inflammatory responses during Leishmania braziliensis infection. Journal of Immunology, v. 198, p. 3227-3236, 2017.

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Dalmeida, A. P. L.; Silva, P. M.; Chiambarella, B. T.; Martins, M. A.; Bernardi, A.  Α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International Journal of Nanomedicine, v. 12, p. 4479-4491, 2017.

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Coutinho, D. S.; Valotta, E. A. A.; Nascimento, C. V. M. F.; Pires, A. L. A.; Napimoga, M. H.; Carvalho, V. F.; Torres, R. C.; Silva, P. M. R.; Martins, M.A. 15-deoxy-delta-12,14-prostaglandin j2 inhibits lung inflammation and remodeling in distinct murine models of asthma. Frontiers in Immunology, v. 8, p. 1-12, 2017.

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Ribeiro, E. L.; Fragoso, I. T.; Gomes, F. O. S.; Oliveira, A. C.; Silva, A. K. S.; Silva, P. M.; Ciambarella, B. T.; Ramos, I. P. R.; Peixoto, C. A. Diethylcarbamazine: a potential treatment drug for pulmonary hypertension?. Toxicology and Applied Pharmacology, v. 333, p. 92-99, 2017.

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Costa, P.R.R. Interaction between bioactive compound 11a-n-tosyl-5-deoxi-pterocarpan (lqb-223) and calf thymus DNA: spectroscopic approach, electrophoresis and theoretical studies. International Journal of Biological Macromolecules, v. 96, p. 223-233, 2017.

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Scatena, G.S.; Cassiano, N. M.; Netto, C. D.; Costa, P. R. R.; Cass, Q.B.; Batista, J.M.  Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone lqb-118. Chirality, v. 29, p. 167-171, 2017.

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Costa, P. R. R.; Cívicos, J.; Coimbra, J. Solvent-free synthesis of salen ligands and pd(ii)- and cu(ii)-salen complexes: their use in the oxidation of α-tetralones to α-naphthols. Synthesis-stuttgart, v. 49, p. A-1, 2017.

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Cívicos, J.; Costa, P. R. R.; Domingos, J. Palladium-catalyzed α-arylation of dimethyl malonate and ethyl cyanoacetate with o-alkoxybromobenzenes for the synthesis of phenylacetic acid, esters and phenylacetonitriles. Synopen, v. 01, p. 0091-0096, 2017.

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Ribeiro, V. P.; Melo, A.C.; Feitosa, E. K.; Reis, A. G.; Barroso, M. V.; Cavalieri, I. C.; Carvalho, G. M. C.; Zin, W. A.; Porto, L. C.; Gitirana, L. B.; Lanzetti, M.; Valença, S. S. Atorvastatin and simvastatin promoted mouse lung repair after cigarette smoke-induced emphysema. Inflammation, v. 40, p. 965-979, 2017.

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Cavalieri, I. C.; Reis, A. G.; Feitosa, E. K.; Ribeiro, V. P.; Lanzetti, M.; Gitirana, L. B.; Souza, B. R.; Porto, L. C.; Valença, S. S. Pulmonary emphysema cross-linking with pulmonary fibrosis and vice versa: a non-usual experimental intervention with elastase and bleomycin. Inflammation, v. 40, p. 1487-1496, 2017.

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Nesi, R. T.; Barroso, M. V.; Muniz, V. S.; Arantes, A. C.; Martins, M. A.; Gitirana, L.; Neves, J. S.; Benjamim, C. F.; Lanzetti, M.; Valença, S. S. Pharmacological modulation of reactive oxygen species (ros) improves the airway hyperresponsiveness by shifting the th1 response in allergic inflammation induced by ovalbumin. Free Radical Research, v. 51, p. 708-722, 2017.

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Barroso, M. V.; Cavalieri, I. C. ; Gitirana, L. B.; Fautrel, A. ; Lagente,V. ; Schmidt, M.; Porto, L. C.; Souza, B. R.;  Valença, S. S.; Lanzetti, M. Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of nrf2. Bioorganic & Medicinal Chemistry, v. 25, p. 5557-5568, 2017.

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Silva, C. O.; Costa, A. M. A.; Martins, M. R.; Nascimento, F. V.;  Valença, S. S.; Lagente, V.; Pôrto, L.; Victoni, T . Time course of the phenotype of blood and bone marrow monocytes and macrophages in the lung after cigarette smoke exposure in vivo. International Journal of Molecular Sciences, v. 18, p. 1940, 2017.

 

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Abe, F. S. F. A.; Cunha, R. L. D.; Salomon, P. S.; Júnior, E. R.; Valença, S. S.; Gitirana, L. B. Nanoecotoxicological effects of a sunscreen formulation based on tio2 nanoparticles on microalgae from Guanabara bay (Rio de Janeiro, Brazil). MOJ Polymer Science, v. 1, p. 1-9, 2017.

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Ribeiro, V. M.; Bede, T. P.; Rocha, G.; Barroso, S.; Valença, S. S.; Azeredo, V. B. High-fat diet and high polyphenols beverages effects in enzymatic and non-enzymatic antioxidant activity. Nutricion Hospitalaria, v. 24, p. 169-175, 2017.

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Matias, I.; Diniz, L. P.; Buosi, A. S.; Neves, G.; Stipursky, J.; Gomes, F. C. A. . Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-?1. Frontiers in Aging Neuroscience, v. 9, p. 184, 2017.

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Neves, G.; Borsoi, M.;, ANTONIO, C.; PRANKE, M.A.; BETTI, A. H.;  RATES, M.S.K. Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects. Anais da Academia Brasileira de Ciências, 89(3), 1655-1669. 2017.

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