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2020

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Franco, L.S.; Maia, R.C.; Barreiro, E.J. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (MPRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model. RSC Medicinal Chemistry. 12, 110–119. 

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Doi: 10.1039/d0md00282h

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Silva, N. L. C.; Mota, N. A. V. ; Soares, M. A. ; Araujo, O.M.O.; Espindola, L. C. P. ; Colombo, A. P. V. ; Lopes, R. T. ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.

 

Doi: 10.1111/jre.12730

 

 

Rodrigues, D. A.; Pinheiro, P.S.M. ; Sagrillo, F.S. ; Freitas, M.C.R. ; Alves, M.A, ; Thota, S. ; Tinoco, L.W. ; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-Property Relationship Studies of 3-Acyl-Substituted Furans: The Serendipitous Identification and Characterization of a New Non-Classical Hydrogen Bond Donor Moiety. New Journal of Chemistry, v. 44, p. 10994-11005, 2020.

 

Doi.org/10.1039/D0NJ01598A

 

Rodrigues, D. A ; Pinheiro, P. S. M. ; Sagrillo, F. S. ; Bolognesi, M. L. ; FRAGA, C. A. M. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Medicinal Research Reviews, v. 40, p. 2177-2211, 2020.

 

Doi: 10.1002/med.21701

 

Cunha, T.T.S.; Souza, F. R.; Pinheiro, P. S.M.; Sant’anna, C. M.R.; NOËL, F.; França, T.C. C.; Fraga, C.A.M. Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin. CNS & Neurological Disorders-Drug Targets, v. 19, p. 437-447, 2020.

 

Doi: 10.2174/1871527319999200817153150

 

Viegas, C. ; Fraga, C. A. M.; Sousa, M. E. ; Tarozzi, A . Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?. Frontiers in Pharmacology, v. 11, p. 609274, 2020.

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Doi:10.3389/fphar.2020.609274

 

Thorstenberg, M. L. ; Martins, M. D. A. ; Figliuolo, V. ; Silva, C.L. M ; Savio, L.E. ; Silva, R.C . P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion. Mediators of Inflammation, v. 2020, p. 1-11, 2020.

 

Doi: 10.1155/2020/2545682

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Oliveira, N.F.; Silva, C.L.M. Unveiling the potential of purinergic signaling in schistosomiasis treatment. Current Topics in Medicinal Chemistry, v. 20, p. 1, 2020.

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Doi: 10.2174/1568026620666200924115113

 

Teixeira, R. G. S.; Pascual, R.; Araújo, K.G.L.; Brito, M. A. ; RIOS, C. ; C., A. F. ; Gandía, L. ; Silva, C. L. M. ; Machado, T. B. ; Santos, Wilson,C. In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone. Natural Product Research. V. 1, p. 1-6, 2020.

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Doi: 10.1080/14786419.2020.1739675

 

Pauli, F. P.; Martins, J. R.; Paschoalin, T. ; Ionta, M. ; Barbosa, M. L. C. ; Barreiro, E. J.  Novel VEGFR-2 inhibitors with an N</i> -acylhydrazone scaffold. Archiv Der Pharmazie, v. 276, p. e2000130., 2020.

 

Alves, M. A.;Queiroz, A. C. ; Leite, A. B. ; Martins, F.T. ; Doriguetto, A. C. ; Barreiro, E. J. ; Moreira, M. S. A. ; Lima, L. M.  Carbamoyl- N</i> -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.

 

Pedreira, J. G. B.; Nahidino, P.; Kudolo, M.; Pantsar, T.; Berger,B.T. ; Forster, M. ; Knapp, S.; Laufer, S. ; Barreiro, E. J.  Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 alpha MAP Kinase Inhibitors. Journal Of Medicinal Chemistry, v. 63, p. 7347-7354, 2020.

 

Doi:10.1021/acs.jmedchem.0c00508

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Colodette, N. M.; Franco, L. S.; Maia, Rodolfo C.; Fokoue, H. H.; Sant’anna, C. M. R.; Barreiro, E. J.  Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models. Journal Of Computer-aided Molecular Design, v. 34, p. 1091-1103, 2020.

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Doi:10.1007/s10822-020-00327-9

 

Lima, L. M. ; Silva, B. N. M.; Barbosa, G. ; Barreiro, E. J. β-lactam antibiotics: An overview from a medicinal chemistry perspective. European Journal Of Medicinal Chemistry, v. 208, p. 112829, 2020.

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Doi:10.1016/j.ejmech.2020.112829

 

Senger, M. R. ; Evangelista, T. C. S. ; Dantas, R. F. ; Santana, M. V. S. ; Gonçalves, L. C. S.; Neto, L. R.S. ; Ferreira, S. B. ; Junior, F. P.S . COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, v. 115, p. 1, 2020.

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Doi.org/10.1590/0074-02760200254 

Neto, L.R.S.; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in Chemistry, v. 8, p. 1-18, 2020.

 

Doi.org/10.3389/fchem.2020.00093

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Issy A.C.; Pedrazzi, J. F. C.; Van Oosten, A. B. S.; Checheto, T.; Silva, R. R.; Noel, F.; Del-bel, E.  Effects of doxycycline in Swiss mice predictive models of schizophrenia. Neurotoxicity Research, v. 101007, p. s1264002000268z, 2020.

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Doi: 10.1007/s12640-020-00268-z

 

Silva, M. M. C.; Alencar, Nogueira, A.K.; Silva, J.S.; Montagnoli, T.L.; Silva, G.F.; Rocha, B.S.; Montes, G.C.; Otero, R.M.; Coelho, P.M.P.; Vasques, J. F.; Trahez, M.M.; Sudo, R.T.; Sudo, G.Z. Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, v. 9, p. 2120, 2020.

 

Doi: 10.3390/cells9092120.

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Borsoi, M. ; Nunes, L. E. D. ; Barbosa, A. R. ; Lima, M. S. ; Medeiros, I. ; Pranke, M. A. ; Antonio, C. B. ; RATES, S. M. K. ; Neves, G.A.  Intermittent repeated stress but not ketamine changes mice response to antidepressants. Neuroscience Letters, p. 135452, 2020.

 

Doi: 10.1016/j.neulet.2020.135452

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Silva, J. C.; Rodrigues, N. C.; Thompson'souza, G. A.; Muniz, V. S.; Neves, J. S.; Figueiredo, R. T.  Mac-1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination. Journal of Leukocyte Biology, v. 107, p. 69-83, 2020. 

 

Doi: 10.1002/JLB.4A0119-009RR

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Nino, O. M.; Costa, C. S.; Torres, K. M.; Zanol, J. F.; Lima, L. C. F.; Alves, L.M.; Graceli, J. B. High refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats. Toxicology Letters, v. 332, p. 42-55, 2020.

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Doi.org/10.1016/j.toxlet.2020.07.002

 

Graceli, J. B.; Dettogni, R. S.; Merlo, E.; Nino, O. M.; Costa, C. S.; Zanol, J. F.; Morris, E. A. R. ; Alves, L.M. ; Denicol, A. C.  The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Molecular and Cellular Endocrinology, v. 518, p. 110997-111017, 2020.

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Doi.org/10.1016/j.mce.2020.110997

 

Junior, N. C.L.; Camilo, J. F.; Carmo, P. R.; Andrade, M. N.; Braz, B. F.; Santelli, R. E.; Gitirana, L. B.; Ferreira, A. C. F. ; Carvalho, D. P. ; Alves, L.M. ; Dias, G. R. M.  Subacute Exposure to Lead Promotes Disruption in the Thyroid Gland Function in Male and Female Rats. Environmental Pollution, 2020.

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Doi:10.1016/j.envpol.2020.115889

 

Chagas, A.P.; Peixoto, B.P.; Costa, B.B.; Moreira, T.A.; Cinelli, L.P.; Silva, L.L.; Alves, L.M.; Junior, C.B. Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic. Toxicology Mechanisms and Methods, v. 31, p. 1-34, 2020.
 

Doi:10.1080/15376516.2020.1836102

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Almeida, J.; Oliveira, V.R.; Avelar, J.L.S.; Moita, B.S.; Lima, L.M. COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química,  2020, 12 (6), 1464-1497.

 

Curnow, A. C.; Gonsalez, S. R.; Gogulamudi, V. R.; Visniauskas, B. ; Simon, E. E. ; Gonzalez, A. A. ; Majid, D. S. A. ; Lara, L.S. ; Prieto, M. C.  Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct. Frontiers in Physiology, v. 11, p. 153, 2020.

 

Doi.org/10.3389/fphys.2020.559341

 

Ortiz, M.; Coutinho, D. S.; Ciambarella, B. T.; Souza, E.; Leite, A. P.; Durli, T. L.; Silva, P. M. R.; Bernardi, A.; Sonvico, F.; Pohlmann, A. R.; Martins, M. A.; Guterres, S. S. Intranasal administration of budesonide-loaded nanocapsule-microagglomerates as an innovative strategy for asthma treatment. Drug Delivery and Translational Research, 2020.

 

Doi.org/10.1007/s13346-020-00813-5

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Coutinho, D. S.; Pires, J.; Gomes, H.; Pohlmann, A.; Guterres, S.; Silva, P. M. R. E.; Ferrarini, S.; Bernardi, A.; Martins, M.A. Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice. Pharmaceutics, v. 12, p. 1075, 2020.

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Doi: 10.3390/pharmaceutics12111075.

 

Insuela, D. B. R.; Ferrero, M.R.; Coutinho, D. S.; Martins, M. A.; Carvalho, V. F. Could Arachidonic Acid-Derived Pro-Resolving Mediators Be a New Therapeutic Strategy for Asthma Therapy?. Frontiers in Immunology, v. 11, p. 1-9, 2020.

 

Doi:10.3389/fimmu.2020.580598

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Mello, F.V.C.; Quaresma, B.M.C.S.; Pitombeira, M.C.R.; Brito, M.A.; Farias, P.P.; Castro, S.L.; Salomão, K.; Carvalho, A.S.; Paula, J.I.O.; Nascimento, S.B.; Cupello, M.P.; Paes, M.C; Boechat, N.; Felzenszwalb, Israel . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European Journal of Medicinal Chemistry, v. 186, p. 111887-111902, 2020.

Boechat, N.; Carvalho, R. C.C. ; Ferreira, M.L. G. ; Coutinho, J.P.; Sa, P.M. ; Seito, L. N. ; Rosas, E. C. ; Krettli, A.U. ; Bastos, M. M. ; Pinheiro, L. C.S.  Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. Bioorganic & Medicinal Chemistry, v. 28, p. 115832-115846, 2020.

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Doi: 10.1016/j.bmc.2020.115832.

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Pinheiro, L.C.S.; Hoelz, L.V.B.; Ferreira, M.L.G.; Oliveira, L.G.; Pereira, R.F.A.; Valle, A.M.; André, L.S.P.; Scaffo, J.; Pinheiro, F.R.; Ribeiro, T.A.N.; Sachs, D.; Pascoal, A.C.R.F.; Boechat, N.; Aguiar'alves, F. Synthesis of benzoylthiourea derivatives and analysis of their antibacterial performance against planktonic Staphylococcus aureus and its biofilms. Letters in Applied Microbiology, v. 71, p. 645-651, 2020.

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Doi.org/10.1111/lam.13359

Souza, A. A. A. ; Torres, L. R. ; Capobianco, L. R. P. L. ; Paula, V. S. ; Cascabulho, C. M. ; Salomao, K. ; Almeida, M. G. B. ; Ferreira, M.L G. ; Boechat, N. ; Pinheiro, L. C. S. ; Souza, E. M.  Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells. Viruses-Basel, v. 13, p. 1-15, 2020.

 

Doi: 10.3390/v13010036.

Martins, D.L.; Borges, A.A.; Silva, N. A.; Faria, J.V.; Hoelz, L.V.B.; Souza, H.V.C.M.; Bello, M.L.; Boechat, N.; Ferreira, V.F.; Faria, R.X. P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones. Bioorganic Chemistry, v. 104, p. 104278-104289, 2020.

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Doi: 10.1016/j.bioorg.2020.104278.

Ferreira, T. P. T.; JG, Lima; Filho, F.F. ; SA, Y. A. P. J. ; AC, Arantes ; Guimaraes, F. V. ; V, Carvalho ; Hogaboam, C M ; J, Wallace ; Martins, M. A. ; Silva, PM . Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Frontiers in Endocrinology, v. 11, p. 388, 2020.

 

Doi:10.3389/fendo.2020.00388

Ventura, R. D. ; Chaves, A. S. ; Magalhaes, N. S. ; Gonzalez, F. B. ; Pacini, M. F. ; Perez, A. R. ; Silva, P. M. R. ; M.A., Martins ; VF, Carvalho . Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. Free Radical Biology and Medicine, v. 156, p. 137-143, 2020.

Nunes, I. K. C.; Souza, E. T.; Martins, I. R. R.; Barbosa, G. ; Junior, M. O. M.; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, Carvalho ; Martins, M. A. ; Lima,L.M . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.

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Doi: 10.1016/j.ejmech.2020.112492. 

Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S. ; Silva, E.T. ; Souza, M.V. N.; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A. Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology, v. 11, p. 1159, 2020.

 

Doi.org/10.3389/fphar.2020.01159

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Cavalieri,I.C.P.; Valenca, H. M. ; Moraes, J.A. ; Gitirana, L.B.; Souza, B.R. ; Schmidt, M ; Valença, S.S . Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice. International Journal of Molecular Sciences, v. 21, p. 9658, 2020.

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Doi: 10.3390/ijms21249658.

 

Nascimento, M.S.S. ; Câmara, V.R.F. ; Costa, J.S. ; Barbosa, J.M.C. ; Lins, A.S.M. ; Salomão, K. ; Castro, S.L.; Carvalho, S.A. ; Silva, E.F. ; Ferreira. E.;  ; Fraga, C.A.M. Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates. Medicinal Chemistry , v. 16, p. 774-783, 2020.

 

Doi:10.2174/1573406415666190627103013

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Araujo-montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; Silva-jr, F.P.  Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells. Protein Expression and Purification, v. 167, p. 105532, 2020.

 

Doi:10.1016/j.pep.2019.105532

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Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical Pharmacology , v. 171, p. 113679, 2020.

 

Doi: 10.1016/j.bcp.2019.113679

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Costa, G. ; Montagnoli, T. L. ; Da SILVA, J. S. ; Alencar, A. K. N. ; Gamba, L. E.R. ; Alves, B. E.O. ; Moraes, M. C. ; Trachez, M. M ; Nascimento, J. H.M. ; Coelho, P.M.P. ; Mendez-otero, R. ; Lima, L.M. ; Barreiro, E.J. ; Sudo, Roberto Takashi ;  Sudo, G.Z . New benzofuran N-acylhydrazone reduces cardiovascular dysfunction in obese rats by blocking TNF-alpha synthesis. Drug Design Development and Therapy , v. 14, p. 3337-3350, 2020.

 

Doi: 10.2147/DDDT.S258459

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Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Selmi-ruby, S. ; Maximo, V. ; Soares, P. ;  Alves, L. M. Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and Cellular Endocrinology , v. 502, 2020.

 

Doi: 10.1016/j.mce.2019.110677

 

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Reis, E.M. ; Nobre, C. C. G. ; Chagas, A.P. ;  Alves, L.M. ; Junior, C.B . Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2020.

 

Doi: 10.23937/2469-5696/1410048

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Lindoso, RS ; Lopes, J.A. ; Binato, R. ; Abdelhay, E. ; Takiya, C.M. ; Miranda, K.R. ; Lara, L. S. ; Viola ,A ; Bussolati, B ; Vieyra, A. ; Collino F . Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection. Molecular Therapy-Methods & Clinical Development, v. 16, p. 63-77, 2020.

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Doi:10.1016/j.omtm.2019.11.002

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Dick, C. F. ; Guimarães, L.M. ; Kelly, L.F.C. ; Cortes, A.L. ;  Morcillo, L.L.S. ; Sampaio, L.S. ; Fernandes, J. R.M. ; Vieyra, A. . A ferric reductase of Trypanosoma cruzi (TcFR) is involved in iron metabolism in the parasite. Experimental Parasitology, v. 217, p. 107962, 2020.

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Doi:10.1016/j.exppara.2020.107962

 

Lima, J. A. ; R. Costa, T.W. ; Fonseca, A. C.C. ; Amaral, R. F. ; Nascimento, M.D. S.B. ; Filho, O.A.S. ; Miranda, A.L.P. ; Neto, D.C.F.; Lima, F.R.S. ; Hamerski, L. ; Tinoco, L. W.  Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorganic chemistry, v. 104, p. 104215, 2020.

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Nunes, I.C.N. ; Souza, E.T. ; Martins, I.R.M. ; Barbosa, G. ; Junior, M.O.N. ; Medeiros, M.M. ; Silva, S. W.D. ; Balliano, T.L.; Silva, B.A. ; Silva, P.M.R.; Carvalho, V.F. ; Martins, M.A.; Lima, L.M.  Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 204, p. 112492, 2020.

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DOI: 10.1016/j.ejmech.2020.112492

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Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S.; Silva, E.T.; Souza, M.V.N. ; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A . Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology , v. 11, p. 1159, 2020.

​

Doi.: 10.3389/fphar.2020.01159

​

Pinto, D.P. ; Coutinho, D.S. ; Carvalho, K.I.M. ; Ferrero, M. R. ; Silva, L.V. ; Silveira, G.P. E. ; Silva, D. M.; Araújo, J.F.G. ; Silva, A. C.A. ; Pereira, H.M. ; Fonseca, L.B. ; Faria, R.X. ; Souza, M.V.N. ; Silva, E.T.; Filho, O.A.S. ; Costa, J.C. ; Amendoeira, F. C. ; Martins, M.A. Pharmacological profiling of JME-173, a novel mexiletine derivative combining dual anti-inflammatory/anti-spasmodic functions and limited action in Na+ channels. European Journal of Pharmacology. v. 885, p. 173367, 2020.

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Doi:10.1016/j.ejphar.2020.173367

 

Aguiar, R.P.S. ; Peruchetti, D.B. ; Rocco, P.R.M. ; Schmaier, A.H. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, Vinicius de Frias ; Pinheiro, A.A.S. ; Neves, C.C . Role of the renin angiotensin system in the development of severe COVID-19 in hypertensive patients. AJP: Lung Cellular and Molecular Physiology, 2020.

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Doi:10.1152/ajplung.00286.2020

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Mattos, M. S. ; Ferrero, M. R. ; Kraemer, L. ; Lopes, G. A. ; Reis, D. C. ; Oliveira, F. M. ; Cassali, G. D. ; Brandolini, L. ; Allegretti, M. ; Garcia, C. C. ; Martins, M.A. ; Teixeira, M. M. ; Russo, R. C. CXCR1 and CXCR2 inhibition by Ladarixin improves neutrophil-dependent airway inflammation in mice. Frontiers in Immunology ,  2020.

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Silva, M.F. ; Lima, E.T. ; Pruccoli, Letizia ; Castro, N. ; Guimarães, M. ; Silva, F. ; Nadur, N.F. ; Azevedo, L. ; Kümmerle, A. ; Guedes, I.; Dardenne, L. ; Gontijo, V. ; Tarozzi, A. ; Viegas, C. Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer?s Disease. Molecules, v. 25, p. 3165, 2020.

 

Doi: 10.3390/molecules25143165

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Prado, V.M. ; Queiroz, T.B.; Sá, P. M. ; Seiceira, R.C. ; Boechat, N. ; Ferreira, F.F . Mechanochemistry for the production of a hybrid salt used in the treatment of malaria. Green Chemistry, v. 22, p. 51-61, 2020.

 

Doi:10.1039/C9GC02478F

 

Rogerio, K.R. ; Graebin, C.S. ; Domingues, L.H.P. ; Oliveira, L.S. ; Silva, V.S.F.; Ribeiro, C.T.D. ; Carvalho, L. J.M. ; Boechat, N. Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum. Current topics in Medicinal Chemistry, v. 20, p. 99-110, 2020.

 

Doi: 10.2174/1568026619666191019100711

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Nunes, I. K. C. ; Souza, E. T. ; Martins, I. R. R. ; Barbosa, G. ; Junior, M. O.M ; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, C. ; Martins, M. A. ; LM, Lima . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.

 

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2017

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Alencar, A.K.N. ; Silva, J.S. ; Lin, M. ; Silva. A.M.S. ; Sun, X. ; Ferrario, C. M. ; Cheng, C. ; Sudo, R.T. ; Sudo, G.Z. ; Wang, H. ; Groban, l.  Effect of age, estrogen status, and late-life gper activation on cardiac structure and function in the fischer344×brown norway female rat. The journals of gerontology. Series a, biological sciences and medical sciences , v. 72, p. 152-162, 2017.

 

Camargo, G.A.C.D. ; Silva, N.L.C. ; Miranda, A.L.P. ; Tributino, J.L.M. ; Colombo, N.H. ; Duque, C. . Periodontopathogens, candida spp. And immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis. Brazilian journal of oral sciences, v. 15, p. 226-233, 2017.

 

Doi: 10.20396/bjos.v15i3.8649993

Silva, R. V. ; Oliveira, J. T ; Santos, . L. R ; Dias, F C ; Martinez, A M B ;Lima, C.F.K.  ; Miranda, A.L.P . Long-chain omega-3 fatty acids supplementation accelerates nerve regeneration and prevents neuropathic pain behavior in mice. Frontiers in pharmacology, v. 8, p. 723, 2017.

 

Doi: 10.3389/fphar.2017.00723

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Betti,A.H.. ; Antonio,C.B.  ; Pompeu,T.E.T. ; Martins, T.S. ; Herzfeldt, V. ; Stolz, E.D. ; Fraga, C.A.M. ; Barreiro, E.J. ; Noël, F. ; Rates, S.M.K. Lassbio-1422. Behavioural pharmacology , v. 28, p. 48-62, 2017.

 

Silva,J.; Costa, D.G. ; Sudo, R.; Wang, H. ; Groban, L. ; Ferraz, E. ; Nascimento,J. ; Fraga,C.A.M. ; Barreiro, E.J. ; Sudo, G.Z. Adenosine a2a  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction. Drug design, development and therapy , v. Volume11, p. 553-562, 2017.

 

Doi: 10.2147/dddt.s113289

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Carvalho, S.A. ; Osorio, L.F.B. ; Salomão,K. ; Castro, S.L. ; Wardell, S.M. S. V. ; Wardell, J.L. ; Silva, E.F. ; Fraga, C.A.M . Design, synthesis, and trypanocidal activity of novel 5-nitroimidazolyl -benzyloxime ethers. Journal of heterocyclic chemistry , v. 54, p. 3626-3631, 2017.

 

Doi: 10.1002/jhet.2989

Carvalho, V.F. ; Ferreira, T.P.T. ; Arantes, A.C. S. ; Noël, F. ; Tesch, R. ; Sant’anna, C. M. R. ; Barreiro, E.J. L. ; Fraga, C.A.M. ;Silva, P.M.R. ; Martins, M.A.Lassbio-897 reduces lung injury induced by silica particles in mice: potential interaction with the a2a receptor. Frontiers in pharmacology , v. 8, p. 1, 2017.

 

Doi: 10.3389/fphar.2017.00778

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Savio, l. E. ; Mello, P. ; Figliuolo, V. ; Almeida, T. ; Santana, P. ; Oliveira,S.D.S. ; Silva, C.L.M. ; Fedbrugge, l. ; Csizmadia, E. ; Minshall, R. ; Longhi, M. S. ; Wu, Y. ; Simon, R. ; Silva,R.C. Cd39 limits p2x7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. Journal of hepatology , v. 67, p. 1, 2017.

 

Doi:10.1016/j.jhep.2017.05.021

 

Cardoso, T. C. ; Pompeu, T. E. ; Silva, C.L.M . The p2y1 receptor-mediated leukocyte adhesion to endothelial cells is inhibited by melatonin. Purinergic signalling , p. 1, 2017.

 

Doi:10.1007/s11302-017-9565-4

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Ibiapino, A.L. ; Figueiredo, L.P. ; Lima, L.M. ; Barreiro, E.J.. ; Punzo,F. ; Ferreira, F.F. Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents. New journal of chemistry , v. 41, p. 000-000, 2017.

 

Doi:10.1039/C7NJ00074J

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Figueiredo, L.P. ; Ibiapino, A.L. ; Amaral, D.N. ; Ferraz, L.S. ; Rodrigues, T ; Barreiro, E.J. ; Lima, L.M. ; Ferreira, F.F. Structural characterization and cytotoxicity studies of different forms of a combretastatin a4 analogue. Journal of molecular structure , v. 1147, p. 226-234, 2017.

 

Doi:10.1016/j.molstruc.2017.06.093

 

Bastos, I.T.S. ; Costa, F.N. ; Silva, T.F. ; Barreiro, E.J. ; Lima, L.M. ; Braz, Delson ; Lombardo, G.M. ; Punzo, F. ; Ferreira, F.F. ; Barroso, R.C. A combined experimental and in silico characterization to highlight additional structural features and properties of a potentially new drug. Journal of molecular structure , v. 1146, p. 735-743, 2017.

 

Doi:10.1016/j.molstruc.2017.06.061

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Amaral, D. ; Alves, F.S. ; Barreiro, E.J. ; Laufer, S. ; Lima,L.M . Multi-gram preparation of 7-nitroquinoxalin-2-amine. Journal of the brazilian chemical society , v. 28, p. 1874-1878, 2017.

 

Doi:10.21577/0103-5053.20170018 

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Alencar, A.K.N. ; Montes, G.C. ; Barreiro, E.J. ; Sudo, R.T. ; Sudo, G.Z. Adenosine receptors as drug targets for treatment of pulmonary arterial hypertension. Frontiers in pharmacology , v. 8, p. 858, 2017.

 

Doi:10.3389/fphar.2017.00858

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Sodero, A. C. R. ; Vieira, B.A. ; Torres, P.H.M.; Pascutti, P. G. ; Garcia, C. R. S. ; Ferreira, V. F. ; Rocha,D.R. ; Ferreira, S. B. ; Júnior, F.P.S . Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling. Memórias do instituto oswaldo cruz , v. 112, p. 299-308, 2017.

 

Doi:10.1590/0074-02760160417

 

Gasparotto, J. ; Kunzler, A. ; Senger, M. R. ; Souza, C.S.F. ; Simone, S.G. ; Bortolin, R.C.; Somensi, N. ; Pizzol, F.D. ; Moreira, J.C.F. ; Silva, A. L.A. ; Calabrese, K.S. ; Junior, F.P.S. ; Gelain, D.P . N-acetyl-cysteine inhibits liver oxidative stress markers in balb/c mice infected with leishmania amazonensis. Memórias do instituto oswaldo cruz (online) , v. 112, p. 146-154, 2017.

 

Doi:10.1590/0074-02760160403

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Azevedo, L.D. ; Bastos, M.M. ; Vasconcelos, F.C. ; Hoelz, L.V. B. ; Junior, F.P. S. ; Dantas, R.F. ; Almeida, A.C. M. ; Oliveira, A.P. ; Gomes, L.C. ; Maia, R.C. ; Boechat,N. Imatinib derivatives as inhibitors of k562 cells in chronic myeloid leukemia. Medicinal chemistry research , p. 1-13, 2017.

 

Doi: 10.1007/s00044-017-1993-8

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Godinho, A. N. ; Costa, G. T. ; Oliveira, N. O. ; Cardi, B. A. ; Uchoa, D. E. ; Silveira, E. R. ; Quintas, L. E. M. ; Noël, F.G. ; Carvalho, K. M. ; Fonteles, M. C. ; Santos, C. F. ; Lessa, L. M. A. ; Nascimento, N. R. F.  Effects of cardiotonic steroids on isolated perfused kidney and nhe3 activity in renal proximal tubules. Biochimica et biophysica acta-general subjects , v. 1861, p. 1943-1950, 2017.

 

Doi: 10.1016/j.bbagen.2017.05.012

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Souza, G.A.T. ; Gropillo, I. ; Neves, J.S. . Cysteinyl leukotrienes in eosinophil biology: functional roles and therapeutic perspectives in eosinophilic disorders. Frontiers in medicine, v. 4, p. 106, 2017.

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Sena, G. C. ; Merlo, E. ; podratz, P. L. ; Araujo, J. F. ; Lima, L.F.C. ; Brandao, P. A. ; Carneiro, M. T. ; Zicker, M. C. ; Ferreira, A. V.M. ; Takiya, C. M. ; Silva, A. P.S. ; Alves, L.M.; Silva, I. V. ; Graceli, J. B.  Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats. Toxicology and applied pharmacology , v. 319, p. 22-38, 2017.

 

Doi:10.1016/j.taap.2017.01.021

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Pópulo, H. ; Nunes, B ; Sampaio, C. ; Batista, R. ; Pinto, M.T. ; Gaspar, T.B. ; Alves, L.M. ; Cai, R. ; Zhang, X.Y. ; Schally, A.V. ; Simões, M.S. ; Soares, Paula . Inhibitory effects of antagonists of growth hormone-releasing hormone (ghrh) in thyroid cancer. Hormones & cancer , v. 8, p. 314-324, 2017.

 

Doi:10.1007/s12672-017-0307-4

 

Silva, A.P.S. ; Andrade, M.N. ; Rodrigues,P.P. ; Melo, F.D.P. ; Soares, P. ; Graceli, J.B. ; Dias, G.R.M. ; Ferreira, A.C.F. ; Carvalho, D.P. ; Alves, L.M.  Frontiers in endocrine disruption: impacts of organotin on the hypothalamus-pituitary-thyroid axis. Molecular and cellular endocrinology , v. 460, p. 246-257, 2017.

 

Doi:10.1016/j.mce.2017.07.038

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Frattani, F.S. ; Lima, L.M. ; Barreiro, E.J. ; Zingali, R.B. The antithrombotic and haemostatic effects of lassbio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats. Journal of pharmacy and pharmacology , v. 69, p. 1374-1380, 2017.

 

Doi: 10.1111/jphp.12771

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Moraes, B.S. ; Azeredo, F.J. ; Izoton, J.C. ; Amaral, M.; Barreiro,E.J.; Freddo, R.J. ; Costa, T.D. ; Lima,L.M.; Haas, S.E. Leishmanicidal candidate lassbio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution. Xenobiotica , v. 21, p. 1-32, 2017.

 

Doi: 10.1080/00498254.2017.1405465

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Dias ; A. F. ; Lara, L. S. ; Filho , H.M. ; Vieyra, A.  Is angiotensin-(3-4) (val-tyr), the shortest angiotensin ii derived peptide, opening new vistas on renin angiotensin system?. Jraas. Journal of the renin-angiotensin-aldosterone system , v. 18, p. 147032031668933, 2017.

 

Doi: 10.1177/1470320316689338

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Lara, L. S.; Bourgeois, C. ; El-dahr, S. ; Prieto, M.C . Bradykinin/b receptor activation regulates renin in m 1 cells via protein kinase c and nitric oxide. Physiological reports, v. 5, p. E13211, 2017.

 

Doi: 10.14814/phy2.13211

 

Mendes , L.V.P. ; Gonsalez , S.R. ; Pinto, L.M.O. ; Acacio, A. P. ; Takya, C.M. ; Nascimento, J.H.M. ; Lamas, M.E. ; Vieyra, A. ; Cunha, V.M.N.; Lara, L. S.  Long-term effect of a chronic low-protein multideficient diet on the heart: hypertension and heart failure in chronically malnourished young adult rats. International journal of cardiology , p. 31864, 2017.

 

Doi: 10.1016/j.ijcard.2017.03.110

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Ferrão, F.M. ; Cardoso, L.H.D. ; Drummond, H.A. ; Li, X.C. ; Zhuo, J.L. ; Gomes, D.S. ; Lara, L.S. ; Vieyra, A. ; Lowe,J.  Luminal angiotensin ii is internalized as a complex with at r/at r heterodimers to target endoplasmic reticulum in llc-pk cells. American journal of physiology-renal physiology , v. 3, p. Ajprenal.00261.2016, 2017.

 

Doi: 10.1152/ajprenal.00261.2016

 

Gonzalez, A.A. ; Lara, L.S. ; Prieto, M.C.  Role of collecting duct renin in the pathogenesis of hypertension. Current hypertension reports , v. 19, p. 62, 2017.

 

Doi: 10.1007/s11906-017-0763-9

 

Sampaio, L.S. ; Silva, P.A. ; Ribeiro, V.S. ; Chaves, C.C. ; Lara, L.S. ; Vieyra, A. ; Lamas, M.E. Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?. Lipids in health and disease , v. 16, p. 245, 2017.

 

Doi: 10.1186/s12944-017-0634-z

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Rodrigues, A. ; Guimarães, D. ; Konno, T. ; Tinoco, L.W. ; Barth, T. ; Aguiar, F. ; Lopes, N. ; Leal,I. ; Raimundo, J. ; Muzitano, M . Phytochemical study of tapirira guianensis leaves guided by vasodilatory and antioxidant activities. Molecules (basel. Online) , v. 22, p. 304, 2017.

 

Doi: 10.3390/molecules22020304

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Griffith, C.M. ; Williams, P.B. ; Tinoco, L.W. ; Dinges, M.M. ; Wang, Y. ; Larive, C.K.  1 h nmr metabolic profiling of earthworm ( eisenia fetida ) coelomic fluid, coelomocytes, and tissue: identification of a new metabolite-malylglutamate. Journal of proteome research , v. 16, p. 3407-3418, 2017.

 

Doi: 10.1021/acs.jproteome.7b00439

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Prevatto, J.P. ; Torres, R.C. ; Diaz, B.L. ; Silva, P.M. R. E ; Martins, M.A. ; Carvalho, V.F . Antioxidant treatment induces hyperactivation of the hpa axis by upregulating acth receptor in the adrenal and downregulating glucocorticoid receptors in the pituitary. Oxidative medicine and cellular longevity , v. 2017, p. 1-10, 2017.

 

Doi:10.1155/2017/4156361

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Alves, A. ; Assis, A. ; Vieira, G.C. ; Martins, M.A. ; Filho, J.M.B. ; Piuvezam, M.R . Milonine, an alkaloid of cissampelos sympodialis eichl. (menispermaceae) inhibits histamine release of activated mast cells. Inflammation , v. 40, p. 1-11, 2017.

 

Doi:10.1007/s10753-017-0652-z

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Castro, L.L. ; Xisto, D.G. ; Kitoko, J.Z. ; Cruz, F.F. ; Olsen, P.C. ; Redondo, P.A.G.; Ferreira, T.P.T. ; Weiss, D.J. ; Martins, M.A. ; Morales, M.M. ; Rocco, P.R.M . Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma. Stem cell research & therapy , v. 8, p. 151-162, 2017.

 

Doi: 10.1186/s13287-017-0600-8

 

Kitoko, J.Z. ; Castro, L.L. ; Nascimento, A.P. ; Abreu, S.C. ; Cruz, F.F. ; Arantes, A.C. ; Xisto, D.G. ; Martins, M.A. ; Morales, M.M. ; Rocco, P.R.M. ; Olsen, P.C.  Therapeutic administration of bone marrow-derived mesenchymal stromal cells reduces airway inflammation without upregulating tregs in experimental asthma. Clinical and experimental allergy , v. 0001, p. 14-0015, 2017.

 

Doi: 10.1111/cea.13048

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Socodato, R. E. S. ; Santiago, F. N. ; Portugal, C. C. ; Domith, I. ; Encarnacao, T. G. ;Loiola, E. C. ; Ventura, A. L. M. ; Cossenza, M. ; Relvas, J. B. ; Castro, N. G. ; Carvalho, R.P. Dopamine promotes nmda receptor hypofunction in the retina through d1 receptor-mediated csk activation, src inhibition and decrease of glun2b phosphorylation. Scientific reports, v. 7, p. 40912, 2017.

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Doi:10.1038/srep40912

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Azeredo, L.F.S.P; Coutinho, J.P. ; Jabor, V.A.P. ; Feliciano, P. R. ; Nonato, M. C. ; Kaiser, C.R. ; Menezes, C. M. R. ; Hammes, A. S. O. ; Caffarena, E. R. ; Hoelz, L.V.B. ; Souza, N. B. ; Pereira, G. A. N. ; Ceravolo, I. P. ; Krettli, A.U. ; Boechat, N.  Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-plasmodium falciparum, antimalarial, and pf-dihydroorotate dehydrogenase inhibitors. European journal of medicinal chemistry, v. 126, p. 72-83, 2017.

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Doi: 10.1016/j.ejmech.2016.09.073

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Sacramento, C.Q.M.; Freitas, C.S.G. Rocha, N.H.; Miranda,L.V.B.; Rodrigues,M.F.; Marttorelli,N.; Ferreira,A. Lima,A.C.B. Abrantes,G.; Vieira, J.L. ; Bastos,Y.R.; Volotão,M.M.M.; Nunes,E.; Tschoeke,E.P.; Leomil, D.A.;  loiola,L.; Trindade,E.C.; Rehen,P.; Bozza, S.K.; Bozza, F.A.; Patrícia T. Boechat, N.T.;, Filippis, A.M.B.F.L. The clinically approved antiviral drug sofosbuvir inhibits zika virus replication. Scientific reports , v. 7, p. 40920, 2017.

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Doi: 10.1038/srep40920.

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Boechat, N.; Branco, F. S. C. ; França, R.R.F. ; Domingos, J.L. ; Menozzi, C.A.C . Optimization of fluconazol synthesis: an important azole antifungal drug. Revista virtual de química, v. 9, p. 1216-1234, 2017.

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Doi: 10.21577/1984-6835.20170071

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Boechat, N.; Bastos, M.M. ; Azevedo, L.D. ; Oliveira, A.P . Sínteses e propriedades de fármacos inibidores da tirosina quinase bcr-abl, utilizados no tratamento da leucemia mieloide crônica. Química nova (online) , p. 01-19, 2017.

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Doi:10.21577/0100-4042.20170027

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Azevedo, L.D. ; Bastos, M. M. ; Vasconcelos, F. ; Hoelz, L.V. B. ;  Junior, F. P. ; Dantas, R. F. ; Almeida, A. C. M. ; Oliveira, A. P. ; Gomes, L. C. ; Maia, R. C. ; Boechat, N.  Imatinib derivatives as inhibitors of k562 cells in chronic myeloid leukemia. Medicinal chemistry research, v. 26, p. 2929-2941, 2017.

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Doi: 10.1007/s00044-017-1993-8

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Faria, J.V. ; Vegi, P.F. ; Miguita, A.G.C. ; Santos, M.S. ; Boechat, N. ; Bernardino, A.M.R. Recently reported biological activities of pyrazole compounds. Bioorganic & medicinal chemistry, v. 25, p. 5891-5903, 2017.

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Doi: 10.1016/j.bmc.2017.09.035

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Venâncio, T.; Oliveira, L.M. ; Ellena, J. ; Boechat,N. ; Brown, S.P.  Probing intermolecular interactions in a diethylcarbamazine citrate salt by fast mas 1 h solid-state nmr spectroscopy and gipaw calculations. Solid state nuclear magnetic resonance , v. 87, p. 73-79, 2017.

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Doi: 10.1016/j.ssnmr.2017.02.006

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Sacramento, C.Q.M.; Freitas, C.S.G.; Rocha, N.H.; Miranda,L.V.B.; rodrigues, natalia Marttorelli,M.F.; Ferreira, A.C.A.; Lima, G.A.B.; Vieira,J.L.; Bastos,Y.R.; Volotão,M.M; Nunes, E.M.; Tschoeke,E.P. ;Leomil,D.A. Loiola,L. Trindade, E.C.; Rehen,P.; Bozza,S.K.; Bozza,F.A.;  Patrícia T.;  Boechat, N.T.; Filippis,F.L. Ana M. B.  Corrigendum: the clinically approved antiviral drug sofosbuvir inhibits zika virus replication. Scientific reports, v. 7, p. 46772, 2017.

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Doi: 10.1038/srep46772.

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Sobrinho, A.P.; Minho, A.S. ; Ferreira, L.L.C. ; Martins, G.R. ; Boylan, F. ; Fernandes, P.D . Characterization of anti-inflammatory effect and possible mechanism of action of action of Tibouchina granulosa. Journal of pharmacy and pharmacology , v. 1, p. Early view, 2017.

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Doi:10.1111/jphp.12712

Silva, E.R. ; Bizzo, H.R. ; Fernandes, P.D. ; Junior, V.F.V. ; Leitão, S.G. ; Oliveira, D.R. Development and evaluation of an inhalation chamber for in vivo tests. Anais da academia brasileira de ciencias , v. 1, p. 1-11, 2017.

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Doi:10.1590/0001-3765201720160793

Guerra, F.S.; Oliveira, R.G.; Fraga, C.A.M.; Mermelstein, C.S.; Fernandes, P.D . Rock inhibition with fasudil induces beta-catenin nuclear translocation and inhibits cell migration of mda-mb 231 human breast cancer cells. Scientific reports , v. 7, p. 13723, 2017.

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Doi:10.1038/s41598-017-14216-z

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Leitão, G.G. ; Pereira, J.P.B. ; Carvalho, P.R. ; Ropero, D.R. ; Fernandes, P. D. ; Boylan, F . Isolation of quinoline alkaloids from three choisya species by high-speed countercurrent chromatography and the determination of their antioxidant capacity. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy , v. 27, p. 297-301, 2017.

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Doi:10.1016/j.bjp.2017.01.003.

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Kartbaeva, E.B. ; Donald, G.R. ; Sakipova, Z.B. ; Ibragimova, L.N. ; Bekbolatova, E.N. ; Ternynko, I.I. ; Fernandes, P.D. ; Boylan, F.  Antinociceptive activity of cistanche salsa stolons, growing in the republic of kazakhstan. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy , v. 27, p. 587-591, 2017.

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Doi:10.1016/j.bjp.2017.05.013.

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Silva, E.R. ; Oliveira, D.R. ; Fernandes, P.D. ; Bizzo, H.R. ; Leitão, S.G . Ethnopharmacological evaluation of breu essential oils from protium species administered by inhalation. Evidence-based complementary and alternative medicine , v. 2017, p. 1-10, 2017.

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Doi:10.1155/2017/2924171

Simas, D.L.R. ; Reyes, M.S.M. ; Wug, M.A.M. ; Cordeiro, M.S. ; Giorno, T.B.S. ; Taracena, E.A. ; Hernández, B.E.O. ; Arévalo, J.V.M. ; Fernandes, P.D. ; Sabino, J.F.P. ; Silva,A.J.R. Chemical composition and evaluation of antinociceptive activity of the essential oil of cav. From guatemala. Natural product research , v. 1, p. 1-3, 2017.

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Doi:10.1080/14786419.2017.1399376

Amorim, J.L. ; Figueiredo, J.B. ; Amaral, A.C.F. ; Barros, E.G.O. ; Palmero, C. ; Palantinos, M.A. ; Ramos, A.S. ; Ferreira, J.L.P. ; Silva, J.R.A. ; Benjamim, C.F. ; Basso, S.L. ; Nasciutti, L.E.  ; Fernandes, P.D.  Wound healing properties of copaifera paupera in diabetic mice. Plos one , v. 12, p. E0187380, 2017.

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Doi: 10.1371/journal.pone.0187380

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Ribeiro,T. ; Oliveira, J.T. ; Almeida,F.M. ; Tomaz, M.A.; Melo, P.A. ; Marques, S.A. ;  Andrade, G.M. ; Martinez, A.M.B . Blockade of atp p2x7 receptor enhances ischiatic nerve regeneration in mice following a crush injury. Brain research , v. 115, p. 1111-11112, 2017.

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Doi:10.1186/s40409-018-0148-9

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Galvão, I. ; Vago, J. P. ; Barroso, L. C. ; Tavares , L.P.; Junior , C.M.Q.; Costa, V. V. ; Carneiro, F. S. ; Ferreira, T. P. T. ;  Silva , P.M.; Amaral, F. A. ; Souza , L.P.; Teixeira, M. M.  Annexin a1 promotes timely resolution of inflammation in murine gout. European journal of immunology, v. 47, p. 585-596, 2017.

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Doi: 10.1002/eji.201646551

 

Oliveira, L. G. ; Testasicca, M. C.S. ; Vargo , J.P.; Figueiredo, A. B. ; Canavaci, A. ; perucci, L. O. ; Ferreira, T. P. T. ; Coelho, E. A. F. ; Goncalves, D. U. ; Rocha, M. O. C. ; Silva , P;M.; Ferreira, C. N. ; Junior, C.Q. ; Souza, L.P.; Fernandes, A. P. Annexin a1 is involved in the resolution of inflammatory responses during leishmania braziliensis infection. Journal of immunology, v. 198, p. 3227-3236, 2017.

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Doi: 10.4049/jimmunol.1602028

 

Dalmeida, A. P. L.; Silva , P.M.; Chiambarella, B.T. ; Martins, M.A. ; Bernardi, A.  Α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International journal of nanomedicine, v. Volume 12, p. 4479-4491, 2017.

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