Programa de Pós-Graduação em Farmacologia e Química Medicinal
Artigos em periódicos
2021
Rodrigues, D. A. ; Pinheiro, P. S. M. ; Fraga, C. A. M. Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol-3-kinase (PI3K): Current and Future Prospects. ChemMedChem, v. 16, p. 448-457, 2021.
Evangelista, T.C.S. ; Delarmelina, M. ; Addla, D. ; allão, Rafael, A. ; Kaiser, C.R. ; Carneiro, J.W.M.. ; Silva-Jr, F.P. ; Ferreira, S.B. Influence of temperature for the azide displacement in benzodiazepine derivatives: Experimental and DFT study of competing SN1, SN2 and double SN2 reaction pathways. Tetrahedron Letters, v. 68, p. 152937, 2021.
Doi: 10.1016/j.tetlet.2021.152937
Cadoná, F.C. ; Dantas, R.F. ; Mello, G.H. ; Silva-jr, F.P . Natural products targeting into cancer hallmarks: an update on caffeine, theobromine, and (+)-catechin. Critical Reviews in food science and nutrition, v. -, p. 1-20, 2021.
Doi: 10.1080/10408398.2021.1913091
Moreira-filho, j. t. ; De souza neto, L.R. ; Gomes, B.F. ; Dantas, R.F. ; Neves, B.J. ; Furnham, Nicholas ; Owens, R.J. ; Silva-junior, F.P. ; Andrade, C.H . Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence. Frontiers in Immunology, v. 12, p. 1-29, 2021.
Gasparotto, J. ; Senger, M.R. ; Telles de sá moreira, Emilio ; Brum, P.O. ; Carazza Kessler, F.G. ; Peixoto, D.O.; Panzenhagen, A.C. ; Ong,L.K.; Campos Soares, M. ; Reis, P.A. ; Schirato, G.V. ; Góes Valente, W.C. ; Araújo Montoya, B.O. ; Silva, F.P. ; Fonseca Moreira, J.C. ; Dal-pizzol, F. ; Castro-faria-neto, H.C.. ; Gelain, D. P . Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease. Journal of Biological Chemistry, v. 1, p. 100979, 2021.
Doi: 10.1016/j.jbc.2021.100979
Silva-jr, F. Combating Neglected Diseases in the Post-COVID-19 World. Revista Virtual de Química, v. 13, p. 308-309, 2021.
Pimentel,L.C.F.; Hoelz, L.V.B. ; Canzian, H.F. ; Branco, F.S.C. ; De oliveira, A.P. ; Campos, V.R.; silva -Júnior, F.P. ; Dantas, R.F. ; Resende, J.A.L.C. ; Cunha, A.C. ; Boechat, N. ; Bastos, M.M. (Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia. Beilstein Journal of Organic Chemistry, v. 17, p. 2260-2269, 2021.
De oliveira, G.C. ; Rocha, S.C. ; Lopes, M.A.S. ; Paixão, N. ; Alves, S.L.G. ; Pessoa, M.T.C. ; Noël, F.; Quintas, L.E.M. ; Barbosa, L.A. ; Villar, J.A.F.P. ; Cortes, V.F . Implications of synthetic modifications of the cardiotonic steroid lactone ring on cytotoxicity. Journal of Membrane Biology, v. 1, p. 1, 2021.
Doi: 10.1007/s00232-021-00186-x
Acquarone, M. ; Poleto, a. ; Perozzo, A.F. ; Goncalves, P.F.R. ; Panizzutti, R.A. ; Menezes, J.R.L. ; Neves, G.A. ; Barbosa, H.S. Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis. Scientific Reports, v. 11, p. 14029, 2021.
Doi:10.1038/s41598-021-93504-1
Vieira, M.C. ; Monte, F.B.M. ; Dematte, B.E. ; Montagnoli, T.I. ; Montes, G.C. ; Da Silva, J.S. ; Mendez-otero, R. ; Trachez, M.M.; Sudo,R.T. ; Zapata-sudo, G. Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain. Journal of Pain Research, v. Volume 14, p. 857-866, 2021.
Doi: 10.2147/JPR.S295265
Montagnoli, T.I. ; Da silva, J.S. ; Sudo, S.Z. ; Santos, A.D. ; Gomide, G.F. ; SA, M.P.L. ; Zapata-sudo, G. ROCK inhibition as potential target for treatment of pulmonary hypertension. Cells, v. 10, p. 1-24, 2021.
Gubert, F.; Da Silva, J.S. ; Vasques, J.F. ; Goncalves, R.G.J. ; Martins, R.S.; Sa, M.P.L. ; Mendez-otero, R.; Zapata-sudo, G. Mesenchymal stem cells therapies on fibrotic heart diseases. International Journal of Molecular Sciences, v. 22, p. 7447, 2021.
Doi: 10.3390/ijms22147447
Lima, L.M. ; Da Silva, T.F. ; Da Silva Monteiro, C.E. ; Aparecida-Silva, Cristiane ; Bispo Júnior, W. ; De Queiroz, A.C. ; Alexandre-Moreira, M.S. ; Zapata-sudo, G. ; Barreiro, E.J. Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514. Molecules, v. 26, p. 4828, 2021.
Doi: 10.3390/molecules26164828
Teixeira-cruz, J. ; Strauch, M.A. ; Monteiro-Machado, M. ; Tavares-Henriques, M. ; Moraes, J.A. ; Cunha, L. E. R. ; Ferreira, R.S. ; Barraviera, B. ; Quintas, L. ; Melo, P.A . A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization. Toxins, v. 13, p. 30, 2021.
Zanon, P. ; Pizzato, S.B.; Rosa, R. ; Terraciano, P.B. ; Moraes, J.A. ; Beys-da-Silva, W.O. ; Santi, Luc,Lia ; Yates, Jonhr. ; Passos, E.P. ; Barja-fidalgo, C. ; Guimaraes, J.A.; Berger, M. Urine proteomic analysis reveals alterations in heme/hemoglobin and aminopeptidase metabolism during Lonomia obliqua venom-induced acute kidney injury. Toxicology Letters, v. 15, p. 1, 2021.
Doi:10.1016/j.toxlet.2021.01.012
Guimaraes-Bastos, D. ; Frony, A.C. ; Barja-Fidalgo, C. ; Moraes, J.A. Melanoma¿derived extracellular vesicles skew neutrophils into a pro¿tumor phenotype. Journal of Leukocyte Biology, v. 109, p. 10-19, 2021.
Moraes, J.A.; Encarnacao, C. ; Franco, V.A. ; Botelho, L.G. ; Rodrigues, G.P. ; Andrade, I.R. ; Barja-Fidalgo, C. ; Renovato-Martins, M . Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer. Cancers, v. 13, p. 1, 2021.
Stelling, M.P. ; Soares, M.A. ; Cardoso, S.C. ; Motta, J.M. ; De Abreu, J.C. ; Antunes, M.J.M. ; De Freitas, V.G.; Moraes, J.A. ; Castelo-Branco, M.T.L. ; Pérez, C.A. ; Pavão, M.S.G . Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro. Scientific Reports, v. 11, p. 15833, 2021.
Borges, P.A. ; Waclawiak, I. ; Georgii, J.L. ; Fraga-Junior, V.D. ; Barros, J.F.; Lemos, F.S. ; Russo-Abrahao, T. ; Habib, E. M. S. C. B. ; Takiya, C.M. ; Silva, R.C. ; Penido, C. ; Mermelstein, C.S. ; Fernandes, J.R.M. ; Canto, F. ; Neves, J.S.; Melo, P.A. ; Canetti, C. ; Benjamim, C.F. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Frontiers in Immunology, 2021.
Doi: 10.3389/fimmu.2021.651740
Mendonca-reis, E. ; Nobre, C.C.G. ; Paes-Chagas, A. ; Miranda-Alves, L. ; Berto-Junior, C. Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2021.
Doi: 10.23937/2469-5696/1410048
Teixeira, M.P. ; Passos, E.F. ; Haddad, N.F. ; Andrade, M.N. ; Rumjanek, V.M. ; Miranda-Alves,L. ; Carvalho, D. P. ; Paiva, L. S. In vitro antitumoral effects of the steroid ouabain on human carcinoma cell lines. Environmental Toxicology (online), v. 36, p. 1338-1348, 2021.
Vasconcellos, M. ; Carra, A.M. ; Franco, O.B. ; Baetas-da-Cruz, W. ; Ferreira, M. L. ; Silva, P.C. ; Miranda-Alves, L. ; Carvalho, D.P. ; Schanaider, A. Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism. Frontiers in Endocrinology, v. 12, p. 625171, 2021.
Peixoto, M.S. ; De Vasconcelos e Souza, A. ; Andrade, I.S. ; De Carvalho el Giusbi, C. ; Coelho Faria, C.; Hecht, F. ; Miranda-Alves, L. ; Ferreira, A.C.F. ; Carvalho, D.P. ; Fortunato, R.S.; Rodrigo, S . Hypothyroidism induces oxidative stress and DNA damage in breast. Endocrine-Related Cancer, v. 28, p. 505-519, 2021.
Doi: 10.1530/ERC-21-0010
Guimaraes-Nobre, C.C. ; Mendonca-Reis, E. ; Costa, L.P. ; Miranda-Alves, L.; Berto-Junior, C. Signaling pathway in the osmotic resistance induced by angiotensin II AT2 receptor activation in human erythrocytes. Reports of Biochemistry and Molecular Biology, v. 10, p. 314-326, 2021.
Zanol, J.F. ; Nino, O.M. ; Costa, C.S. ; Freitas-Lima, L.C. ; Miranda-Alves, L. ; Gracelli, J.B. Tributyltin and high¿refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats. Reproductive Toxicology, v. 103, p. 108-123, 2021.
Doi:10.1016/j.reprotox.2021.06.004
Romanelli, M.A. ; Soeiro, P.A. ; Costa da Silva, R.; Taveira-da-Silva, R. ; Melo, P.A. ; Lara, L.S. Revisiting the acute kidney injury in wistar rats experimentally envenomated wity Bothrops jararacussu Venom.. Toxicon, v. 8, p. S0041-0101(21)00174-4, 2021.
Doi:10.1016/j.toxicon.2021.06.004
Soeiro, P.A. ; Romanelli, M.A. ; Cesar, M.O. ; Nogueira-Souza, P.D. ; Monteiro-Machado, M. ; Oliveira, S.S.C. ; Santos, A.L.S. ; Melo, P.A. ; Lara, L. S. . Doxycycline treatment reestablishes renal function of Wistar rats in experimental envenomation with Bothrops jararacussu venom. Toxicon, v. 199, p. 20-30, 2021.
Doi:10.1016/j.toxicon.2021.05.008
Jannuzzi, L.B. ; Pereira-Acacio, A. ; Ferreira, B.S.N. ; Silva-Pereira, D. ; Veloso-Santos, J.P.M. ; Alves-Bezerra, D.S. ; Lopes, J.A. ; Costa-Sarmento, G. ; Lara, L.S. ; Vieira, L.D. ; Abadie-Guedes, R.; Guedes, R.C.A. ; Vieyra, A. ; Muzi-Filho, H. Undernutrition - thirty years of the Regional Basic Diet: the legacy of Naíde Teodósio in different fields of knowledge. Nutritional Neuroscience, v. 19, p. 1-22, 2021.
Doi:10.1080/1028415X.2021.1915631
Kinoshita, P.F. ; Orellana, A.M.M. ; Nakao, V.W. ; Souza Port´s, N.M. ; Quintas, L.E.M. ; Kawamoto, E.M. ; Scavone, C . The Janus face of Ouabain in Na+/K+-ATPase and calcium signalling in neurons. British Journal of Pharmacology, v. 1, p. 1, 2021.
Doi: 10.1111/bph.15419
Kawamoto, E.M. ; Cararo-Lopes, M.M. ; Kinoshita, P.F. ; Quintas, L.E.M. ; Lima, L.S. ; Andreotti, D.Z. ; Scavone, C. Influence of Nitric Oxide-Cyclic GMP and Oxidative STRESS on Amyloid-β Peptide Induced Decrease of Na,K-ATPase Activity in Rat Hippocampal Slices. Journal of Membrane Biology, v. 1, p. 1, 2021
Doi:10.1007/s00232-021-00196-9
Ferreira Abrao, C.; Ribeiro de Oliveira, D.; Passos,P. ; Rodrigues Pereira Freitas, C.V. ; Ferreira Santana, A. ; Lopes da Rocha, M. ; Ribeiro da Silva, A.J. ; Wanderley Tinoco, L. Zootherapeutic practices in the Amazon Region: chemical and pharmacological studies of Green-anaconda fat (Eunectes murinus) and alternatives for species conservation. Ethnobiology and Conservation, v. 10, p. 1-31, 2021.
Forero, A.M.; Castellanos, L.; Sandoval'hernández, A.G.; Magalhães,A.; Tinoco, L.W. ; Lopez'vallejo, F. ; Ramos, F.A. Integration of NMR studies, computational predictions, and assays in the search of marine diterpenes with antitumor activity. Chemical Biology & Drug Design, v. 00, p. cbdd.13907-15, 2021.
Lorenzoni, R.; Contri, R.V.; Lima, C. K. F.; Barreto, F. ; Araujo, B. V.; Pohlmann, A.R. ; Miranda, A.L.P. ; Costa, T.D. ; Guterres, S.S . Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal of Pharmaceutics, v. 596, p. 120294, 2021.
Doi: 10.1016/j.ijpharm.2021.120294
Robba, C.; Battaglini, D. ; Ball, L.; Valbusa, A. ; Porto, I. ; Bona, R.D.; Malfa, G. ; Patroniti, N. ; Brunetti, I. ; Loconte, M. ; Bassetti, M. ; Giacobbe, D. R. ; Vena, Antonio ; Silva, C.L. M. ; Rocco, P. R. M. ; Pelosi, P. Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine, v. 10, p. 140, 2021.
Doi: 10.3390/jcm10010140
Santana, M. V. S. ; Silva, F. P. De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning. BMC Chemistry, v. 15, p. 8, 2021.
Doi:10.1186/s13065-021-00737-2
Silva, J. S. ; Montagnoli, T. L. ; Rocha, B. S. ; Tacco, M. L. C. A. ; Marinho, S. C. P. ; Sudo, G.Z . Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction. International Journal of Molecular Sciences, v. 22, p. 525, 2021.
Alencar, A. K.N. ; Wang, H. ; Oliveira, G. M.M. ; Sun, X. ; Sudo, G.Z. ; Groban, L. Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction. Arquivos Brasileiros de Cardiologia (eletronic), p. 1, 2021.
Silva, J. ; Thompson'souza, G. A. ; Barroso, Marina Valente ; Neves, J. S. ; Figueiredo, R. T. Neutrophil and eosinophil DNA extracellular trap formation: lessons from pathogenic fungi. Frontiers in Microbiology, 2021.
Barroso, M.V. ; Gropillo, I. ; Detoni, M. ; Thompson'souza, G. A. ; Vasconcelos, C. I. ; Muniz, V. S. ; Figueiredo, R. T. ; Melo, R. C N ; Neves, J. S. Signaling events driving Aspergillus fumigatus-induced human eosinophils extracellular trap release. Frontiers in Microbiology, 2021.
Couto, J.; Simas, D. ; Silva, M. ; Barth, T. ; Pinto, S.; Tinoco, L.W. ; Freire, D.; Muzitano, M. ; Leal, I. HSCCC Separations of Rutin Esters Obtained by Enzymatic Reaction Catalyzed by Lipase. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2021.
Doi: 10.21577/0103-5053.20200206
Silveira, F. F.; Souza, J. O.; Hoelz, L. V.B. ; Campos, V. R. ; Jabor, V. A.P. ; Aguiar, A. C.C. ; Nonato, M. C. ; Albuquerque, M. G. ; Guido, R. V.C. ; Boechat, N. ; Pinheiro, L.C.S. Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors. European Journal of Medicinal Chemistry, v. 209, p. 112941, 2021.
Doi:10.1016/j.ejmech.2020.112941
Dias, F.; Guerra, F.; Lima, F. ; Castro, Y. ; Ferreira, V. ; Campos, V. ; Fernandes, P. ; Cunha, A. Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents. Journal of the Brazilian Chemical Society, v. 1, p. 1-14, 2021.
Doi.org/10.21577/0103-5053.20200202.
Carvalho, P.R.; Sirois, P.; Fernandes, P.D. The role of kallikrein-kinin and renin-angiotensin systems in COVID-19 infection. Peptides, v. 135, p. 170428, 2021.
Doi.org/10.1016/j.peptides.2020.170428
Junior, A.T.F.; Anjos, F.F.; Brito, F. C. M. ; Viana, V.G.F. ; Valença, S.S. ; Lanzetti, M. ; Finotelli, P.V. Bixin loaded on polymeric nanoparticles: synthesis, characterization, and antioxidant applications in a biological system. Applied Nanoscience, v. 11, p. 63-78, 2021.
Doi: 10.1007/s13204-020-01555-z
2020
Franco, L.S.; Maia, R.C.; Barreiro, E.J. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (MPRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model. RSC Medicinal Chemistry. 12, 110–119.
Silva, N. L. C.; Mota, N. A. V. ; Soares, M. A. ; Araujo, O.M.O.; Espindola, L. C. P. ; Colombo, A. P. V. ; Lopes, R. T. ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.
Doi: 10.1111/jre.12730
Rodrigues, D. A.; Pinheiro, P.S.M. ; Sagrillo, F.S. ; Freitas, M.C.R. ; Alves, M.A, ; Thota, S. ; Tinoco, L.W. ; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-Property Relationship Studies of 3-Acyl-Substituted Furans: The Serendipitous Identification and Characterization of a New Non-Classical Hydrogen Bond Donor Moiety. New Journal of Chemistry, v. 44, p. 10994-11005, 2020.
Doi.org/10.1039/D0NJ01598A
Rodrigues, D. A ; Pinheiro, P. S. M. ; Sagrillo, F. S. ; Bolognesi, M. L. ; FRAGA, C. A. M. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Medicinal Research Reviews, v. 40, p. 2177-2211, 2020.
Doi: 10.1002/med.21701
Cunha, T.T.S.; Souza, F. R.; Pinheiro, P. S.M.; Sant’anna, C. M.R.; NOËL, F.; França, T.C. C.; Fraga, C.A.M. Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin. CNS & Neurological Disorders-Drug Targets, v. 19, p. 437-447, 2020.
Doi: 10.2174/1871527319999200817153150
Viegas, C. ; Fraga, C. A. M.; Sousa, M. E. ; Tarozzi, A . Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?. Frontiers in Pharmacology, v. 11, p. 609274, 2020.
Thorstenberg, M. L. ; Martins, M. D. A. ; Figliuolo, V. ; Silva, C.L. M ; Savio, L.E. ; Silva, R.C . P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion. Mediators of Inflammation, v. 2020, p. 1-11, 2020.
Oliveira, N.F.; Silva, C.L.M. Unveiling the potential of purinergic signaling in schistosomiasis treatment. Current Topics in Medicinal Chemistry, v. 20, p. 1, 2020.
Doi: 10.2174/1568026620666200924115113
Teixeira, R. G. S.; Pascual, R.; Araújo, K.G.L.; Brito, M. A. ; RIOS, C. ; C., A. F. ; Gandía, L. ; Silva, C. L. M. ; Machado, T. B. ; Santos, Wilson,C. In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone. Natural Product Research. V. 1, p. 1-6, 2020.
Doi: 10.1080/14786419.2020.1739675
Pauli, F. P.; Martins, J. R.; Paschoalin, T. ; Ionta, M. ; Barbosa, M. L. C. ; Barreiro, E. J. Novel VEGFR-2 inhibitors with an N</i> -acylhydrazone scaffold. Archiv Der Pharmazie, v. 276, p. e2000130., 2020.
Alves, M. A.;Queiroz, A. C. ; Leite, A. B. ; Martins, F.T. ; Doriguetto, A. C. ; Barreiro, E. J. ; Moreira, M. S. A. ; Lima, L. M. Carbamoyl- N</i> -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.
Pedreira, J. G. B.; Nahidino, P.; Kudolo, M.; Pantsar, T.; Berger,B.T. ; Forster, M. ; Knapp, S.; Laufer, S. ; Barreiro, E. J. Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 alpha MAP Kinase Inhibitors. Journal Of Medicinal Chemistry, v. 63, p. 7347-7354, 2020.
Doi:10.1021/acs.jmedchem.0c00508
Colodette, N. M.; Franco, L. S.; Maia, Rodolfo C.; Fokoue, H. H.; Sant’anna, C. M. R.; Barreiro, E. J. Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models. Journal Of Computer-aided Molecular Design, v. 34, p. 1091-1103, 2020.
Doi:10.1007/s10822-020-00327-9
Lima, L. M. ; Silva, B. N. M.; Barbosa, G. ; Barreiro, E. J. β-lactam antibiotics: An overview from a medicinal chemistry perspective. European Journal Of Medicinal Chemistry, v. 208, p. 112829, 2020.
Doi:10.1016/j.ejmech.2020.112829
Senger, M. R. ; Evangelista, T. C. S. ; Dantas, R. F. ; Santana, M. V. S. ; Gonçalves, L. C. S.; Neto, L. R.S. ; Ferreira, S. B. ; Junior, F. P.S . COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, v. 115, p. 1, 2020.
Doi.org/10.1590/0074-02760200254
Neto, L.R.S.; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in Chemistry, v. 8, p. 1-18, 2020.
Doi.org/10.3389/fchem.2020.00093
Issy A.C.; Pedrazzi, J. F. C.; Van Oosten, A. B. S.; Checheto, T.; Silva, R. R.; Noel, F.; Del-bel, E. Effects of doxycycline in Swiss mice predictive models of schizophrenia. Neurotoxicity Research, v. 101007, p. s1264002000268z, 2020.
Doi: 10.1007/s12640-020-00268-z
Silva, M. M. C.; Alencar, Nogueira, A.K.; Silva, J.S.; Montagnoli, T.L.; Silva, G.F.; Rocha, B.S.; Montes, G.C.; Otero, R.M.; Coelho, P.M.P.; Vasques, J. F.; Trahez, M.M.; Sudo, R.T.; Sudo, G.Z. Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, v. 9, p. 2120, 2020.
Borsoi, M. ; Nunes, L. E. D. ; Barbosa, A. R. ; Lima, M. S. ; Medeiros, I. ; Pranke, M. A. ; Antonio, C. B. ; RATES, S. M. K. ; Neves, G.A. Intermittent repeated stress but not ketamine changes mice response to antidepressants. Neuroscience Letters, p. 135452, 2020.
Doi: 10.1016/j.neulet.2020.135452
Silva, J. C.; Rodrigues, N. C.; Thompson'souza, G. A.; Muniz, V. S.; Neves, J. S.; Figueiredo, R. T. Mac-1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination. Journal of Leukocyte Biology, v. 107, p. 69-83, 2020.
Nino, O. M.; Costa, C. S.; Torres, K. M.; Zanol, J. F.; Lima, L. C. F.; Alves, L.M.; Graceli, J. B. High refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats. Toxicology Letters, v. 332, p. 42-55, 2020.
Doi.org/10.1016/j.toxlet.2020.07.002
Graceli, J. B.; Dettogni, R. S.; Merlo, E.; Nino, O. M.; Costa, C. S.; Zanol, J. F.; Morris, E. A. R. ; Alves, L.M. ; Denicol, A. C. The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Molecular and Cellular Endocrinology, v. 518, p. 110997-111017, 2020.
Doi.org/10.1016/j.mce.2020.110997
Junior, N. C.L.; Camilo, J. F.; Carmo, P. R.; Andrade, M. N.; Braz, B. F.; Santelli, R. E.; Gitirana, L. B.; Ferreira, A. C. F. ; Carvalho, D. P. ; Alves, L.M. ; Dias, G. R. M. Subacute Exposure to Lead Promotes Disruption in the Thyroid Gland Function in Male and Female Rats. Environmental Pollution, 2020.
Doi:10.1016/j.envpol.2020.115889
Chagas, A.P.; Peixoto, B.P.; Costa, B.B.; Moreira, T.A.; Cinelli, L.P.; Silva, L.L.; Alves, L.M.; Junior, C.B. Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic. Toxicology Mechanisms and Methods, v. 31, p. 1-34, 2020.
Doi:10.1080/15376516.2020.1836102
Almeida, J.; Oliveira, V.R.; Avelar, J.L.S.; Moita, B.S.; Lima, L.M. COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química, 2020, 12 (6), 1464-1497.
Curnow, A. C.; Gonsalez, S. R.; Gogulamudi, V. R.; Visniauskas, B. ; Simon, E. E. ; Gonzalez, A. A. ; Majid, D. S. A. ; Lara, L.S. ; Prieto, M. C. Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct. Frontiers in Physiology, v. 11, p. 153, 2020.
Doi.org/10.3389/fphys.2020.559341
Ortiz, M.; Coutinho, D. S.; Ciambarella, B. T.; Souza, E.; Leite, A. P.; Durli, T. L.; Silva, P. M. R.; Bernardi, A.; Sonvico, F.; Pohlmann, A. R.; Martins, M. A.; Guterres, S. S. Intranasal administration of budesonide-loaded nanocapsule-microagglomerates as an innovative strategy for asthma treatment. Drug Delivery and Translational Research, 2020.
Doi.org/10.1007/s13346-020-00813-5
Coutinho, D. S.; Pires, J.; Gomes, H.; Pohlmann, A.; Guterres, S.; Silva, P. M. R. E.; Ferrarini, S.; Bernardi, A.; Martins, M.A. Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice. Pharmaceutics, v. 12, p. 1075, 2020.
Doi: 10.3390/pharmaceutics12111075.
Insuela, D. B. R.; Ferrero, M.R.; Coutinho, D. S.; Martins, M. A.; Carvalho, V. F. Could Arachidonic Acid-Derived Pro-Resolving Mediators Be a New Therapeutic Strategy for Asthma Therapy?. Frontiers in Immunology, v. 11, p. 1-9, 2020.
Mello, F.V.C.; Quaresma, B.M.C.S.; Pitombeira, M.C.R.; Brito, M.A.; Farias, P.P.; Castro, S.L.; Salomão, K.; Carvalho, A.S.; Paula, J.I.O.; Nascimento, S.B.; Cupello, M.P.; Paes, M.C; Boechat, N.; Felzenszwalb, Israel . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European Journal of Medicinal Chemistry, v. 186, p. 111887-111902, 2020.
Boechat, N.; Carvalho, R. C.C. ; Ferreira, M.L. G. ; Coutinho, J.P.; Sa, P.M. ; Seito, L. N. ; Rosas, E. C. ; Krettli, A.U. ; Bastos, M. M. ; Pinheiro, L. C.S. Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. Bioorganic & Medicinal Chemistry, v. 28, p. 115832-115846, 2020.
Doi: 10.1016/j.bmc.2020.115832.
Pinheiro, L.C.S.; Hoelz, L.V.B.; Ferreira, M.L.G.; Oliveira, L.G.; Pereira, R.F.A.; Valle, A.M.; André, L.S.P.; Scaffo, J.; Pinheiro, F.R.; Ribeiro, T.A.N.; Sachs, D.; Pascoal, A.C.R.F.; Boechat, N.; Aguiar'alves, F. Synthesis of benzoylthiourea derivatives and analysis of their antibacterial performance against planktonic Staphylococcus aureus and its biofilms. Letters in Applied Microbiology, v. 71, p. 645-651, 2020.
Souza, A. A. A. ; Torres, L. R. ; Capobianco, L. R. P. L. ; Paula, V. S. ; Cascabulho, C. M. ; Salomao, K. ; Almeida, M. G. B. ; Ferreira, M.L G. ; Boechat, N. ; Pinheiro, L. C. S. ; Souza, E. M. Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells. Viruses-Basel, v. 13, p. 1-15, 2020.
Doi: 10.3390/v13010036.
Martins, D.L.; Borges, A.A.; Silva, N. A.; Faria, J.V.; Hoelz, L.V.B.; Souza, H.V.C.M.; Bello, M.L.; Boechat, N.; Ferreira, V.F.; Faria, R.X. P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones. Bioorganic Chemistry, v. 104, p. 104278-104289, 2020.
Doi: 10.1016/j.bioorg.2020.104278.
Ferreira, T. P. T.; JG, Lima; Filho, F.F. ; SA, Y. A. P. J. ; AC, Arantes ; Guimaraes, F. V. ; V, Carvalho ; Hogaboam, C M ; J, Wallace ; Martins, M. A. ; Silva, PM . Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Frontiers in Endocrinology, v. 11, p. 388, 2020.
Ventura, R. D. ; Chaves, A. S. ; Magalhaes, N. S. ; Gonzalez, F. B. ; Pacini, M. F. ; Perez, A. R. ; Silva, P. M. R. ; M.A., Martins ; VF, Carvalho . Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. Free Radical Biology and Medicine, v. 156, p. 137-143, 2020.
Nunes, I. K. C.; Souza, E. T.; Martins, I. R. R.; Barbosa, G. ; Junior, M. O. M.; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, Carvalho ; Martins, M. A. ; Lima,L.M . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.
Doi: 10.1016/j.ejmech.2020.112492.
Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S. ; Silva, E.T. ; Souza, M.V. N.; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A. Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology, v. 11, p. 1159, 2020.
Doi.org/10.3389/fphar.2020.01159
Cavalieri,I.C.P.; Valenca, H. M. ; Moraes, J.A. ; Gitirana, L.B.; Souza, B.R. ; Schmidt, M ; Valença, S.S . Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice. International Journal of Molecular Sciences, v. 21, p. 9658, 2020.
Nascimento, M.S.S. ; Câmara, V.R.F. ; Costa, J.S. ; Barbosa, J.M.C. ; Lins, A.S.M. ; Salomão, K. ; Castro, S.L.; Carvalho, S.A. ; Silva, E.F. ; Ferreira. E.; ; Fraga, C.A.M. Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates. Medicinal Chemistry , v. 16, p. 774-783, 2020.
Doi:10.2174/1573406415666190627103013
Araujo-montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; Silva-jr, F.P. Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells. Protein Expression and Purification, v. 167, p. 105532, 2020.
Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical Pharmacology , v. 171, p. 113679, 2020.
Doi: 10.1016/j.bcp.2019.113679
Costa, G. ; Montagnoli, T. L. ; Da SILVA, J. S. ; Alencar, A. K. N. ; Gamba, L. E.R. ; Alves, B. E.O. ; Moraes, M. C. ; Trachez, M. M ; Nascimento, J. H.M. ; Coelho, P.M.P. ; Mendez-otero, R. ; Lima, L.M. ; Barreiro, E.J. ; Sudo, Roberto Takashi ; Sudo, G.Z . New benzofuran N-acylhydrazone reduces cardiovascular dysfunction in obese rats by blocking TNF-alpha synthesis. Drug Design Development and Therapy , v. 14, p. 3337-3350, 2020.
Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Selmi-ruby, S. ; Maximo, V. ; Soares, P. ; Alves, L. M. Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and Cellular Endocrinology , v. 502, 2020.
Doi: 10.1016/j.mce.2019.110677
Reis, E.M. ; Nobre, C. C. G. ; Chagas, A.P. ; Alves, L.M. ; Junior, C.B . Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2020.
Doi: 10.23937/2469-5696/1410048
Lindoso, RS ; Lopes, J.A. ; Binato, R. ; Abdelhay, E. ; Takiya, C.M. ; Miranda, K.R. ; Lara, L. S. ; Viola ,A ; Bussolati, B ; Vieyra, A. ; Collino F . Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection. Molecular Therapy-Methods & Clinical Development, v. 16, p. 63-77, 2020.
Doi:10.1016/j.omtm.2019.11.002
Dick, C. F. ; Guimarães, L.M. ; Kelly, L.F.C. ; Cortes, A.L. ; Morcillo, L.L.S. ; Sampaio, L.S. ; Fernandes, J. R.M. ; Vieyra, A. . A ferric reductase of Trypanosoma cruzi (TcFR) is involved in iron metabolism in the parasite. Experimental Parasitology, v. 217, p. 107962, 2020.
Doi:10.1016/j.exppara.2020.107962
Lima, J. A. ; R. Costa, T.W. ; Fonseca, A. C.C. ; Amaral, R. F. ; Nascimento, M.D. S.B. ; Filho, O.A.S. ; Miranda, A.L.P. ; Neto, D.C.F.; Lima, F.R.S. ; Hamerski, L. ; Tinoco, L. W. Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorganic chemistry, v. 104, p. 104215, 2020.
Nunes, I.C.N. ; Souza, E.T. ; Martins, I.R.M. ; Barbosa, G. ; Junior, M.O.N. ; Medeiros, M.M. ; Silva, S. W.D. ; Balliano, T.L.; Silva, B.A. ; Silva, P.M.R.; Carvalho, V.F. ; Martins, M.A.; Lima, L.M. Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 204, p. 112492, 2020.
DOI: 10.1016/j.ejmech.2020.112492
Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S.; Silva, E.T.; Souza, M.V.N. ; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A . Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology , v. 11, p. 1159, 2020.
Doi.: 10.3389/fphar.2020.01159
Pinto, D.P. ; Coutinho, D.S. ; Carvalho, K.I.M. ; Ferrero, M. R. ; Silva, L.V. ; Silveira, G.P. E. ; Silva, D. M.; Araújo, J.F.G. ; Silva, A. C.A. ; Pereira, H.M. ; Fonseca, L.B. ; Faria, R.X. ; Souza, M.V.N. ; Silva, E.T.; Filho, O.A.S. ; Costa, J.C. ; Amendoeira, F. C. ; Martins, M.A. Pharmacological profiling of JME-173, a novel mexiletine derivative combining dual anti-inflammatory/anti-spasmodic functions and limited action in Na+ channels. European Journal of Pharmacology. v. 885, p. 173367, 2020.
Doi:10.1016/j.ejphar.2020.173367
Aguiar, R.P.S. ; Peruchetti, D.B. ; Rocco, P.R.M. ; Schmaier, A.H. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, Vinicius de Frias ; Pinheiro, A.A.S. ; Neves, C.C . Role of the renin angiotensin system in the development of severe COVID-19 in hypertensive patients. AJP: Lung Cellular and Molecular Physiology, 2020.
Doi:10.1152/ajplung.00286.2020
Mattos, M. S. ; Ferrero, M. R. ; Kraemer, L. ; Lopes, G. A. ; Reis, D. C. ; Oliveira, F. M. ; Cassali, G. D. ; Brandolini, L. ; Allegretti, M. ; Garcia, C. C. ; Martins, M.A. ; Teixeira, M. M. ; Russo, R. C. CXCR1 and CXCR2 inhibition by Ladarixin improves neutrophil-dependent airway inflammation in mice. Frontiers in Immunology , 2020.
Silva, M.F. ; Lima, E.T. ; Pruccoli, Letizia ; Castro, N. ; Guimarães, M. ; Silva, F. ; Nadur, N.F. ; Azevedo, L. ; Kümmerle, A. ; Guedes, I.; Dardenne, L. ; Gontijo, V. ; Tarozzi, A. ; Viegas, C. Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer?s Disease. Molecules, v. 25, p. 3165, 2020.
Doi: 10.3390/molecules25143165
Prado, V.M. ; Queiroz, T.B.; Sá, P. M. ; Seiceira, R.C. ; Boechat, N. ; Ferreira, F.F . Mechanochemistry for the production of a hybrid salt used in the treatment of malaria. Green Chemistry, v. 22, p. 51-61, 2020.
Rogerio, K.R. ; Graebin, C.S. ; Domingues, L.H.P. ; Oliveira, L.S. ; Silva, V.S.F.; Ribeiro, C.T.D. ; Carvalho, L. J.M. ; Boechat, N. Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum. Current topics in Medicinal Chemistry, v. 20, p. 99-110, 2020.
Doi: 10.2174/1568026619666191019100711
Nunes, I. K. C. ; Souza, E. T. ; Martins, I. R. R. ; Barbosa, G. ; Junior, M. O.M ; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, C. ; Martins, M. A. ; LM, Lima . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.
Doi: 10.1016/j.ejmech.2020.112492
Silva, N. L. C. ; Mota, N A V ; Soares, M. A. ; Araujo OMO ; Espindola, L C P ; Colombo, A P V ; Lopes, R T ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.
Doi: 10.1111/jre.12730
Gomes, A. C. C. ; Soares, Mariana, A. ; Gomes, A. K. C. ; Silva, Natália, L. C. ; Miranda, A. L. P. ; Tributino, J. L. M. ; LUZ, D. A. ; Amorim, GISELE C. ; Simas, N. K. ; KUSTER, R. M. Antinociceptive constituents from Saccharum officinarum L. juice. Natural product research, v. 34, p. 1-5, 2020.
Doi: 10.1080/14786419.2020.1771708
Rodrigues, D.A. ; Guerra, F.S. ; Sagrillo, F.S.. ; Pinheiro, P.S.M. ; Alves, M.A. ; Thota, S. ; Chaves, L.S. ; Santanna, C.M.R. ; Fernandes, P.D. ; Fraga, C.A.M . Design, Synthesis and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors. ChemMedChem, v. 15, p. 539-551, 2020.
Fokoue, H. ; Pinheiro, P. ; Fraga, C. ; Santanna, C. Há algo novo no reconhecimento molecular aplicado à química medicinal?. Quimica nova, v. 43, p. 78-89, 2020.
Doi: 10.21577/0100-4042.20170474
Freitas, R.H.C.N. ; Barbosa, J.M.C. ; Bernardino, P. ; Sueth-santiago, V. ; Wardell, S.M.S.V. ; Wardell, J. L. ; Ricardo, D. D.; Melo,T.G. ; Silva,E.F. ; Salomão, K. ; Fraga, C.A.M . Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives. Biomedicine & pharmacotherapy, v. 127, p. 110162, 2020.
Doi: 10.1016/j.biopha.2020.110162
Neves, B.J. ; Agnes, J.P. ; Gomes, M.N. ; Donza, M.R.H. ; Gonçalves, R.M. ; Delgobo, M. ; Neto, lauro ; Senger, M.R. R.S. ; Junior, F.P.S. ; Ferreira, S.B. ; Filho, A.Z. ; Andrade, C.H . Efficient identification of novel anti-glioma lead compounds by machine learning models. european journal of medicinal chemistry, v. 189, p. 111981, 2020.
Doi: 10.1016/j.ejmech.2019.111981
Neto, L.R.S. ; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in chemistry, v. 8, p. 1-18, 2020.
françois
Silva, V.D. ; Silva, R.R. ; Neto, J.G. ; Corcuera, B.L. ; Guimaraes, M.Z. ; Noël, F. ; Antonio, C.B. New α-hydroxy-1,2,3-triazoles and 9h-fluorenes-1,2,3-triazoles: synthesis and evaluation as glycine transporter 1 inhibitors. Journal of the brazilian chemical society, v. 31, p. 1258-1269, 2020.
Doi: 10.21577/0103-5053.20200011
Noël, F.; Lima, J. Pharmacological aspects and clues for the rationale use of Chloroquine/Hydroxychloroquine facing the therapeutic challenges of COVID-19 pandemic. Latin American Journal of Clinical Sciences and Medical Technology, v. 2, p. 28-34, 2020.
Bray, M. ; Rayner, C. ; Noël, F. ; Jans, D. ; Wagstaff, K. Ivermectin and COVID-19: a report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. ANTIVIRAL RESEARCH, v. 1, p. 104805, 2020.
Doi: 10.1016/j.antiviral.2020.104805
Noël, F. Suggesting Treatments for COVID-19. Beware! Expectations cannot Replace Good Science. Latin American Journal of Clinical Sciences and Medical Technology, v. 2, p. 43-43, 2020.
Marques, A. M. ; Macena, M. V. ; Cardoso, A. R. ; Hammes, C. S. O. ; Pinheiro, F.M.L. ; Castro, N. G. ; Neves, G.A. Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice. Psychopharmacology, v. (), p. 1-13, 2020.
Doi: 10.1007/s00213-020-05485-0
Rodrigues, D.A. ; Pinheiro, P.S.M. ; Sagrillo, F.S.; Freitas, M.C.R. ; Alves, M.A. ; Thota, S. ; Tinoco, L.; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety. New journal of chemistry, v. 44, p. 10994-11005, 2020.
Thompson'souza, G.A. ; Santos, G.M.P. ; Silva, J.C. ; Muniz, V.S. ; Braga, Y.A.V. ; Figueiredo, R.T. ; Melo, R.C.N. ; Santos, A.L.S. ; Pinto, M.R. ; Neves, J.S. Histoplasma capsulatum -induced extracellular dna trap release in human neutrophils. cellular microbiology, v. x, p. x, 2020.
Sisnande, T. ; Lima, C.K. ; Silva, D.C. ; Moulin ,T.B.. ; Leao, N. ; Amaral, M.J. ; Alves, L.M. ; Lima, L.M.T.R. Dietary zinc restriction promotes degeneration of the endocrine pancreas in mice. Biochimica et biophysica acta-molecular basis of disease, v. 1866, p. 165675, 2020.
Doi: 10.1016/j.bbadis.2020.165675
Reis, E.M. ; Nobre, C.C.G. ; Chagas, A.P. ; Alves, L.M. ; Junior, C.B . Effects of tsh in erythrocyte osmotic fragility: signalling pathway. International journal of blood research and disorders, v. 7, p. 1-7, 2020.
Doi: 10.23937/2469-5696/1410048
Podratz, P.L. ; Merlo, E. ; Araujo, J.F.P. ; Ayub, J.G.M. ; Pereira, A.F.Z. ; Lima, L.C.F. ; Costa, M.B.C. ; Alves, L.M. ; Cassa, S.G.S.C. ; Carneiro, M.T.W.D. ; Fillmann, G. ; Graceli, J.B . Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats. Science of the total environment, v. 723, p. 138000-xxx, 2020.
Doi: 10.1016/j.scitotenv.2020.138000
Alves, Marina A. ; Queiroz, A.C. ; Leite, A.B. ; Martins, F.T. ; Doriguetto, A.C. ; Barreiro, E. J. ; Moreira, M.S.A. ; Lima, L.M. . Carbamoyl- N -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.
Casanova,L.M. ; Rodrigues, L.M. ; Aguiar, P.F. ; Tinoco, L.W . An NMR-Based Chemometric Strategy to Identify Leishmania donovani Nucleoside Hydrolase Inhibitors from the Brazilian Tree Ormosia arborea. Journal of natural products, v. 83, p. 243-254, 2020.
Doi: 10.1021/acs.jnatprod.9b00622
Calassara, L.L. ; Pinto, S.C.; Condack, C.P.M. ; Leite, B.F. ; Nery, L.C.E.S. ; Tinoco, L.W.; Aguiar, F.A. ; Leal, I.C.R. ; Martins, S.M. ; Silva, L.L. ; Raimundo, J.M.; Muzitano, M.F . Isolation and characterization of flavonoids from tapirira guianensis leaves with vasodilatory and myeloperoxidase-inhibitory activities. Natural product research, v. 000, p. 1-4, 2020.
Doi: 10.1080/14786419.2020.1784170
Lourenço, E.M.G. ; Fernandes, J.M. ; Carvalho, V.F. ; Grougnet,R. ; Martins, M.A. ; Jordão, A.K. ; Zucolotto, S.M. ; Barbosa, euzébio g. Identification of a selective pde4b inhibitor from bryophyllum pinnatum by target fishing study and in vitro evaluation of quercetin 3-o-α-l-arabinopyranosyl-(1→2)-o-α-l-rhamnopyranoside. Frontiers in pharmacology, v. 10, p. 1-12, 2020.
Ferreira, T.P.T. ; Lima, J.G.M. ; Filho, F.A.F. ; Sá, Y.A.P.J. ; Arantes, A.C.S. ; Guimarães, F.V. ; Carvalho, V. F. ; Hogaboam, C. ; Wallace, J. ; Martins, M.A. ; Silva, P.M.R . Intranasal flunisolide suppresses pathological alterations caused by silica particles in the lungs of mice. Frontiers in endocrinology, v. 11, 2020.
Ventura,R.D. ; Chaves, A.S. ; Magalhaes, N.S. ; Gonzalez, F.B. ; Pacini, M.F. ; Perez, A.R. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, V.F . Activation of pparγ reduces n-acetyl-cysteine -induced hypercorticoidism by down-regulating mc2r expression into adrenal glands. Free radical biology and medicine, 2020
Doi: 10.1016/j.freeradbiomed.2020.06.008
Marques, A.M. ; Macena, M.V. ; Cardoso, A.R. ; Hammes, C.S.O. ; Pinheiro, F.M.L. ; Castro, N. G. ; Neves, G. A. Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice. Psychopharmacology, v. 00, p. 1-13, 2020.
DOI: 10.1007/s00213-020-05485-0
Pimentel, L.C.F.; Cunha, A.C. ; Hoelz, L.C.B. ; Canzian, H.F. ; Marinho, D.I.L.F. ; Boechat,N. ; Bastos, M.M. Phenylamino-pyrimidine (pap) privileged structure: synthesis and medicinal applications. Current topics in medicinal chemistry, v. 20, p. 227-243, 2020.
Doi: 10.2174/1568026620666200124094949
Cordeiro, N.M. ; Freitas, R.H.C.N. ; Fraga, C.A.M. ; Fernandes, P.D . New 2-amino-pyridinyl-n-acylhydrazones: synthesis and identification of their mechanism of anti-inflammatory action. Biomedicine & pharmacotherapy, v. 123, p. 109739, 2020.
Doi: 10.1016/j.biopha.2019.109739
Cordeiro, M.S. ; Simas, D.L.R. ; Sabino, J.F.P. ; Reyes, M.S.M. ; Muñoz-wug, M.A. ; Oliva-hernández, Bessie, E. ; S.;Antônio ,J.R. ; Fernandes, P.D. ; Giorno, T.B.S . Characterization of the antinociceptive activity from stevia serrata cav. Biomedicines, v. 8, p. 79, 2020.
Doi: 10.3390/biomedicines8040079
Salomé, DC ; Cordeiro, N.M. ; Valerio, T.S. ; Santos, D.A. ; Alves, P.B. ; Alviano, C.S. ; Alviano, D.S. ; Fernandes, PD . Aristolochia trilobata: Identification of the Anti- Inflammatory and Antinociceptive Effects. Biomedicines, v. 8, p. 111-129, 2020.
Doi: 10.3390/biomedicines8050111
Sakipova, Z. ; Giorno, T.B.S. ; Bekezhanova, T. ; Wong, N.S.H. ; Shukirbekova, A. ; Fernandes, P.D. ; Boylan, F . Pharmacological Evaluation of Artemisia cina Crude CO2 Subcritical Extract after the Removal of Santonin by Means of High Speed Countercurrent Chromatography. Molecules, v. 25, p. 2728, 2020.
Doi: 10.3390/molecules25122728
Cordeiro, N.M. ; Freitas, R.H.C.N. ; Fraga, C.A.M. ; Fernandes, P.D . Therapeutic effects of anti-inflammatory n-acylhydrazones in the resolution of experimental colitis. Journal of pharmacology and experimental therapeutics, v. 374, p. jpet-ar-2020-000074, 2020.
Tavares, L. P. ; Negreiros-lima, G. ; Lima, K. M. ; E Silva PM ; Pinho, V. ; Teixeira, M. M. ; Souza LP . Blame the signaling: role of cAMP for the resolution of inflammation. Pharmacological research, 2020.
Doi: 10.1016/j.phrs.2020.105030
Souza, B.R. ; Saguie , B.O.; Nogueira , N.P.A.; Paes , M. ; Valença, S.S. ; Atella , G.C. ; Costa, A.M.A. Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-κB and NRF2 pathways. Food research international, v. 131, p. 108984, 2020.
Doi: 10.1016/j.foodres.2020.108984
Alves, D.R.F. ; Pinto, J.B. ; Rodrigues, F.R. ; Valverde, P. ; Fernandes, D.C.S. ; Accioly, M. ; Valenca, S.S. ; Perini, J.A. ; Jorge, R.V . Cox-2 expression in breast cancer and impact on survival outcomes. Journal of cancer science and clinical therapeutics, v. 04, p. 120-132, 2020.
Cattani-cavalieri, I. ; Valença, S.S. ; Schmidt, M . Nanodomains in cardiopulmonary disorders and the impact of air pollution. Biochemical society transactions, v. 05, p. 50, 2020.
Cordeiro, N.M. ; Freitas,R.H.C.N. ; Fraga, C.A.M ; Fernandes, P.D . New 2-amino-pyridinyl-n-acylhydrazones: synthesis and identification of their mechanism of anti-inflammatory action. Biomedicine & pharmacotherapy, v. 123, p. 109739, 2020.
Doi: 10.1016/j.biopha.2019.109739
Montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; JunioR, F.P.S. Schistosoma mansoni cathepsin d1: biochemical and biophysical characterization of the recombinant enzyme expressed in hek293t cells. Protein expression and purification , v. 167, p. 105532, 2020.
Doi: 10.1016/j.pep.2019.105532
Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F.G. . Conformational states of the pig kidney na+/k+-atpase differently affect bufadienolides and cardenolides: a directed structure-activity and structure-kinetics study. Biochemical pharmacology , v. 171, p. 113679, 2020.
Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Ruby, S.S. ; Maximo, V. ; Soares, P. ; Alves, L.M . Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and cellular endocrinology , v. 502, p. 110677. 2020.
Prado,V.M.; Queiroz,T.B.; Sá,P.M. ; Seiceira, R.C.; Boechat, N. ; Ferreira,F.F. Mechanochemistry for the production of a hybrid salt used in the treatment of malaria. Green chemistry , v. 22, p. 51-61, 2020.
Rogerio,K.R. ; Graebin, C. S. ; Domingues, L. H. P. ; Oliveira, L. S. ; Silva, V. S. F. ; Ribeiro, D.C. T. ; Carvalho, L. J. M. ; Boechat, N. Novel quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives against chloroquine-resistant plasmodium falciparum. Current topics in medicinal chemistry , v. 20, p. 99-110, 2020.
Doi: 10.2174/1568026619666191019100711
Marques, A.M., Macena, M.V., Cardoso, A.R. et al. Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice. Psychopharmacology 237, 1643–1655 (2020).
Doi: 10.1007/s00213-020-05485-0
Costa-Filho, R.C.; Castro-Faria Neto, H.C. ; Mengel, J. ; Pelajo-Machado, M. ; Martins, M.A. ; Leite, E.T. ; Mendonca-Filho, H.T. ; Souza, T.A.C.B. ; Bentacor, G.B. ; Leite, J.P.G . Should COVID-19 be branded to viral thrombotic fever?. Memorias DO Instituto Oswaldo Cruz, v. 116, p. e200552, 2021.
De Oliveira, M.T.P. ; Coutinho, D.S. ; Guterres, S.S. ; Pohlmann, A.R. ; Silva, P.M.R. ; Martins, M.A. ; Bernardi, A . Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice. Pharmaceutics, v. 13, p. 683, 2021.
Doi: 10.3390/pharmaceutics13050683
Insuela, D.B.R.; Ferrero, M.R. ; Gonçalves-de-Albuquerque, C.F. ; Chaves, A.S. ; Da Silva, A.Y. O. ; Castro-Faria-Neto, H.C. ; Simões, R.L. ; Barja-Fidalgo, T.C. ; Silva, P.M.R. ; Martins, M.A. ; Silva, A.R. ; Carvalho, V.F. Glucagon Reduces Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice. Frontiers in Immunology, v. 12, p. 633540, 2021.
Doi: 10.3389/fimmu.2021.633540
Ferrero, M.R.; Garcia, C.C. ; Dutra de Almeida, M.; Torres Braz da Silva, J. ; Bianchi Reis Insuela, D. ; Teixeira Ferreira, T.P. ; Coutinho, D.S. ; Trindade de Azevedo, C. ; Silva, P.M.R. ; Martins, M.A. CCR5 Antagonist Maraviroc Inhibits Acute Exacerbation of Lung Inflammation Triggered by Influenza Virus in Cigarette Smoke-Exposed Mice. Pharmaceuticals, v. 14, p. 620, 2021.
Doi: 10.3390/ph14070620
Magalhães, N.S. ; Savino, W. ; Silva, P.M.R. ; Martins, M.A. ; Carvalho, V.F. Gut Microbiota Dysbiosis Is a Crucial Player for the Poor Outcomes for COVID-19 in Elderly, Diabetic and Hypertensive Patients. Frontiers in Medicine, v. 8, p. 1-11, 2021.
Souza, A.A.A. ; Torres, L.R.; Capobianco, L.R.P.L. ; Paula, V.S. ; Cascabulho, C.M. ; Salomao, K. ; Bonecini-Almeida, M.G. ; Ferreira, M.L.G. ; Boechat, N. ; Pinheiro, L.C.S. ; Souza, E.M. Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells. Viruses-Basel, v. 13, p. 36, 2021.
Doi: 10.3390/v13010036
Sacramento, C.Q.F.R.; Natalia Temerozo, J.R.S.; Dias,A.P.; Gomes, S.S.;Ferreira, C.S; mattos,A.C.; Mayara Pão; Freitas,C.R.R.; Soares,C.S.; Hoelz, V.C.; Fernandes,L.V.B.; Branco, T.V.A.; Bastos,F.S.C.; Macedo, M.; Boechat, N.; Saraiva, Felipe B Ferreira; Jockusch,M.A.; Wang,S.; Tao,X.; Chien,C.; Xie,M.; Patel,W.; Garzia,D.; Aitor , et al. Antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19. Journal of Antimicrobial Chemotherapy, v. 76, p. 1874-1885, 2021.
Doi: 10.1093/jac/dkab072
Ferreira Pimentel, L.C. ; Hoelz, L.V.B. ; Canzian, H.F. ; Branco, F.S.C. ; Oliveira, A.P. ; Campos, V.R. ; S Junior, F. P. ; Dantas, R.F. ; Resende, J.A.L.C. ; Cunha, A.C. ; Boechat, N. ; Bastos, M.M. (Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia. Beilstein Journal of Organic Chemistry, v. 17, p. 2260-2269, 2021.
Bianco, M.A.C.D. ; Leite, D.I.. ; Hoelz, L.V.B. ; Bastos, M.M. ; Boechat, N. Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors. Pharmaceuticals, v. 14, p. 893, 2021.
Amorim, J.L. ; Lima, F.A. ; Brand, A.L.M. ; Cunha, S. ; Rezende, C.M. ; Fernandes, P.D. Two New βN-Alkanoyl-5-Hydroxytryptamides with Relevant Antinociceptive Activity. Biomedicines, v. 9, p. 455, 2021.
Doi:10.3390/biomedicines9050455
Guerra, F.S. ; Rodrigues, D.A. ; Fraga, C.A.M. ; Fernandes, P.D. Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer. PHARMACEUTICALS, v. 14, p. 387, 2021.
Doi: 10.3390/ph14050387
Giorno, T.B.S.; Lima, F.A.; Brand, A.L.M.; Oliveira, C.M. ; Rezende, C.M. ; Fernandes, P.D. Characterization of βN-Octadecanoyl-5-hydroxytryptamide Anti-Inflammatory Effect. Molecules, v. 26, p. 3709-3722, 2021.
Guerra, F.S. ; Dias, F.R.F. ; Cunha, A.C.; Fernandes, P.D. Benzo[f]indole-4,9-dione Derivatives Effectively Inhibit the Growth of Triple-Negative Breast Cancer. Molecules, v. 26, p. 4414, 2021.
Doi: 10.3390/molecules26123709
Donald, G.R. ; De Carvalho, P.R. ; Fernandes, P.D. ; Boylan, F . Antinociceptive activity of puberulin and choisyine from ethanol extract of Choisya ternata Kunth var. Sundance. Biomedicine & Pharmacotherapy, v. 141, p. 111926, 2021.
Doi: 10.1016/j.biopha.2021.111926
Teixeira-Cruz, J.M. ; Strauch, M.A. ; Monteiro-Machado, M. ; Tavares-Henriques, M.S. ; De Moraes, J.A. ; Ribeiro da Cunha, L.E. ; Ferreira, R.S.Jr. ; Barraviera, B. ; Quintas, L.E.M. ; Melo, P.A . A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization. Toxins, v. 1111, p. 1111-11, 2021.
Borges, P.A. ; Waclawiak, I. ; Georgii, J.L. ; Fraga-Junior, V.S. ; Barros, J.F. ; Lemos, F.S. ; Russo-Abrahão, T. ; Saraiva, E.M. ; Takiya, C.M. ; Coutinho-Silva, R. ; Penido, C. ; Mermelstein, C.; Meyer-Fernandes, J.R. ; Canto, F.B. ; Neves, J.S. ; Melo, P.A. ; Canetti, C. ; Benjamim, C.F. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Frontiers in Immunology, v. 12, p. 1111-11111, 2021.
Doi: 10.3389/fimmu.2021.651740
Nascimento, L.S. ; Nogueira-Souza, P.D. ; Rocha-Junior, J.R.S. ; Monteiro-Machado, M. ; Strauch, M.A. ; Prado, S.A.L. ; Melo, P.A. ; Veiga-Junior, V.F. Phytochemical composition, antisnake venom and antibacterial activities of ethanolic extract of Aegiphila integrifolia (Jacq) Moldenke leaves. Toxicon, v. 198, p. 121-131, 2021.
Doi: 10.1016/j.toxicon.2021.05.004.
Romanelli, M.A. ; Soeiro, P.A. ; Costa da Silva, R. ; Taveira-da-Silva, R. ; Melo, P.A. ; Lara, L.S. Revisiting the acute kidney injury in wistar rats experimentally envenomated wity Bothrops jararacussu Venom. Toxicon, v. 1111, p. 1111-1111, 2021.
Doi: 10.1016/j.toxicon.2021.06.004
Teixeira-Cruz, J.M. ; Strauch, M.A. ; Monteiro-Machado, M. ; Tavares-Henriques, M.S. ; De Moraes, J.A.; Ribeiro da Cunha L.E. ; Ferreira, R.S. Jr. ; Barraviera, B. ; Quintas, L.E.M. ; Melo, P.A. A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization. Toxins, v. 1111, p. 1111-11, 2021.
Martino, T. ; Kudrolli, T.A. ; Kumar, B. ; Salviano,I. ; Mencalha,A. ; Coelho, M.G.P. ; Justo, G. ; Costa, P.R.R. ; Sabino, K.C.C.; Lupold, S.E . The orally active pterocarpanquinone lqb-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress. Prostate, v. 78, p. 140-151, 2018.
Leão, R.A.C. ; Pinho, V.D. ; Coelho, A.S. ; Kümmerle, A.E. ; Costa, P.R.R . New palladacycle-derived acylhydrazones as pre-catalysts in mirozoki-heck coupling and oxyarylations. Anais da academia brasileira de ciências (online), v. 90, p. 1273-1278, 2018.
Doi:10.1590/0001-3765201820170858
Costa, P.R.R; Bernardo, P. S. ; Guimaraes, G. H. C. ; Costas, F. C. F. ; Lopes, G. P. F. ; Netto, C. D. ; Maia, R. C. Pterocarpanquinone lqb-118 induces apoptosis mediated by akt and erk pathways in glioblastoma cells. Clinical cancer research , v. 24, p. 88-88-88, 2018.
Doi:10.1097/CAD.0b013e3283592da8
Faiões, V.S. ; Frota, L.C. R. M. ; Junior, E.F.C. ; Barcellos, J.C. F. ; Silva, T. ; Netto, C.D. ; Silva, S.A.G. ; Silva, A.J. M. ; Costa, P.R. R. ; Santos, E.C.T. Second-generation pterocarpanquinones: synthesis and antileishmanial activity. Journal of venomous animals and toxins including tropical diseases, v. 24, p. 35, 2018.
Doi: 10.1186/s40409-018-0174-7
Mendes, J.A. ; Salustiano, E.J. ; Pires, C.S. ; Oliveira, T. ; Barcellos, J.C.F. ; Cifuentes, J.M.C. ; Costa, P.R.R ; Rennó, M.N. ; Buarque, C.D . 11a- n -tosyl-5-carbapterocarpans: synthesis, antineoplastic evaluation and in silico prediction of admetox properties. Bioorganic chemistry, v. 80, p. 585-590, 2018.
Posso, S.V. ; Quesnot, N. ; Moraes, J.A.; Gitirana, L.B.; Feitosa, E.K. ; Barroso, M.V. ; Porto, L.C. ; Lanzetti, M. ; Valença, S.S . At-rvd1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by nrf2/keap1 pathway. International immunopharmacology, v. 56, p. 330-338, 2018.
Doi:10.1016/j.intimp.2018.01.045
Alves, D.R.F. ; Monteiro, H.A.V. ; Piranda, D.N. ; Leite,M.S. ; Silva, T.S.L. ; Bergmann,A. ; Valença, S.S. ; Perini, J.A. ; Jorge, R.V . Ptgs2 polymorphism rs689466 favors breast cancer recurrence in obese patients. Endocrine-related cancer, v. 25, p. Erc-17-0374-365, 2018.
Melo, A.C. ; Cavalieri,I.C. ; Barroso, M.V. ; Quesnot, N. ; Gitirana, L.B.; Lanzetti, M. ; Valença, S.S . Atorvastatin dose-dependently promotes mouse lung repair after emphysema induced by elastase. Biomedicine & pharmacotherapy, v. 102, p. 160-168, 2018.
Doi: 10.1016/j.biopha.2018.03.067
Quesnot, N. ; Bucher, S. ; Gade,C. ; Vlach, M.; Vene, E. ; Valença,S.S. ; Gicquel, T. ; Holst, H. ; Robin, M.A.; Loyer, P . Production of chlorzoxazone glucuronides via cytochrome p4502e1 dependent and independent pathways in human hepatocytes. Archives of toxicology, v. 92, p. 3077-3091, 2018.
2019
Silva, J.S. ; Sun,X. ; Ahmad, S. ; Wang, H. ; Sudo, R.T. ; Varagic,J. ; Ferrario, C.M. ; Sudo, G.Z. ; Groban, L . G-Protein-Coupled-Estrogen agonist g1 improves diastolic function and attenuates cardiac ras activation in estrogen-deficient hypertensive rats. Journal of cardiovascular pharmacology , v. 1, p. 1, 2019.
Doi: 10.1097/fjc.0000000000000721
Felix, N.S. ; Mendonça,L. ; Braga, C.L. ; Silva, J.S. ; Samary, C.S. ; Vieira, J.B. ; Cruz, F. ; Rocha, N.N. ; Sudo, G.Z. ; Rocco, P.R.M. ; Silva, P.L. Effects of infigratinib, new fibroblast growth factor receptor-1 inhibitor, with or without sildenafil in experimental pulmonary arterial hypertension. British journal of pharmacology , v. 1, p. `1, 2019.
Alves, B.E.O. ; Alencar, A.K.N. ; Gamba, L.E.R. ; Trachez, M.M.. ; Silva, J.S. ; Araújo, J.S.C. ; Montagnoli, T.L. ; Mendes, L.V.P. ; Coelho, P.M.P. ; Cunha, V.M.N. ; Otero, R.M.; Oliveira, G.M.M. ; Lima, L.M. ; Barreiro, E.J. ; sudo, roberto t. ; Sudo, G.Z . Reduction of cardiac and renal dysfunction by new inhibitor of dpp4 in diabetic rats. Pharmacological reports , v. 1, p. 1, 2019.
Doi:10.1016/j.pharep.2019.07.005
Barbosa, J. N. ; Hernandez, R. A.; Barros, E.O. ; Branco, L. A. C. ; Feijo, P. R. O. ; Romeiro, L. A. S. ; Nasciutti, L. E. ; Noël, F.G. ; Sainz, J. A.G.; Silva, C. L. M. The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by egf receptor inhibition. Life sciences , v. 239, p. 117048, 2019.
Doi: 10.1016/j.lfs.2019.117048
Dias, F.C. ; Alves, V.S. ; Matias, D.O. ; Figueiredo, C.P. ; Miranda, A.L.P. ; Passos, G.F. ; Costa, R . The selective trpv4 channel antagonist hc-067047 attenuates mechanical allodynia in diabetic mice. European journal of pharmacology, v. 856, p. 172408, 2019.
Doi: 10.1016/j.ejphar.2019.172408
Silva, R. C. ; Veiga, F. ; Vilela, F.C. ; Pereira, A.V. ; Cunha,T.T.S, ; Tesch, R ; Viegas, C. ; Dias, D.F. ; Giusti-paiva, Alexandre ; Veloso, M.P.; Fraga, C.A.M . Design, synthesis and pharmacological evaluation of novel anti-inflammatory and analgesic o-benzyloxime compounds derived from natural eugenol. Letters in drug design & discovery, v. 15, p. 1157-1166, 2019.
Doi : 10.2174/1570180815666180620145609
Silva, R.R ; Silva, L. T. P. ; Pompeu, T. E.T. ; Duarte, D.A. ; Fraga, C. A.M. ; Barreiro, E. J. ; Menegatti, R; Costa-neto,C. M. ; Noël, F . Evaluation of functional selectivity of haloperidol, clozapine, and lassbio-579, an experimental compound with antipsychotic-like actions in rodents, at g protein and arrestin signaling downstream of the dopamine d2 receptor. Frontiers in pharmacology, v. 10, p. 628, 2019.
Rodrigues, D.A. ; Sagrillo, F.S . ; Fraga, C.A. M. Duvelisib: a 2018 novel fda-approved small molecule inhibiting phosphoinositide 3-kinases. Pharmaceuticals, v. 12, p. 69, 2019.
Monteiro, C.E.S. ; Franco, A.X. ; Sousa, J.A.O. ; Matos, V.E.A. ; Souza, E.P. ; Fraga, C.A.M.; Barreiro, E.J. ; Souza, M.H.L.P. ; Soares, P.M.G. ; Barbosa, A.L.R . Gastroprotective effects of n-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the no/cgmp/katp pathway. Biochemical pharmacology, v. 169, p. 113629, 2019.
Doi: 10.1016/j.bcp.2019.113629
Pinheiro, P.S. M.; Rodrigues, D.A. ; Maia, R. C. ; Thota, S ; Fraga, C. A. M. The use of conformational restriction in medicinal chemistry. Current topics in medicinal chemistry, v. 19, p. 1712-1733, 2019.
Doi: 10.2174/1568026619666190712205025
Fraga, C.A.M. Strategies and tactics in medicinal chemistry. Current topics in medicinal chemistry, v. 19, p. 1677-1678, 2019.
Doi : 10.2174/156802661919191021122941
Predes, D. ; Oliveira, L. F. S. ; Ferreira, L. S. S. ; Maia, L.A.. ; Delou, J.M. A. ; Faletti, A ; Oliveira, I. ; Amado, N.G. ; Reis, A.H. ; Fraga, C.A. M. ; Kuster, R. ; Mendes, F.A. ; Borges, H. l. ; Abreu, J.G. The chalcone lonchocarpin inhibits wnt/β-catenin signaling and suppresses colorectal cancer proliferation. Cancers, v. 11, p. 1968, 2019.
Oliveira, S. D. S. ; Chen,J. ; Castellon, M. ; Mao, M. ; Raj,J. U. ; Comhair, S. ; Erzurum, S. ; Silva, C.L.M ; Machado, R. F. ; Bonini, M. G. ; Minshall, R. Injury-induced shedding of extracellular vesicles depletes endothelial cells of cav-1 (caveolin-1) and enables tgf-β (transforming growth factor-β)-dependent pulmonary arterial hypertension. Arteriosclerosis thrombosis and vascular biology , v. 39, p. 1, 2019.
Doi:10.1161/atvbaha.118.312038
Chaves, M. M. ; Sinflorio, D. A. ; Thorstenberg, M. L. ; Martins, M. D. A. ; Souza, A. C. A.M. ; Rangel, T. P. ; Silva, C.L.M. ; Bellio, M. ; Canetti, C. ; Silva, R.C. Non-canonical nlrp3 inflammasome activation and il-1β signaling are necessary to l. Amazonensis control mediated by p2x7 receptor and leukotriene b4. Plos pathogens , v. 15, p. E1007887, 2019.
Doi:10.1371/journal.ppat.1007887
Quaresma, B.M.C.S. ; Pimenta, A.R. ; Silva, A.C.S ; Pupo, A.S. ; Romeiro, L.A.S. ; Silva, C.L.M ; Noel, F.G . Revisiting the pharmacodynamics uroselectivity of alpha1-adrenergic receptor antagonists. Journal of pharmacology and experimental therapeutics , v. 270, p. Jpet.119.260216, 2019.
Amaral, D.N.; Lategahn,J. ; Fokoue, H.H. ; Silva, E.M.B. ; Sant’anna, C.M.R. ; Rauh, D. ; Barreiro, E.J.. ; Laufer, S. ; Lima, L.M . A novel scaffold for egfr inhibition: introducing n-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives. Scientific reports , v. 9, p. 1-12, 2019.
Doi:10.1038/s41598-018-36846-7
Queiroz, A.C. ; Alves, M.A. ; Barreiro, E.J. ; Lima, L.M. ; Moreira, M.S.A . Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis. Experimental parasitology , v. 201, p. 57-66, 2019.
Doi:10.1016/j.exppara.2019.04.003
Barreiro, E.J. What is hidden in the biodiversity? The role of natural products and medicinal chemistry in the drug discovery process. Anais da academia brasileira de ciências (online) , v. 91, p. E20190306-e20190306, 2019.
Doi:10.1590/0001-3765201920190306
Camaforte, N.A. P. ; Saldanha, L.L. ; Vareda, P. M. P. ; Neto, J.M.R. ; Senger, M.R. ; Delgado, A.Q.; Morgan, H. J. N. ; Violato, N. M. ; Pieroni, L.G. ; Dokkedal, A.L. ; Júnior, F.P.S. ; Bosqueiro, J.R. Hypoglycaemic activity of bauhinia holophylla through gsk3-β inhibition and glycogenesis activation. Pharmaceutical biology , v. 57, p. 269-279, 2019.
Doi: 10.1080/13880209.2019.1599962
Merigueti, T. ; Carneiro, M. W. ; Assef, A. P. D. C. ; Júnior, F.P.S. ; Silva, F. A. B. Findtargetsweb: a user-friendly tool for identification of potential therapeutic targets in metabolic networks of bacteria. Frontiers in genetics , v. 10, p. 1-14, 2019.
Pereyra, C.E. ; Dantas, R.F. ; Ferreira, S.B. ; Gomes, L.P. ; Júnior, F.PS. The diverse mechanisms and anticancer potential of naphthoquinones. Cancer cell international , v. 19, p. 1-20, 2019.
Dantas, R.F. ; Senger, M.R. ; Cardoso, M.F. C. ; Ferreira, V.F. ; Souza, M.C. B. V. ; Silva, F.C. ; Jùnior, F.P.S. Screening of 1,2-furanonaphthoquinones 1,2,3-1h-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity. Medicinal chemistry research , v. 28, p. 1579-1588, 2019.
Doi:10.1007/s00044-019-02396-4
Dantas, R.F. ; Evangelista, T.C.S. ; Neves, B.J. ; Senger, M.R. ; Andrade, C.H. ; Ferreira, S.B. ; Junior, F.P.S . Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings. Expert opinion on drug discovery , p. 1-14, 2019.
Doi: 10.1080/17460441.2019.1654453
Torres, P.H. M. ; Sodero, A.C. R. ; Jofily, P. ; Jùnior, F.P.S. Key topics in molecular docking for drug design. International journal of molecular sciences , v. 20, p. 4574, 2019.
Lopes, J.P.B. ; Silva, L. ; Ceschi, M.A. ; Lüdtke, D.S. ; Zimmer, A.R. ; Ruaro, T.C. ; Dantas, R.F. ; Salles, C.M.C. ; Júnior, F.P.S. ; Senger,M.R. ; Barbosa, G. ; Lima, L.M. ; Guedes, I.A. ; Dardenne, L.E . Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. Medchemcomm , p. 99, 2019.
Neves, G.; Grace, A. A. Α7 nicotinic receptor full agonist reverse basolateral amygdala hyperactivity and attenuation of dopaminergic neuron activity in rats exposed to chronic mild stress. European neuropsychopharmacology , v. 10/12, p. 1, 2019.
Doi: 10.1016/j.euroneuro.2019.09.009
Monteiro, J. ; Lemos, G.A. ; Ferreira, E.S. ; Marques, A. M. ; Neves, G. ; Silveira, M. S. ; Galina, A. Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. Journal of bioenergetics and biomembranes , v. 1, p. 1, 2019.
Doi: 10.1007/s10863-019-09816-5
Akuthota, P. ; Neves, J.S. ; Ueki, S . Editorial: severe eosinophilic disorders: mechanisms and clinical management. Frontiers in immunology , v. 10, 2019.
Neto, F.M. ; Matos, M.S. ; Costa, A.C.R. ; Reis, R.A.M. ; Atella, G.C. ; Alves, L.M. ; Carvalho, D.P. ; Ketzer, L.A. ; Costa, V.M.C . Brown adipose tissue remodeling induced by corticosterone in wistar male rats. Experimental physiology , v. 104, p. 514-528, 2019.
Portovedo, S. ; Gaido, N. ; Nunes, B. ; Nascimento, A. G. ; Rocha, A. ; Magalhaes, M. ; Nascimento, G. ; Carvalho, D.P. ; Soares, P. ; Takiya, C. ; Faria, M. S. ; Alves, L.M . Differential expression of hmga1 and hmga2 in pituitary neuroendocrine tumors. Molecular and cellular endocrinology , v. 19, p. 30110-30118, 2019.
Silva, M.M. ; Gonçalves, C.F.L. ; Alves, L.M. ; Fortunato, R.S. ; Carvalho, D.P. ; Ferreira, A.C.F . Inhibition of type 1 iodothyronine deiodinase by bisphenol a. Hormone and metabolic research , v. 51, p. 671-677, 2019.
Costa, C. S. ; Alves, L.M. ; Merrill, M. A. L. ; Silva, L. V. ; Graceli, J. B. The tributyltin leads to obesogenic mammary gland abnormalities in adult female rats. Toxicology letters , v. 307, p. 59-71, 2019.
Doi: 10.1016/j.toxlet.2019.02.016
Lima, L.M.; Alves, M.A. ; Amaral, D.N . Homologation: a versatile molecular modification strategy to drug discovery. Current topics in medicinal chemistry , v. 19, p. 1-17, 2019.
Doi : 10.2174/1568026619666190808145235
Gonsalez, S.R. ; Cortês, A.L. ; Silva, R.C. ; Lowe,J. ; Prieto, M.C. ; Lara, L.S . Acute kidney injury overview: from basic findings to new prevention and therapy strategies. Pharmacology & therapeutics , v. 200, p. 1-12, 2019.
Doi: 10.1016/j.pharmthera.2019.04.001
Pereira, D. G. ; Rendeiro, M. M. ; Cortes, V. F. ; Barbosa, L.A. ; Quintas, L. E. M. . Antagonistic anticancer effect of paclitaxel and digoxin combination. Journal of cellular biochemistry , v. 1, p. 1, 2019.
Carvalho, D. C. M. ; Silva, L. H. C. ; Lima, E. A. ; Galvao, J. ; Alves, A. ; Feijo, P.R. ; Quintas, L. E. M. ; Mascarenhas, S. . Marinobufagenin inhibits neutrophil migration and proinflammatory cytokines. Journal of immunology research , v. 2019, p. 1-11, 2019.
Bastos, U. M. C. ; Rosa, I. A. ; Teixeira, J. D. ; Santos, G. G. ; Costa, M. L. ; Quintas, L. E. M. ; Mermelstein, C. Isoproterenol induces an increase in muscle fiber size by the proliferation of pax7 positive cells and in a mtor independent mechanism. Cell biology international , v. 1, p. 1-10, 2019.
Chater, J.M. ; Mathon, C. ; Larive, C.K. ; Merhaut, D.J. ; Tinoco, L.W. ; Mauk, P.A. ; Jia, Z. ; Preece, J.E. Juice quality traits, potassium content, and 1h nmr derived metabolites of 14 pomegranate cultivars. Journal of berry research, v. 9, p. 1-17, 2019.
Nirma, C.; Rangel, G.T. ; Alves, M.A. ; Casanova,L.M. ; Moreira, M.M. ; Rodrigues, L.M.; Hamerski, L. ; Tinoco, L.W . New nucleoside hydrolase inhibitors from brazilian flora. Rsc advances , v. 9, p. 18663-18669, 2019.
Figueiredo, C. P. ; Aragao, F. G. Q.B. ; Neris, R. L. S. ; Frost, P. S. ; Mello, C. S. P. S. ; Souza, I. N. O. ; Zeidler, J. D. ; Zamberlan, D. C. ; Sousa, V. L. ; Souza, A. S. ; Guimaraes, A. L. A. ; Bellio, M. ; Souza, J. M. ; Leon, S. V.A. ; Neves, G.A. ; Neto, H. A.P. ; Castro,N.G.; Felice, F. G. ; Miranda, I.A. ; Clarke, J. R. ; Poian, A. T. ; Ferreira, S. T. Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nature communications, v. 10, p. 3890, 2019.
Doi:10.1038/s41467-019-11866-7
Menezes, A. C. ; Reis, G. H. ; Nunes, M. C.O. ; Mariath, F. ; Cabanel, M. ;Pontes, B. ; Castro, N. G. ; Neto, J. M.B. ; Carneiro, K. Live cell imaging supports a key role for histone deacetylase as a molecular target during glioblastoma malignancy downgrade through tumor competence modulation. Journal of oncology, v. 2019, p. 1-16, 2019.
Freitas, C.S. Higa, L.M. Sacramento, C.Q. Ferreira, A.C. Reis,P.A. Delvecchio, R.M., Fabio , L. Lima, G.J.W.B., Vieira, Y.R.M.H., Rocha, N.H.M., Leme, R.P.P.B.L.V.B., Mônica M. L. Rodrigues, G.O.M. Lopes, C.E.Q.J. Lima,C.M. Costa, V.V. Teixeira, M.M.. Bozza, F.A.. Bozza, P.T. Boechat, N.T. Amilcar. Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo. Plos neglected tropical diseases , v. 13, p. E0007072, 2019.
Doi:10.1371/journal.pntd.0007072
Silva, R.M.R.J. ; Gandi,M.O. ; Mendonça,J.S. ; Carvalho,A.S. ; Coutinho,J.P.; Aguiar, A.C.C.; Krettli,A.U. ; Boechat,N . New hybrid trifluoromethylquinolines as antiplasmodium agents. Bioorganic & medicinal chemistry , v. 27, p. 1002-1008, 2019.
Doi: 10.1016/j.bmc.2019.01.044
Gonzaga, D. T. G. ; Oliveira, F. H. ; Salles, J. P. ; Bello, M. L. ; Rodrigues, C. R. ; Castro, H. C. ; Souza, H. ; Reis, C. ;Leme, R. ; Mafra, J. C. M. ; Pinheiro, L.C.S. ; Boechat, N. ; Faria, R. X. Synthesis, biological evaluation, and molecular modeling studies of new thiadiazole derivatives as potent p2x7 receptor inhibitors. Frontiers in chemistry , v. 7, p. 1-15, 2019.
45. Ferreira, A.C. ; Reis, P.A. ; Freitas, C.S. ; Sacramento, C.Q. ; Hoelz, L.V.B. ; Bastos, M.M. ; Mattos, M ; Rocha, N ; Quintanilha, I.G.A. ; Pedrosa, C.S.G. ; Souza, L.R.Q. ; Loiola, E.C. ; Trindade, P.; Vieira, Y.R. ; Lima, G.B. ; Neto,H.C.C.F.; Boechat,N. ; Rehen,S.K. ; Brüning,K.; Bozza,F.A. ; Bozza,P.T. ; Souza,T.M.L. Beyond members of the flaviviridae family, sofosbuvir also inhibits chikungunya virus replication. Antimicrobial agents and chemotherapy (online) , v. 63, p. E01389-18, 2019.
Venâncio, T.; Oliveira,L.M.; Pawlak, T.; Ellena, J.; Boechat,N. ; Brown,S.P. The use of variable temperature 13 c solid-state mas nmr and gipaw dft calculations to explore the dynamics of diethylcarbamazine citrate. Magnetic resonance in chemistry , v. 57, p. 200-208, 2019.
Lima,D.A.; Andreotti, C.E.A.; Ferreira, F.A. ; Pauli,K.B.; Silva,G.R.; Ribeiro,R.C.L. ; Dalsenter,P.R.; Boechat,N. ; Junior, G.A. ; Lourenço,E.L.B.; Lívero,F.A.R. Safety assessment of mefas: an innovative hybrid salt of mefloquine and artesunate for malaria treatment. Drug and chemical toxicology , v. 42, p. 1-6, 2019.
Doi: 10.1080/01480545.2019.1607371
Feitosa,L.M. ; Silva,E.R. ; Hoelz,L.V.B.; Souza,D.L. ; Come, J.A.A.S.S.; Santos, C.C. ; Batista,M.M. ; Soeiro,M.N.C. ; Boechat,N. ; Pinheiro,L.C.S. New pyrazolopyrimidine derivatives as leishmania amazonensis arginase inhibitors. Bioorganic & medicinal chemistry, v. 27, p. 3061-3069, 2019.
Doi: 10.1016/j.bmc.2019.05.026
Silva, M. R.S. ; Araújo, J. S. ; Peres, R. B. ; Silva, P. B. ; Batista, M. M. ; Azevedo, L. D. ; Bastos, M. M. ; Bahia, M. T. ; Boechat, N. ; Soeiro, M. N. C. Repurposing strategies for chagas disease therapy: the effect of imatinib and derivatives against trypanosoma cruzi. Parasitology , v. 146, p. 1-7, 2019.
Doi: 10.1017/s0031182019000234.
Trompowsky, A.C.M.V. ; Conde, T.R. ; Lemos, R.C. ; Quaresma, B.M.C.S ; Pitombeira, M.C.R.S. ; Carvalho, A.S. ; Boechat, N. ; Salomão,K ; Castro, S.L. ; Zamith, H.P.S . In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents. Memórias do instituto oswaldo cruz , v. 114, p. 1-10, 2019.
Pinheiro, L.C.S ; Ferreira, M.L.G. ; Silveira, F.F. ; Feitosa, L.M. ; Boechat, N . Synthetic compounds with sulfonamide moiety against leishmaniasis: an overview. Medicinal chemistry research , v. 28, p. 1807-1817, 2019.
Doi:10.1007/s00044-019-02432-3
Lima, E.C. ; Castelo-branco, F.S. ; Maquiaveli, C.C. ; Farias, A.B. ; Rennó, M.N. ; Boechat, N. ; Silva, E.R. Phenylhydrazides as inhibitors of leishmania amazonensis arginase and antileishmanial activity. Bioorganic & medicinal chemistry, v. 27, p. 3853-3859, 2019.
C. S. Pinheiro, luiz ; Lívia, M.F. ; Gandi, M.O. ; Silveira, F.F. ; Boechat, N. The development of novel compounds against malaria: quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines. Molecules , v. 24, p. 4095, 2019.
Vale, C.M.F. ; Quaresma, B.M.S ; Pitombeira, M.C.R. ; Brito, M.A. ; Farias, P.P.; Castro, S.L. ; Salomão, K. Carvalho, A.S. ; Paula, J.I.O. ; Nascimento, S.B. ; Cupello, M.P. ; Paes, M.C.; Boechat, N. ; Felzenszwalb, I . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European journal of medicinal chemistry , v. 2019, p. 111887-111902, 2019.
Doi: 10.1016/j.ejmech.2019.111887.
Boechat, núbia a; magalhães j.l. ; zulmira hartz ; marlede menezes ; mendonça, jorge s. An overview of antibiotics in brazil:a sovereign been lost of the amoxicillin. Chimica oggi-chemistry today , v. 37, p. 73, 2019.
Trompowsky, A.C.M.V. ; Conde, T.R. ; Lemos, R.C. ; Quaresma, B.M.C.S ; Pitombeira, M.C.R.S. ; Carvalho, A.S. ; Boechat, N. ; Salomão,K ; Castro, S.L. ; Zamith, H.P.S . In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents. Memórias do instituto oswaldo cruz , v. 114, p. 1-10, 2019.
Soares, S.S. ; Bekbolatova,E. ; Cotrim, M.D. ; Sakipova, Z. ; Ibragimova, L.; Koch,W.K. ; Giorno, T.B.S. ; Fernandes, P.D. ; Fonseca, D.A. ; Boylan, F. Chemistry and pharmacology of the kazakh crataegus almaatensis pojark: an asian herbal medicine. Antioxidants, v. 8, p. 300, 2019.
Giorno, T.B.S. ; Santos, C.H.C. ; Carvalho, M.G. ; Silva, V.C. ; Sousa, P.T. ; Fernandes, P.D. ; Boylan,F . Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (cogn.) Baill. Molecules , v. 24, p. 4584, 2019.
Doi: 10.3390/molecules24244584
Strauch, M.A. ; Tomaz, M.A. ; Machado, M.M. ; Cons, B.L.; Neto, F.C.P. ; Cruz, J.M.T. ; Henriques, M.S.T. ; Souza, P.D.N. ; Gomes, S.L.S. ; Costa, P.R.R. ; Schaeffer, E. ; Silva, A.J. M. ; Melo, P.A . Lapachol and synthetic derivatives: in vitro and in vivo activities against bothrops snake venoms. Plos one , v. 14, p. E0211229-18, 2019.
Doi: 10.1371/journal.pone.0211229.
Telles, T. S. ; Silva,P.M. ; Martins, M.A. ; Carvalho, V. Glucocorticoids decrease the numbers and activation of mast cells by inducing the transactivation receptors of ages. Journal of leukocyte biology, v. 2018, p. 1-12, 2019.
Rumjanek, V. M ; Maia, R.C. ; Salustiano, E.J. ; Costa, P.R.R . Insights into the biological evaluation of pterocarpanquinones and carbapterocarpans with anti-tumor activity against mdr leukemias. Anti-cancer agents in medicinal chemistry , v. 18, 2019.
Doi: 10.2174/1871520618666180420165128
Mendes, J.A. ; Merino, P. ; Soler, T.; Salustiano, E.J. ; Costa, P.R. R. ; Yus, M. ; Foubelo, F. ; Buarque, C.D. Enantioselective synthesis, dft calculations, and preliminary antineoplastic activity of dibenzo 1-azaspiro[4.5]decanes on drug-resistant leukemias. Journal of organic chemistry, v. 84, p. 2219-2233, 2019.
Souza, L.G. ; Domingos, J.L.O. ; Fernandes, T.A. ; Renno, M.N. ; Sansano, J.M. ; Najera, C. ; Costa, P.R.R . Enantioselective electrophilic fluorination of α-aryl-tetralones using a preparation of n-fluoroammonium salts of cinchonine. Journal of fluorine chemistry , v. 217, p. 72-79, 2019.
Doi:10.1016/j.jfluchem.2018.11.007
Feitosa, E.K. ; Cavalieri, I.C. ; Barroso, M.V. ; Souza, B.R. ; Gitirana, L.B. ; Valenca, S.S . Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema. Phytomedicine, v. 55, p. 70-79, 2019.
Doi:10.1016/j.phymed.2018.08.012
Cavalieri, I.C.; Valenca, S.S. ; Lanzetti,M. ; Carvalho, G.M.C. ; Zin, W.A. ; Costa, A.M.A. ; Porto, L.C. ; Souza, B.R . Acute exposure to diesel-biodiesel particulate matter promotes murine lung oxidative stress by nrf2/ho-1 and inflammation through the nf-kb/tnf-α pathways. Inflammation, v. 42, p. 526-537, 2019.
Barroso, M.V. ; Reis, A.G. ; Cavalieri, I.C. ; Gitirana, L.B. ; Valenca, S.S.; Lanzetti, M . Mate tea reduces high fat diet-induced liver and metabolic disorders in mice. Biomedicine & pharmacotherapy, v. 109, p. 1547-1555, 2019.
Doi:10.1016/j.biopha.2018.11.007
Zuo, H. ; Cavalieri , I.C.P.; Valença, S.S. ; Musheshe, N. ; Schmidt , M. Function of cyclic amp scaffolds in obstructive lung disease: focus on epithelial-to-mesenchymal transition and oxidative stress. British journal of pharmacology, v. 176, p. 2402-2415, 2019.
Vasconcelos, F.M. ; Silva, H.L.A. ; Poso, S.M.V. ; Barroso, M.V. ; Lanzetti, M. ; Rocha, R.S.; Graça, J.S. ;Esmerino, E.A. ; Freitas, M.Q. ; Silva, M.C. ; Raices, R.S.L. ; Granato, D. ; Pimentel, T.C. ; Sant'ana, A.S. ; Cruz, A.G. ; Valença, S.S. Probiotic prato cheese attenuates cigarette smoke-induced injuries in mice. Food research international, v. 123, p. 697-703, 2019.
Doi: 10.1016/j.foodres.2019.06.001
2018
Rodrigues, D.A ; Pinheiro, P. S.M. ; Ferreira, T. T. S. C. ; Thota, S. ; Fraga, C. A. M. Structural basis for the agonist action at free fatty acid receptor 1 (ffa1r or gpr40). Chemical biology & drug design, v. 91, p. 668-680, 2018.
Freitas, R.H. C. N. ; Cordeiro, N.M. ; Carvalho, P.R. ; Alves, M.A. ; Guedes, I.A. ; Valerio, T.S. ; Dardenne, L.E.. ; Lima,L. M. ; Barreiro, E.J. ; Fernandes, P.D.. ; Fraga, C.A. M. Discovery of naphthyl- n -acylhydrazone p38α mapk inhibitors with in vivo anti-inflammatory and anti-tnf-α activity. Chemical biology & drug design , v. 91, p. 391-397, 2018.
Freitas, R.H.C.N.; Fraga, C.A.M. Nf-κb-ikkβ pathway as a target for drug development: realities, challenges and perspectives. Current drug targets , v. 19, p. 1933-1942, 2018.
Doi: 10.2174/1389450119666180219120534
Osorio, L.F. B. ; Carvalho, S.A. ; Silva, E.F. D. ; Fraga, C.A. M. ; Wardell, S.M. S. V. ; Milne, B.F. ; Wardell,J. l. ; Harrison,W.T. A. Different molecular conformations in the crystal structures of three 5-nitroimidazolyl derivatives. Acta crystallographica section e, crystallographic communications, v. 74, p. 380-384, 2018.
Doi: 10.1107/s2056989018002876
Costa, F.B. ; Cortez, A.P. ; Ávila,R. I. ;Carvalho, F.S. ; Andrade, W.M. ; Cruz, A.F. ; Reis, K.B. ; Menegatti, R. ; Lião,L.M. ; Romeiro, L.A.S. ;F. ; C.A.M. ; Barreiro, E.J; Sanz, G.; Rodrigues, M.F. ; Vaz, B.G. ; Valadares, M.C . The novel piperazine-containing compound lqfm018: necroptosis cell death mechanisms, dopamine d 4 receptor binding and toxicological assessment. Biomedicine & pharmacotherapy , v. 102, p. 481-493, 2018.
Doi: 10.1016/j.biopha.2018.02.120
Alencar, A.K. ; Carvalho, F.I. ; Silva, A.M. ; Martinez, S.T. ; Calasans-maia, J.A. ; Fraga, C.A.M ; Barreiro, E.J. ; Sudo, G.Z. ; Sudo, R.T. Synergistic interaction between a pde5 inhibitor (sildenafil) and a new adenosine a2a receptor agonist (lassbio-1359) improves pulmonary hypertension in rats. Plos one , v. 13, p. E0195047, 2018.
Doi:10.1371/journal.pone.0195047
Tesch, R ; Recker, C ; Müller, M.P. ; Beck,M.E.; Quambusch, L. ; Getlik, M ; Lategahn, J. ; Uhlenbrock, N; Costa,F.N.; Polêto,M.D. ; Pinheiro, P.S.M. ; Rodrigues,D.A.; Sant’anna, C. M.; Ferreira, F.F. ; Verli, H. ; Fraga,C.A.M.; Rauh, D . An unusual intramolecular halogen bond guides conformational selection. Angewandte chemie-international edition , v. 57, p. 9970-9975, 2018.
Alencar,A.K.N.; Montes,G.C.; Costa,D.G.; Mendes,L.V.P.; silva, Ananssa, M. S. ; Martinez,S.T.; Trachez, M.M. ; Cunha,V.M.N.; Montagnoli,T.I.; Fraga, A.G.M. ; Wang, H.; Groban, L; Fraga,C.A.M.; Sudo, R.T. ; Sudo, G.Z. Cardioprotection induced by activation of gper in ovariectomized rats with pulmonary hypertension. Journals of gerontology series a-biological sciences and medical sciences , v. 73, p. 1158-1166, 2018.
Thota, S; Rodrigues,D.A. ; Pinheiro, P.S.M.; Lima,L.M. ; Fraga, C.A.M. ; Barreiro,E.J. N -acylhydrazones as drugs. Bioorganic & medicinal chemistry letters , v. 28, p. 2797-2806, 2018.
OliveiraR.G.; Guerra, F.S. ; Mermelstein, C.S. ; Fernandes, P.D. ; Bastos,I.T.S.; Costa,F.N.; Barroso, R.C.S. ; Ferreira,F.F.; Fraga, C.A.M. Synthesis and pharmacological evaluation of novel isoquinoline n -sulphonylhydrazones designed as rock inhibitors. Journal of enzyme inhibition and medicinal chemistry , v. 33, p. 1181-1193, 2018.
Doi:10.1080/14756366.2018.1490732
Pinheiro,P.S.M.; Rodrigues, D.A. ; Sant'anna,C.M.R.. ; Fraga, C.A.M. Modeling zinc-oxygen coordination in histone deacetylase: a comparison of semiempirical methods performance. International journal of quantum chemistry , v. 118, p. E25720, 2018.
Bastos, I.; Pinheiro, P. ; Costa, F. ; Rocha, M; Sant’anna, C.M.R. ; Braz,D. ; Souza, E. ; Martins, M. ; Barreiro, E.J.; Ferreira,F. ; Barroso, R. ; Fraga, C.A.M. Design, synthesis, experimental and theoretical characterization of a new multitarget 2-thienyl-n-acylhydrazone derivative. Pharmaceuticals, v. 11, p. 119, 2018.
Oliveira,V.R. ; Carvalho, G.M.C. ; Casquilho,N.V.; Gomes, M.D.M. ; Soares,R.M.; Azevedo,S.M.F.O. ; Lima,L.M.; Barreiro, E.J. ; Takiya, C.M. ; Zin, W.A . Lung and liver responses to 1- and 7-day treatments with lassbio-596 in mice subchronically intoxicated by microcystin-lr. Toxicon , v. 141, p. 1-8, 2018.
Doi:10.1016/j.toxicon.2017.10.029
Thota, S. ; Rodrigues, D.A. ; Crans, D.C. ; Barreiro, E.J. Ru(ii) compounds: next-generation anticancer metallotherapeutics?. Journal of medicinal chemistry , v. 46, p. 000-000, 2018.
Doi:10.1021/acs.jmedchem.7b01689
Casquilho, N.V. ; Gomes, M.D.M. ; Magalhães, C.B. ; Okuro,R.T. ; Ortenzi, V.H. ; Lima, E.K.F. ; lima, L.M. ; Barreiro, E.J. ; Soares,R.M. ; Azevedo, S.M.F.O. ; Valença,S.S. ; Fortunato, R.S. ; Carvalho, A.R. ; Zin, W.A. Oxidative imbalance in mice intoxicated by microcystin-lr can be minimized. Toxicon , v. 144, p. 75-82, 2018.
Doi:10.1016/j.toxicon.2018.02.008
Herrmann,S. ; Schübel,T.; Costa, F.N.. ; Barbosa, M.L.C. ; Ferreira, F.F. ; Dias, T.L.M.F. ; Araújo, M.V. ; Moreira, M.S.A. ; Lima, L.M. ; Laufer, S. ; Barreiro, E.J. Synthesis, x-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones. Anais da academia brasileira de ciencias , v. 90, p. 1073-1088, 2018.
Doi:10.1590/0001-3765201820170796
Amaral, D. N. ; Sant’anna, C.M.R. ; Cavalcanti, B. C. ; Pessoa C. O. ; Lima, L.M. ; Barreiro,E.J. Synthesis, pharmacological evaluation and docking study of a new. Letters in drug design and discovery, v. 15, p. 778-786, 2018.
Doi: 10.2174/1570180814666171012162557
Silva, J.C. ; Júnior, R.G.O. ; Silva, M.G. ; Lavor, E.M. ; Soares, J.M.D. ; Saraiva, S.R.G.L. ; Diniz, T.C. ; Mendes, R.L. ;Filho, E.B.A ; Barreiro, E.J. ; Lima, L.M. ; Almeida, J.R. G.S . Lassbio-1586, an n-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. Plos one , v. 13, p. E0199009, 2018.
Teixeira, M.A.C.; Belloze, K.T. ; Cavalcanti, M.C. ; Junior, F.P.S. Data mart construction based on semantic annotation of scientific articles: a case study for the prioritization of drug targets. Computer methods and programs in biomedicine , p. 225-235, 2018.
Doi:10.1016/j.cmpb.2018.01.010
Oliveira, A. ; Bleicher, L. ; Schrago, C.G. ; Junior, F.P.S . Conservation analysis and decomposition of residue correlation networks in the phospholipase a2 superfamily (pla2s): insights into the structure-function relationships of snake venom toxins. Toxicon , p. 50-60, 2018.
Doi: 10.1016/j.toxicon.2018.03.013
Lopes, J.P.B. ; Silva, L.; Franarin, G.C. ; Ceschi, M.A. ; Lüdtke, D.S. ; Dantas, R.F. ; Salles, C.M.C. ; Júnior, F.P.S. ; Senger, M.R. ; Guedes, I.A. ; Dardenne, L.E. Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives. Bioorganic & medicinal chemistry , v. 1, p. 1, 2018.
Doi: 10.1016/j.bmc.2018.10.003
Brito, A. ; Braga, P. ; Moreira, L. ; Silva, D. ; Silva, D. ; German, S. ; Gontijo, B. ; Carvalho, F. ; Liao, L. ; Silva, R. R. ; Noël, F.G. ; Neri, H. ; Ghedini, P. C. ; Carvalho, M. ; Gil, E. ; Costa, E. ; Menegatti, R. A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4- hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity. Naunyn-schmiedebergs archives of pharmacology , v. 391, p. 255-269, 2018.
Amaral, L. S. ; Ferreira, J. M. ; Predes, D. ; Abreu, J. G. ; Noel, F.G. ; Quintas, L. E. M. Telocinobufagin and marinobufagin produce different effects in llc-pk1 cells: a case of functional selectivity of bufadienolides. International journal of molecular sciences , v. 19, p. 2769, 2018.
Noël, F.G.; Azalim, P. ; Monte, F.M. ; Quintas, L. E. M. ; Katz, A. ; Karlish, S. J. Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on na+,k+-atpase (α1β1): methodological considerations. Journal of pharmacological and toxicological methods , v. 94, p. 64-72, 2018.
Doi: 10.1016/j.vascn.2018.09.001
Ahmad, S. ; Sun, X. ; Lin, M ; Varagic, J. ; Sudo, G.Z. ; Ferrario, C.M. ; Groban, L. ; Wang, H. Blunting of estrogen modulation of cardiac cellular chymase/ras activity and function in shr. Journal of cellular physiology , v. 233, p. 3330-3342, 2018.
Aguiar, R.P.S. ; Bezerra, N.C. F. ; Lucena, M.C. ; Sirtoli, G.M. ; Sudo, R.T. ; Sudo, G.Z. ; Takiya, C.M. ; Pinheiro, A.A.S. ; Dias, W.B. ; Neves, C.C . O -glcnacylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats. Journal of biological chemistry , v. 293, p. Jbc.ra118.0017-12749, 2018.
Sudo,R.T. ; Hayashida, K. ; Santos, A.N. ; Kawatani, M. ; Monteiro, C.E. ; Moreira, R.D. ; Trachez, M.M. ; Montes, G.C.; Sudo, G.Z. Novel agonist of α4β2* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain. Journal of pain research , v. Volume 11, p. 2453-2462, 2018.
Alencar, A.K. N. ; Coelho,P.M.P.; Montes, G.C. ; Silva, M.M.C. ; Mendes, L.V. P. ; Montagnoli, T.L. ; Silva, A.M. S. ; Vasques, J.F. ; Castro, P.H.R. ; Gutfilen, B. ; Cunha, V.M. N. ; Fraga, A.G. M. ; Silva, P.M.R. ; Martins, M.A. ; Ferreira, T.P.T. ; Otero, R.M. ; Trachez, M.M. ; Sudo, R.T. ; Sudo, G.Z . Human mesenchymal stem cell therapy reverses su5416/hypoxia-induced pulmonary arterial hypertension in mice. Frontiers in pharmacology , v. 9, p. 1-16, 2018.
Alencar, A.K.N. ; Silva, J.S. ; Lin, M. ; Silva. A.M.S. ; Sun, X. ; Ferrario, C. M. ; Cheng, C. ; Sudo, R.T. ; Sudo, G.Z. ; Wang, H. ; Groban, l. Effect of age, estrogen status, and late-life gper activation on cardiac structure and function in the fischer344×brown norway female rat. The journals of gerontology. Series a, biological sciences and medical sciences , v. 72, p. 152-162, 2017.
Wang, H. ; Sun, X. ; Chou,J. ; Lin, M. ; Ferrario, C.M. ; Sudo, G.Z.; Groban, L .Inflammatory and mitochondrial gene expression data in gper-deficient cardiomyocytes from male and female mice. Data in brief, v. 10, p. 465-473, 2017.
Montes, G. ; Silva, B. ; Rezende, B. ; Sudo,R.T. ; Ferreira, V. ; Silva, F.C. ; da Pinto, A.C. ; Silva, B. ; Sudo, G.Z . The hypnotic, anxiolytic, and antinociceptive profile of a novel µ-opioid agonist. Molecules , v. 22, p. 800, 2017.
Doi: 10.3390/molecules22050800
Viana, E.O.R. ; Cruz, M.F.S.J. ; Silva, M.J. ; Pereira, G.M. ; Silva, B.P. ; Tinoco, L.W ; Parente, J.P. Structural characterization of a complex triterpenoid saponin from albizia lebbeck and investigation of its permeability property and supramolecular interactions with membrane constituents. Carbohydrate research , v. 471, p. 105-114, 2018.
Doi:10.1016/j.carres.2018.11.015
Viegas, F. P. D. R.; Castelli, M. Silva, M.; Riquiel, M. M.; Machado, R. P. Vaz, S. M. ; Medeiros, L.; Mancini, K. C. ;Cruz, P. O.; Moraes, E. P. ;Silva, F. M. R.; Peçanha, D. D. F.; Castro, N. G. ; Neves, G. ; Paiva, A.V.G.; Orlandi, L.; Camps, I. ;Veloso, M. P. ; Coelho, L. F.; Ionta, M.L. Silva, G.F. A.; Pereira, R. M.; Dardenne, L. Design, synthesis and pharmacological evaluation of n -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: discovery of novel multi-target anti-alzheimer prototype drug candidates. European journal of medicinal chemistry , p. 48-65, 2018.
Doi:10.1016/j.ejmech.2018.01.066
Neves, G.; Grace, A. A. Α7 nicotinic receptor-modulating agents reverse the hyperdopaminergic tone in the mam model of schizophrenia. Neuropsychopharmacology , p. Apr 19 [epub], 2018.
Doi: 10.1038/s41386-018-0066-0
Souza, I. N. O. ; Frost, P. S. ; Franca, J. V. ; Viana, J.N. ; Neris, R. L. S. ; Freitas, L. ; Pinheiro, D. J. L. L. ; Nogueira, C. O. ; Neves, G. ; Chimelli, L. ; Felice, F. G. ; Cavalheiro, E. A. ; Ferreira, S. T. ; Miranda, I.A. ; Figueiredo, C. P. ; Poian, A. T. ; Clarke, J. H. R. Acute and chronic neurological consequences of early-life zika virus infection in mice. Science translational medicine , v. 10, p. Eaar2749, 2018.
Doi: 10.1126/scitranslmed.aar2749
Figueiredo, R.T. ; Neves, J.S. Eosinophils in fungal diseases: an overview. Journal of leukocyte biology , 2018.
Muniz, V.S. ; Silva, J.C. ; Braga, Y.A.V. ; Melo, R.C.N. ; Ueki, S. ; Takeda, M. ; Hebisawa, A. ; Asano, K. ; Figueiredo, R.T. ; Neves, J.S. Eosinophils release extracellular dna traps in response to aspergillus fumigatus. Journal of allergy and clinical immunology , v. 141, p. 571-585.e7, 2018.
Doi:10.1016/j.jaci.2017.07.048
Ueki, S. ; Hebisawa, A. ; Kitani,M. ; Asano, K. ; Neves, J.S. Allergic bronchopulmonary aspergillosis-a luminal hypereosinophilic disease with extracellular trap cell death. Frontiers in immunology , v. 9, 2018.
Silva, A. N. ; Dittz2, D. ; Santana, H. S. ; Faria, R. A. ; Freitas, K. M. ; Coutinho, C. R. ; Rodrigues, L. C. M. ; Alves, L.M. ; Silva, I. V. ; Graceli, J. B. ; Lima, L. C. F. The pollutant organotins leads to respiratory disease by inflammation: a mini-review. Frontiers in endocrinology , v. 8, p. 1-6, 2018.
Junior, B.C. ; Carvalho, D. P. ; Soares, P. ; Alves, L.M. Tributyltin and zebrafish: swimming in dangerous water. Frontiers in endocrinology , v. 9, p. 1-7, 2018.
Gonçalves, C.F.L. ; Freitas, M.L. ; Fortunato, R.S. ; Alves,L.M. ; Carvalho, D.P. ; Ferreira, A.C.F . Rutin scavenges reactive oxygen species, inactivates 5--adenosine monophosphate-activated protein kinase, and increases sodium-iodide symporter expression in thyroid pccl3 cells. Thyroid , v. 28, p. 265-275, 2018.
Andrade, M. N. ; Silva, A. P.S. ; Pereira,P.R. ; Melo, F. D.P. ; Junior, N. C. L. ; Teixeira, M. P. ; Soares, P. ; Dias, G. R. M. ; Graceli, J. B. ; Carvalho, D. P. ; Ferreira, A. C. F. ; Alves, L.M . The environmental contaminant tributyltin leads to abnormalities in different levels of the hypothalamus-pituitary-thyroid axis in female rats. Environmental pollution , v. 241, p. 636-645, 2018.
Doi: 10.1016/j.envpol.2018.06.006
Junior, C.B.; Silva, A. P. S. ; Ferreira, A. C. F. ; Graceli, J. B. ; Carvalho, D. P. ; Soares, P. ; Romeiro, N. C. ; Alves, L.M . Unraveling molecular targets of bisphenol a and s in the thyroid gland. Environmental science and pollution research , p. 1-11, 2018.
Araujo, J. F. ; Podratz, P. L. ; Sena, G. C. ; Merlo, E. ; Lima, L. C.F. ; Ayub, J. G. M. ; Pereira, A. F. Z. ; Silva, A. P. S.; Alves, L.M. ; Silva, I. V. ; Graceli, J. B. The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats. Toxicology letters , v. 295, p. 99-114, 2018.
Doi:10.1016/j.toxlet.2018.06.1068
Silva, M. M. ; Xavier, L. L. F. ; Goncalves, C. F. L. ; Silva, A. P.S. ; Melo, F. D. P. ; Freitas, M. L. ; Fortunato, R. S. ; Alves, L.M. ; Ferreira, A. C. F. Bisphenol a increases hydrogen peroxide generation by thyrocytes both in vivo and in vitro. Endocrine connections , p. 1196-1207, 2018.
Lopes, R.O. ; Alves, M.A. ; Pinheiro, R.O. ; Freitas, C.S. ; Cunha, F.Q. ; Barreiro, E.J. ; Lima, L.M . Synthesis, aqueous solubility, metabolic stability and pharmacological profile of simplified urea derivatives. Letters in drug design & discovery , v. 15, p. 766-777, 2018.
Doi: 10.2174/1570180814666171012155204
Paier, C.; Maranhão, S.S. ; Carneiro, T. ; Lima, L.M. ; Rocha, D.D. ; Santos, R.S. ; Farias, K.M. ; Filho, M.O.M. ; Pessoa, C . Natural products as new antimitotic compounds for anticancer drug development. Clinics , v. 73, p. E813s, 2018.
Doi:10.6061/clinics/2018/e813s
Gonsalez , S.R. ; , F. ; Souza, A. M. ; J ; Lara, L. S. Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis. Jornal Brasileiro de Nefrologia, v. 41, p. 1, 2018.
Doi:10.1590/2175-8239-jbn-3661
Marinho,P.C. ; Vieira, A.B. ; Pereira, P.G. ; Rabelo, K. ; Ciambarella, B.T. ; Nascimento, A. L.R. ; Cortez, E. ; Moura, A.S. ; Guimarães, F,V. ; Martins, M.A. ; Barquero, G. ; Ferreira, R.N. ; Carvalho, J.J. Capybara oil improves hepatic mitochondrial dysfunction, steatosis, and inflammation in a murine model of nonalcoholic fatty liver disease. Evidence-based complementary and alternative medicine , v. 2018, p. 1-9, 2018.
Carvalho, V.F. ; Barreto, E.O. ; Arantes, A.C.S. ; Serra, M.F. ; Ferreira, T.P.T. ; Sá, Y.A.J. P. ; Hogaboam, C.M. ; Martins, M.A. ; Silva, P.M. R. Diabetes downregulates allergen-induced airway inflammation in mice. Mediators of inflammation , v. 2018, p. 1-11, 2018.
Bastos, I. ; Pinheiro, P. ; Costa, F. ; Rocha,M. ; Sant’anna, C. ; Braz, D.; Souza, E. ; Martins, M.A. ; Barreiro, E.J. ; Ferreira, F. ; Barroso, R. ; Fraga, C. Design, synthesis, experimental and theoretical characterization of a new multitarget 2-thienyl-n-acylhydrazone derivative. Pharmaceuticals, v. 11, p. 119-14, 2018.
Serra, M.F. ; Cotias, A.C. ; Pão, C.R. R. ; Daleprane, J.B. ; Jurgilas, P.B. ; Couto, G.C. ; Valotta, E.A.A. ; Cordeiro, R.S. B. ; Carvalho, V.F. ; Silva, P.M. R. ; Martins, M.A. Repeated allergen exposure in a/j mice causes steroid-insensitive asthma via a defect in glucocorticoid receptor bioavailability. Journal of immunology , v. 201, p. Ji1700933-860, 2018.
Viegas, F.P.F.S.D., Rocha, M.C.M.D., Riquiel, M.M.M.M.R., Vaz, S.M.S.L.R.P., Mancini, L.M. Oliveira,K.C.M. Morais,P.C.;Gontijo,E.P.; Silva,V.S.; Motta,F.; Peçanha,D.F.; Castro, D.; Gonçalves, N.; Neves, G.A.; Paiva,G.; Vilela,A. Orlandi,F.C. Camps, L.; ihosvany veloso, Coelho,M.P.L. Ionta,L.F. Silva, M.F. Pereira,G.A. Machado ,R. Design, synthesis and pharmacological evaluation of n -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: discovery of novel multi-target anti-alzheimer prototype drug candidates. European journal of medicinal chemistry, v. 147, p. 48-65, 2018.
Doi:10.1016/j.ejmech.2018.01.066
Guimarães, M.Z. P. ; Vecchi, R.; Vitória, G.; Sochacki,J.K. ; Paulsen,B.S. ; Lima, I.; Silva, F.R. ; Costa, R.F. M. ; Castro,N.G. ; Breton, L.; Rehen,S.K. Generation of ipsc-derived human peripheral sensory neurons releasing substance p elicited by trpv1 agonists. Frontiers in molecular neuroscience, v. 11, p. 1-17, 2018.
Branco, F.S.C. ; Lima, E.C. ; Domingos, J.L.O.; Pinto, A.C. ; Lourenço, M.C.S. ; Gomes, K.M. ; Lima, M.M.C. ; Lima, C.F.A. ; Aiub, C.A.F. ; Felzenszwalb, I. ; Costa, T.E.M.M. ; Penido, C. ; Henriques, M.G. ; Boechat,N. . New hydrazides derivatives of isoniazid against mycobacterium tuberculosis: higher potency and lower hepatocytotoxicity. European journal of medicinal chemistry, v. 146, p. 529-540, 2018.
Doi: 10.1016/j.ejmech.2018.01.071
Leite, D.I. ; Fontes,F.V. ; Bastos, M.M. ; Hoelz, L.V.B. ; BiancoM.C.A.D. ; Oliveira, A.P. ; Silva, P.B. ; Silva, C.F. ; Batista, D.G.J. ; Gama, A.N.S. ; Peres, R.B. ; VillarJ.D.F. ; Soeiro, M.N.C.; Boechat, N. New 1,2,3-triazole-based analogues of benznidazole for use against trypanosoma cruzi infection: in vitro and in vivo evaluations. Chemical biology & drug design , v. 2018, p. 1-7, 2018.
Boechat, N.; Pinheiro, L.C.S. ; Feitosa, L. M. ; Silveira, F. F. Current antimalarial therapies and advances in the development of semi-synthetic artemisinin derivatives. Anais da academia brasileira de ciências (online) , v. 90, p. 1251-1271, 2018.
Doi:10.1590/0001-3765201820170830.
Silveira, F.F.; Feitosa, L.M. ; Mafra, J.C. M. ; Ferreira,M.L.G. ; Rogerio, K.R. ; Carvalho, L.J. M. ; Boechat, N. ; Pinheiro, L.C. S. Synthesis and anti-plasmodium falciparum evaluation of novel pyrazolopyrimidine derivatives. Medicinal chemistry research, v. 27, p. 1876-1884, 2018.
Hoelz, L.V.B. ; Calil, F.A. ; Nonato, M.C. ; Pinheiro, L.C.S. ; Boechat, N. Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria. Future medicinal chemistry , v. 10, p. 1853-1874, 2018.
Costa, C.C.P. ; Boechat, N. ; Bastos, M.M. ; Silva, F.C. ; Marttorelli, A. ; Souza, T.M.L. ; Baptista, M.S.. ; Hoelz, L.V.B. ; Cafffarena, E.R . New efavirenz derivatives and 1,2,3-triazolyl-phosphonates as inhibitors of reverse transcriptase of hiv-1. Current topics in medicinal chemistry, v. 18, p. 1494-1505, 2018.
Doi: 10.2174/1568026618666181029150118.
Giorno, T.B.S. ; Moreira, I.G.S. ; Rezende, C.M. ; Fernandes, P.D . New βn-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice. Scientific reports , v. 8, p. 10027, 2018.
Doi: 10.1038/s41598-018-28355-4.
Santos, C.C.S. ; Guilhon, C.C. ; Moreno, D.S.A. ; Alviano, C.S. ; Estevam, C.S. ; Blank,A.F. ; Fernandes, P.D . Anti-inflammatory, antinociceptive and antioxidant properties of schinopsis brasiliensis bark. Journal of ethnopharmacology , v. 213, p. 176-182, 2018.
Cortes, A.L. ; Gonsalez, S.R. ; Rioja, L.S. ; Oliveira, S.S.C. ; Santos, A.L.S. ; Prieto, M. C. ; Melo, P.A. ; Lara, L.S. Protective outcomes of low-dose doxycycline on renal function of wistar rats subjected to acute ischemia/reperfusion injury. Biochimica et biophysica acta-molecular basis of disease , v. 1864, p. 102-114, 2018.
Doi:10.1016/j.bbadis.2017.10.005
Strauch, M.A. ; Souza, G.J. ; Pereira, J.N. ; Ramos, T.S. ; Cesar, M.O. ; Tomaz, M.A.; Machado, M.M.S.; Neto, F.C.P. ; Melo, P.A. True or false coral snake: is it worth the risk? A micrurus corallinus case report. Journal of venomous animals and toxins including tropical diseases , v. 24, p. 10, 2018.
Nunes, C. F. C. G. ; Nogueira , J.S.; Canto, F.B. ; Vianna, P. H. O. ; Bt, C.; Silva,P.M. R. ; Rodrigues, K. ; Pillotto, R. M. ; Busch, M. ; Atella, G. C. ; Vale, A. ; Bellio, M. ; Nobrega, A. ; Fucs, R. Probiotic treatment during neonatal age provides optimal protection against experimental asthma through modulation of microbiota and regulatory t cells. International immunology, 2018.
Quintanilha, I. G.A. ; Abreu, A.V. ; Ferreira, A. C. ; Nascimento, D. O. ; Siqueira, A. M. ; Campbell , R.; Ferreira, T. P. T. ; Gutierrez, T.M.; Ribeiro, G. C.M. ; Silva, P.M.R.; Carvalho, A.; Bozza P.T. ; Zimmermann, G.; Neto,C.C.F. Integrin αdβ2 (cd11d/cd18) mediates experimental malaria-associated acute respiratory distress syndrome (ma-ards). Malaria journal (online), 2016.
Fernandes, T.A.; Milla, P.V.; Ravasco, J.M.J.M. ; Martínez,A.O. ; Sansano, J.M. ; Nájera, C. ; Costa, P.R.R. ; Fiser, B. ; Bengoa, E.G. Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes. Tetrahedron: asymmetry (print), v. 27, p. 118-122, 2016.
Doi: 10.1016/j.tetasy.2015.12.004
Fernandes, T.A. ; Manvar, D.; Domingos, J.L.O. ; Basu, A.; Nichols, D.B. ; Basu, N.K.; Costa, P.R.R . 5-carba-pterocarpens: a new scaffold with anti-hcv activity. European journal of medicinal chemistry, v. 112, p. 33-38, 2016.
Doi:10.1016/j.ejmech.2016.02.010
Junior, E. F.C. ; Martins, T. M. ; Cavalheiro, M. M.C. ; Marques, P. R. ; Portari, E. A. ; Coelho, M. G. P. ; Netto, C. D. ; Costa, P.R.R. ; Sabino, K. C. C. ; Santos, E. C.T . Preclinical studies evaluating subacute toxicity and therapeutic efficacy of lqb-118 in experimental visceral leishmaniasis. Antimicrobial agents and chemotherapy, v. 60, p. 3794-3801, 2016.
Neto, V.V.A. ; Júnior, E.F.C. ; Cavalheiro, M.M.C. ; Atella, G.C. ; Fernandes, T.A. ; Costa, P.R.R. ; Santos, E.C.T . Antileishmanial activity of ezetimibe: inhibition of sterol biosynthesis, in vitro synergy with azoles, and efficacy in experimental cutaneous leishmaniasis. Antimicrobial agents and chemotherapy, v. 60, p. 6844-6852, 2016.
Salustiano,E.J. ; Dumas, M.L. ; Santos, G.G.S. ; Netto, C.D. ; Costa, P.R. R. ; Rumjanek, V.M . In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone lqb-118. Investigational new drugs, v. 34, p. 541-551, 2016.
Doi: 10.1007/s10637-016-0359-2
Silva, T.L. ; Ferreira, F.R. ; Vasconcelos, C.C. ; Silva, R.C. ; Lima, D.J.P. ; Costa, P.R.R. ; Netto, C.D. ; Goulart, M.O. F. Reactive oxygen species release, alkylating ability, and dna interactions of a pterocarpanquinone: a test case for electrochemistry. Chemelectrochem, v. 3, p. 2252-2263, 2016.
Riça, I.G. ; Netto, C.D. ; Rennó, M.N. ; Abreu, P.A. ; Costa, P.R.R. ; Silva, A.J.M. ; Cavalcante, M.C.M . Anti-inflammatory properties of pterocarpanquinone lqb-118 in mice. Bioorganic & medicinal chemistry, v. 24, p. 4415-4423, 2016.
Barcellos, J.C.F. ; Vilela, G.V.M.A. ; Borges, B.H.F. ; Miranda, M.F.F. ; Dias, A.G. ; Costa, P.R.R . The syn-selective conjugate addition of amines to enoates derived from d-mannitol. Tetrahedron-asymmetry, v. 27, p. 773-776, 2016.
Doi:10.1016/j.tetasy.2016.06.017
Cívicos, J.F. ; Rocha, C.M. ; Costa, P.R.R. ; Nájera, C. Copper-versus palladium-catalyzed aromatization of 2-(methoxycarbonyl) tetralones: synthesis of methyl 1-hydroxy-2-naphthoates. Tetrahedron, v. 72, p. 1897-1902, 2016.
Nesi, R. T. ; Souza, P. S. ; Santos, G. P. ; Thirupathi, A. ; Menegalli, B. ; Silveira, c.l. ; silva, P.L.A. ; Valença, S.S. ; Pinho, R.A . Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice. International journal of copd, v. 11, p. 603-610, 2016.
Carvalho, G.M.C. ; Oliveira, V.R. ; Casquilho, N.V.; Araujo, A. P. ; Soares, R.M. ; Azevedo S.M.F.O. ; Pires,K.M.P. ; Valença, S.S. ; Zin,W.A . Pulmonary and hepatic injury after sub-chronic exposure to sublethal doses of microcystin-lr. Toxicon (oxford), v. 112, p. 51-58, 2016.
Doi: 10.1016/j.toxicon.2016.01.066
Robert, S. ; Gicquel, T. ; Victoni, T. ; Valenca, S. S. ; Barreto, E. ; Maitre, B.B. ; Boichot, E. ; Lagente, V. Involvement of matrix metalloproteinases (mmps) and inflammasome pathway in molecular mechanisms of fibrosis. Bioscience reports, v. 36, p. E00360-e00360, 2016.
Feitosa , E.K. ; Okuto, R. T. ; Ribeiro, V.P. ; Lanzetti,M. ; Barroso , M.V. ; Zin, W.A. ; Porto, L. C. ; Gitirana, L.B. ; Valenca, S. S. . Eucalyptol attenuates cigarette smoke-induced acute lung inflammation and oxidative stress in the mouse. Pulmonary pharmacology & therapeutics, v. 41, p. 11-18, 2016.
Doi: 10.1016/j.pupt.2016.09.004
Gomes, M.D.M. ; Carvalho, G.M. C. ; Casquilho, N.V. ; Araújo, A.C. P. ; Valença, S.S. ; Cardoso, J.H.L. ; Zin, W.A . 2,2--azobis (2-amidinopropane) dihydrochloride is a useful tool to impair lung function in rats. Frontiers in physiology, v. 7, p. 475, 2016.
Nunes, I.K.C. ; Souza, E.T. ; Cardozo, S.V.S. ; Carvalho, V.F. ; Romeiro, N.C. ; Silva, P.M.R. ; Martins, M.A. ; Barreiro, E.J. ; Lima, L.M . Synthesis, pharmacological profile and docking studies of new sulfonamides designed as phosphodiesterase-4 inhibitors. Plos one , v. 11, p. E0162895, 2016.
Doi: 10.1371/journal.pone.0162895
Thota, S. ; Vallala, S. ; Yerra,R. ; Rodrigues, D.A. ; Barreiro, E.J. Design, synthesis, structural characterization and in vitro cytotoxic activity of mononuclear ru(ii)complexes. Medicinal chemistry research , v. 25, p. 2127-2132, 2016.
Montes, G. C. ; Hammes, N. ; Rocha, M. D. ; Montagnoli, T. L. ; Fraga, C. A. M. ; Barreiro, E. J. ; Sudo, R. T. ; Sudo, G.Z. . Treatment with adenosine receptor agonist ameliorates pain induced by acute and chronic inflammation. The journal of pharmacology and experimental therapeutics (online) , v. 358, p. 315-323, 2016.
Filho, C.C.M. ; Dantas, R.F. ; Braga, R.C. ; Neves, B.J.; Senger, M.R. ; Valente, W.C.G. ; Neto, J.M.R. ; Chaves, W.T. ; Muratov, E.N. ; Paveley, R.A. ; Furnham, N. ; Kamentsky, L. ; Carpenter, A.E. ; Junior, F.P.S. ; Andrade, C.H. Qsar-driven discovery of novel chemical scaffolds active against schistosoma mansoni. Journal of chemical information and modeling , v. 56, p. 1357-1372, 2016.
Neves, B.J. ; Dantas, R.F. ; Senger, M.R. ; Filho, C.C.M. ; Valente, W.C.G. ; Almeida, A.C.M. ; Lima, E.F. C. ; Neto, J.M.R. ; Paveley, R.A. ; Furnham, N. ; Muratov, E.N. ; Kamentsky, L. ; Carpenter, A.E. ; Braga, R.C. ; Junior, F.P.S ; Andrade, C.H. Discovery of new anti-schistosomal hits by integration of qsar-based virtual screening and high content screening. Journal of medicinal chemistry , v. 59, p. 7075-7088, 2016.
Doi: 10.1021/acs.jmedchem.5b02038
Boechat, N.; Bastos, M. M. ; Costa, C. C. P. ; Bezerra, T. C. ; Silva, F. C. Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: approaches based on its medicinal chemistry. European journal of medicinal chemistry, v. 108, p. 455-465, 2016.
Doi: 10.1016/j.ejmech.2015.11.025
Coutinho, J. P.; Almela, M. ; Blanco, C.M. ; Herreros, E. ; Sa, P. M. ; Boechat, N. ; Krettli, A.U . Transmission-blocking potential of mefas, a hybrid compound derived from artesunate and mefloquine. Antimicrobial agents and chemotherapy , v. 60, p. 3145-3147, 2016.
Carvalho, R.C.C. ; Martins, W. A. ; Silva, T. P. ; Kaiser, C.R. ; Bastos, M. M. ; Pinheiro, L.C.S. ; Krettli, A. U. ; Boechat, N. New pentasubstituted pyrrole hybrid atorvastatin-quinoline derivatives with antiplasmodial activity. Bioorganic & medicinal chemistry letters (print) , p. 1881-1884, 2016.
Doi:10.1016/j.bmcl.2016.03.027
Ayala, A. P. ; Honorato,S.B. ; Silva, C. C.P. ; Mendonca, J. S. ; Boechat, N. ; Ellena, J . On the thermal stability of the diethylcarbamazine-fortified table salt used in the control of lymphatic filariasis. Journal of pharmaceutical sciences , v. 105, p. 2437-2443, 2016.
Doi: 10.1016/j.xphs.2016.06.003.
Boechat, N.; Carvalho, A.S. ; Quaresma, B.M. C. S. ; Wardell, J. l. ; Wardell, S.M. S. V. 4-cyclopropyl-1-(1-methyl-4-nitro-1h-imidazol-5-yl)-1h-1,2,3-triazole and ethyl 1-(1-methyl-4-nitro-1h-imidazol-5-yl)-1h-1,2,3-triazole-4-carboxylate. Journal of chemical crystallography , v. 2016, p. 1-7, 2016.
Silva, T.B. ; Bernardino, A.M.R. ; Ferreira, M.L.G. ; Rogerio, K.R. ; Carvalho, L.J.M. ; Boechat, N. ; Pinheiro, L.C.S.Design, synthesis and anti-p. Falciparum activity of pyrazolopyridine-sulfonamide derivatives. Bioorganic & medicinal chemistry (print), v. 24, p. 4492-4498, 2016.
Doi: 10.1016/j.bmc.2016.07.049
Boechat, N.; Bastos, M. M. ; Hoelz, L.V.B. ; Oliveira, A. P. Antileishmanial chemotherapy: a literature review. Revista virtual de química, v. 8, p. 2072-2104, 2016.
Doi: 10.21577/1984-6835.20160139
Giorno, T.B.S. ; Silva, B.V. ; Pinto, A.C. ; Fernandes, P.D . Antinociceptive effect and mechanism of action of isatin, n-methyl isatin and oxopropyl isatin in mice. Life sciences (1973) , v. 151, p. 189-198, 2016.
Doi: 10.1016/j.lfs.2016.02.052.
Amorim, J.L. ; Simas, D.L.R. ; Pinheiro, M.M.G. ; Moreno, D.S.A. ; Alviano, C.S. ; Silva, A.J.R. ; Fernandes, P.D. Anti-inflammatory properties and chemical characterization of the essential oils of four citrus species. Plos one , v. 11, p. E0153643, 2016.
Doi:10.1371/journal.pone.0153643
Calixto,N. ; Cordeiro, M. ; Giorno, T. ; Oliveira, G. ; Lopes, N. ; Fernandes, P.D. ; Pinto,A.; Rezende,C . Chemical constituents of psychotria nemorosa gardner and antinociceptive activity. Journal of the brazilian chemical society (impresso) , v. 1, p. 1-17, 2016.
Doi:10.21577/0103-5053.20160219
Donald, G.R.; Fernandes, P. D. ; Boylan, F. Antinociceptive activity of zanthoxylum piperitum dc. Essential oil. Evidence-based complementary and alternative medicine (online) , v. 2016, p. 1-8, 2016.
Guerra, F.S.; Sampaio, L.S.; Konig, S.; Bonamino, M.; Rossi, M.L.D.; Costa, M.L.; Fernandes, P.D. ; Mermelstein, C . Membrane cholesterol depletion reduces breast tumor cell migration by a mechanism that involves non-canonical wnt signaling and il-10 secretion. Translational medicine communications, v. 1, p. 3-13, 2016.
Carvalho, P.R. ; Ropero, D.R. ; Pinheiro, M.M. ; Fernandes, P.D. ; Boylan, F . Quinoline alkaloids isolated from choisya aztec-pearl and their contribution to the overall antinociceptive activity of this plant. Plos one , v. 11, p. E0164998, 2016.
Doi:10.1371/journal.pone.0164998
Serra, M. F. ; Neves, J.S.; Couto, G. C. ; Cotias, A. C. ; Pao, C. R. R. ; Olsen, P. C ; Valota, E.A. ; Coelho , L.P.; Faria, R.X. ; Costa, J.C.S. ; Cordeiro, R. S.B. ; Silva, P.M.R.; Martins, M. A . Jm25-1, a non-anesthetic lidocaine analogue combining airway relaxant, anti-inflammatory and antieosinophilic properties: implications for new asthma therapy.. Anesthesiology (philadelphia), 2016.
2017
Camargo, G.A.C.D. ; Silva, N.L.C. ; Miranda, A.L.P. ; Tributino, J.L.M. ; Colombo, N.H. ; Duque, C. . Periodontopathogens, candida spp. And immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis. Brazilian journal of oral sciences, v. 15, p. 226-233, 2017.
Doi: 10.20396/bjos.v15i3.8649993
Silva, R. V. ; Oliveira, J. T ; Santos, . L. R ; Dias, F C ; Martinez, A M B ;Lima, C.F.K. ; Miranda, A.L.P . Long-chain omega-3 fatty acids supplementation accelerates nerve regeneration and prevents neuropathic pain behavior in mice. Frontiers in pharmacology, v. 8, p. 723, 2017.
Betti,A.H.. ; Antonio,C.B. ; Pompeu,T.E.T. ; Martins, T.S. ; Herzfeldt, V. ; Stolz, E.D. ; Fraga, C.A.M. ; Barreiro, E.J. ; Noël, F. ; Rates, S.M.K. Lassbio-1422. Behavioural pharmacology , v. 28, p. 48-62, 2017.
Silva,J.; Costa, D.G. ; Sudo, R.; Wang, H. ; Groban, L. ; Ferraz, E. ; Nascimento,J. ; Fraga,C.A.M. ; Barreiro, E.J. ; Sudo, G.Z. Adenosine a2a receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction. Drug design, development and therapy , v. Volume11, p. 553-562, 2017.
Carvalho, S.A. ; Osorio, L.F.B. ; Salomão,K. ; Castro, S.L. ; Wardell, S.M. S. V. ; Wardell, J.L. ; Silva, E.F. ; Fraga, C.A.M . Design, synthesis, and trypanocidal activity of novel 5-nitroimidazolyl -benzyloxime ethers. Journal of heterocyclic chemistry , v. 54, p. 3626-3631, 2017.
Carvalho, V.F. ; Ferreira, T.P.T. ; Arantes, A.C. S. ; Noël, F. ; Tesch, R. ; Sant’anna, C. M. R. ; Barreiro, E.J. L. ; Fraga, C.A.M. ;Silva, P.M.R. ; Martins, M.A.Lassbio-897 reduces lung injury induced by silica particles in mice: potential interaction with the a2a receptor. Frontiers in pharmacology , v. 8, p. 1, 2017.
Savio, l. E. ; Mello, P. ; Figliuolo, V. ; Almeida, T. ; Santana, P. ; Oliveira,S.D.S. ; Silva, C.L.M. ; Fedbrugge, l. ; Csizmadia, E. ; Minshall, R. ; Longhi, M. S. ; Wu, Y. ; Simon, R. ; Silva,R.C. Cd39 limits p2x7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. Journal of hepatology , v. 67, p. 1, 2017.
Doi:10.1016/j.jhep.2017.05.021
Cardoso, T. C. ; Pompeu, T. E. ; Silva, C.L.M . The p2y1 receptor-mediated leukocyte adhesion to endothelial cells is inhibited by melatonin. Purinergic signalling , p. 1, 2017.
Ibiapino, A.L. ; Figueiredo, L.P. ; Lima, L.M. ; Barreiro, E.J.. ; Punzo,F. ; Ferreira, F.F. Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents. New journal of chemistry , v. 41, p. 000-000, 2017.
Figueiredo, L.P. ; Ibiapino, A.L. ; Amaral, D.N. ; Ferraz, L.S. ; Rodrigues, T ; Barreiro, E.J. ; Lima, L.M. ; Ferreira, F.F. Structural characterization and cytotoxicity studies of different forms of a combretastatin a4 analogue. Journal of molecular structure , v. 1147, p. 226-234, 2017.
Doi:10.1016/j.molstruc.2017.06.093
Bastos, I.T.S. ; Costa, F.N. ; Silva, T.F. ; Barreiro, E.J. ; Lima, L.M. ; Braz, Delson ; Lombardo, G.M. ; Punzo, F. ; Ferreira, F.F. ; Barroso, R.C. A combined experimental and in silico characterization to highlight additional structural features and properties of a potentially new drug. Journal of molecular structure , v. 1146, p. 735-743, 2017.
Doi:10.1016/j.molstruc.2017.06.061
Amaral, D. ; Alves, F.S. ; Barreiro, E.J. ; Laufer, S. ; Lima,L.M . Multi-gram preparation of 7-nitroquinoxalin-2-amine. Journal of the brazilian chemical society , v. 28, p. 1874-1878, 2017.
Doi:10.21577/0103-5053.20170018
Alencar, A.K.N. ; Montes, G.C. ; Barreiro, E.J. ; Sudo, R.T. ; Sudo, G.Z. Adenosine receptors as drug targets for treatment of pulmonary arterial hypertension. Frontiers in pharmacology , v. 8, p. 858, 2017.
Sodero, A. C. R. ; Vieira, B.A. ; Torres, P.H.M.; Pascutti, P. G. ; Garcia, C. R. S. ; Ferreira, V. F. ; Rocha,D.R. ; Ferreira, S. B. ; Júnior, F.P.S . Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling. Memórias do instituto oswaldo cruz , v. 112, p. 299-308, 2017.
Gasparotto, J. ; Kunzler, A. ; Senger, M. R. ; Souza, C.S.F. ; Simone, S.G. ; Bortolin, R.C.; Somensi, N. ; Pizzol, F.D. ; Moreira, J.C.F. ; Silva, A. L.A. ; Calabrese, K.S. ; Junior, F.P.S. ; Gelain, D.P . N-acetyl-cysteine inhibits liver oxidative stress markers in balb/c mice infected with leishmania amazonensis. Memórias do instituto oswaldo cruz (online) , v. 112, p. 146-154, 2017.
Azevedo, L.D. ; Bastos, M.M. ; Vasconcelos, F.C. ; Hoelz, L.V. B. ; Junior, F.P. S. ; Dantas, R.F. ; Almeida, A.C. M. ; Oliveira, A.P. ; Gomes, L.C. ; Maia, R.C. ; Boechat,N. Imatinib derivatives as inhibitors of k562 cells in chronic myeloid leukemia. Medicinal chemistry research , p. 1-13, 2017.
Doi: 10.1007/s00044-017-1993-8
Godinho, A. N. ; Costa, G. T. ; Oliveira, N. O. ; Cardi, B. A. ; Uchoa, D. E. ; Silveira, E. R. ; Quintas, L. E. M. ; Noël, F.G. ; Carvalho, K. M. ; Fonteles, M. C. ; Santos, C. F. ; Lessa, L. M. A. ; Nascimento, N. R. F. Effects of cardiotonic steroids on isolated perfused kidney and nhe3 activity in renal proximal tubules. Biochimica et biophysica acta-general subjects , v. 1861, p. 1943-1950, 2017.
Doi: 10.1016/j.bbagen.2017.05.012
Souza, G.A.T. ; Gropillo, I. ; Neves, J.S. . Cysteinyl leukotrienes in eosinophil biology: functional roles and therapeutic perspectives in eosinophilic disorders. Frontiers in medicine, v. 4, p. 106, 2017.
Sena, G. C. ; Merlo, E. ; podratz, P. L. ; Araujo, J. F. ; Lima, L.F.C. ; Brandao, P. A. ; Carneiro, M. T. ; Zicker, M. C. ; Ferreira, A. V.M. ; Takiya, C. M. ; Silva, A. P.S. ; Alves, L.M.; Silva, I. V. ; Graceli, J. B. Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats. Toxicology and applied pharmacology , v. 319, p. 22-38, 2017.
Doi:10.1016/j.taap.2017.01.021
Pópulo, H. ; Nunes, B ; Sampaio, C. ; Batista, R. ; Pinto, M.T. ; Gaspar, T.B. ; Alves, L.M. ; Cai, R. ; Zhang, X.Y. ; Schally, A.V. ; Simões, M.S. ; Soares, Paula . Inhibitory effects of antagonists of growth hormone-releasing hormone (ghrh) in thyroid cancer. Hormones & cancer , v. 8, p. 314-324, 2017.
Silva, A.P.S. ; Andrade, M.N. ; Rodrigues,P.P. ; Melo, F.D.P. ; Soares, P. ; Graceli, J.B. ; Dias, G.R.M. ; Ferreira, A.C.F. ; Carvalho, D.P. ; Alves, L.M. Frontiers in endocrine disruption: impacts of organotin on the hypothalamus-pituitary-thyroid axis. Molecular and cellular endocrinology , v. 460, p. 246-257, 2017.
Frattani, F.S. ; Lima, L.M. ; Barreiro, E.J. ; Zingali, R.B. The antithrombotic and haemostatic effects of lassbio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats. Journal of pharmacy and pharmacology , v. 69, p. 1374-1380, 2017.
Moraes, B.S. ; Azeredo, F.J. ; Izoton, J.C. ; Amaral, M.; Barreiro,E.J.; Freddo, R.J. ; Costa, T.D. ; Lima,L.M.; Haas, S.E. Leishmanicidal candidate lassbio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution. Xenobiotica , v. 21, p. 1-32, 2017.
Doi: 10.1080/00498254.2017.1405465
Dias ; A. F. ; Lara, L. S. ; Filho , H.M. ; Vieyra, A. Is angiotensin-(3-4) (val-tyr), the shortest angiotensin ii derived peptide, opening new vistas on renin angiotensin system?. Jraas. Journal of the renin-angiotensin-aldosterone system , v. 18, p. 147032031668933, 2017.
Lara, L. S.; Bourgeois, C. ; El-dahr, S. ; Prieto, M.C . Bradykinin/b receptor activation regulates renin in m 1 cells via protein kinase c and nitric oxide. Physiological reports, v. 5, p. E13211, 2017.
Mendes , L.V.P. ; Gonsalez , S.R. ; Pinto, L.M.O. ; Acacio, A. P. ; Takya, C.M. ; Nascimento, J.H.M. ; Lamas, M.E. ; Vieyra, A. ; Cunha, V.M.N.; Lara, L. S. Long-term effect of a chronic low-protein multideficient diet on the heart: hypertension and heart failure in chronically malnourished young adult rats. International journal of cardiology , p. 31864, 2017.
Doi: 10.1016/j.ijcard.2017.03.110
Ferrão, F.M. ; Cardoso, L.H.D. ; Drummond, H.A. ; Li, X.C. ; Zhuo, J.L. ; Gomes, D.S. ; Lara, L.S. ; Vieyra, A. ; Lowe,J. Luminal angiotensin ii is internalized as a complex with at r/at r heterodimers to target endoplasmic reticulum in llc-pk cells. American journal of physiology-renal physiology , v. 3, p. Ajprenal.00261.2016, 2017.
Doi: 10.1152/ajprenal.00261.2016
Gonzalez, A.A. ; Lara, L.S. ; Prieto, M.C. Role of collecting duct renin in the pathogenesis of hypertension. Current hypertension reports , v. 19, p. 62, 2017.
Doi: 10.1007/s11906-017-0763-9
Sampaio, L.S. ; Silva, P.A. ; Ribeiro, V.S. ; Chaves, C.C. ; Lara, L.S. ; Vieyra, A. ; Lamas, M.E. Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?. Lipids in health and disease , v. 16, p. 245, 2017.
Doi: 10.1186/s12944-017-0634-z
Rodrigues, A. ; Guimarães, D. ; Konno, T. ; Tinoco, L.W. ; Barth, T. ; Aguiar, F. ; Lopes, N. ; Leal,I. ; Raimundo, J. ; Muzitano, M . Phytochemical study of tapirira guianensis leaves guided by vasodilatory and antioxidant activities. Molecules (basel. Online) , v. 22, p. 304, 2017.
Doi: 10.3390/molecules22020304
Griffith, C.M. ; Williams, P.B. ; Tinoco, L.W. ; Dinges, M.M. ; Wang, Y. ; Larive, C.K. 1 h nmr metabolic profiling of earthworm ( eisenia fetida ) coelomic fluid, coelomocytes, and tissue: identification of a new metabolite-malylglutamate. Journal of proteome research , v. 16, p. 3407-3418, 2017.
Doi: 10.1021/acs.jproteome.7b00439
Prevatto, J.P. ; Torres, R.C. ; Diaz, B.L. ; Silva, P.M. R. E ; Martins, M.A. ; Carvalho, V.F . Antioxidant treatment induces hyperactivation of the hpa axis by upregulating acth receptor in the adrenal and downregulating glucocorticoid receptors in the pituitary. Oxidative medicine and cellular longevity , v. 2017, p. 1-10, 2017.
Alves, A. ; Assis, A. ; Vieira, G.C. ; Martins, M.A. ; Filho, J.M.B. ; Piuvezam, M.R . Milonine, an alkaloid of cissampelos sympodialis eichl. (menispermaceae) inhibits histamine release of activated mast cells. Inflammation , v. 40, p. 1-11, 2017.
Castro, L.L. ; Xisto, D.G. ; Kitoko, J.Z. ; Cruz, F.F. ; Olsen, P.C. ; Redondo, P.A.G.; Ferreira, T.P.T. ; Weiss, D.J. ; Martins, M.A. ; Morales, M.M. ; Rocco, P.R.M . Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma. Stem cell research & therapy , v. 8, p. 151-162, 2017.
Doi: 10.1186/s13287-017-0600-8
Kitoko, J.Z. ; Castro, L.L. ; Nascimento, A.P. ; Abreu, S.C. ; Cruz, F.F. ; Arantes, A.C. ; Xisto, D.G. ; Martins, M.A. ; Morales, M.M. ; Rocco, P.R.M. ; Olsen, P.C. Therapeutic administration of bone marrow-derived mesenchymal stromal cells reduces airway inflammation without upregulating tregs in experimental asthma. Clinical and experimental allergy , v. 0001, p. 14-0015, 2017.
Socodato, R. E. S. ; Santiago, F. N. ; Portugal, C. C. ; Domith, I. ; Encarnacao, T. G. ;Loiola, E. C. ; Ventura, A. L. M. ; Cossenza, M. ; Relvas, J. B. ; Castro, N. G. ; Carvalho, R.P. Dopamine promotes nmda receptor hypofunction in the retina through d1 receptor-mediated csk activation, src inhibition and decrease of glun2b phosphorylation. Scientific reports, v. 7, p. 40912, 2017.
Azeredo, L.F.S.P; Coutinho, J.P. ; Jabor, V.A.P. ; Feliciano, P. R. ; Nonato, M. C. ; Kaiser, C.R. ; Menezes, C. M. R. ; Hammes, A. S. O. ; Caffarena, E. R. ; Hoelz, L.V.B. ; Souza, N. B. ; Pereira, G. A. N. ; Ceravolo, I. P. ; Krettli, A.U. ; Boechat, N. Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-plasmodium falciparum, antimalarial, and pf-dihydroorotate dehydrogenase inhibitors. European journal of medicinal chemistry, v. 126, p. 72-83, 2017.
Doi: 10.1016/j.ejmech.2016.09.073
Sacramento, C.Q.M.; Freitas, C.S.G. Rocha, N.H.; Miranda,L.V.B.; Rodrigues,M.F.; Marttorelli,N.; Ferreira,A. Lima,A.C.B. Abrantes,G.; Vieira, J.L. ; Bastos,Y.R.; Volotão,M.M.M.; Nunes,E.; Tschoeke,E.P.; Leomil, D.A.; loiola,L.; Trindade,E.C.; Rehen,P.; Bozza, S.K.; Bozza, F.A.; Patrícia T. Boechat, N.T.;, Filippis, A.M.B.F.L. The clinically approved antiviral drug sofosbuvir inhibits zika virus replication. Scientific reports , v. 7, p. 40920, 2017.
Boechat, N.; Branco, F. S. C. ; França, R.R.F. ; Domingos, J.L. ; Menozzi, C.A.C . Optimization of fluconazol synthesis: an important azole antifungal drug. Revista virtual de química, v. 9, p. 1216-1234, 2017.
Doi: 10.21577/1984-6835.20170071
Boechat, N.; Bastos, M.M. ; Azevedo, L.D. ; Oliveira, A.P . Sínteses e propriedades de fármacos inibidores da tirosina quinase bcr-abl, utilizados no tratamento da leucemia mieloide crônica. Química nova (online) , p. 01-19, 2017.
Doi:10.21577/0100-4042.20170027
Azevedo, L.D. ; Bastos, M. M. ; Vasconcelos, F. ; Hoelz, L.V. B. ; Junior, F. P. ; Dantas, R. F. ; Almeida, A. C. M. ; Oliveira, A. P. ; Gomes, L. C. ; Maia, R. C. ; Boechat, N. Imatinib derivatives as inhibitors of k562 cells in chronic myeloid leukemia. Medicinal chemistry research, v. 26, p. 2929-2941, 2017.
Doi: 10.1007/s00044-017-1993-8
Faria, J.V. ; Vegi, P.F. ; Miguita, A.G.C. ; Santos, M.S. ; Boechat, N. ; Bernardino, A.M.R. Recently reported biological activities of pyrazole compounds. Bioorganic & medicinal chemistry, v. 25, p. 5891-5903, 2017.
Doi: 10.1016/j.bmc.2017.09.035
Venâncio, T.; Oliveira, L.M. ; Ellena, J. ; Boechat,N. ; Brown, S.P. Probing intermolecular interactions in a diethylcarbamazine citrate salt by fast mas 1 h solid-state nmr spectroscopy and gipaw calculations. Solid state nuclear magnetic resonance , v. 87, p. 73-79, 2017.
Doi: 10.1016/j.ssnmr.2017.02.006
Sacramento, C.Q.M.; Freitas, C.S.G.; Rocha, N.H.; Miranda,L.V.B.; rodrigues, natalia Marttorelli,M.F.; Ferreira, A.C.A.; Lima, G.A.B.; Vieira,J.L.; Bastos,Y.R.; Volotão,M.M; Nunes, E.M.; Tschoeke,E.P. ;Leomil,D.A. Loiola,L. Trindade, E.C.; Rehen,P.; Bozza,S.K.; Bozza,F.A.; Patrícia T.; Boechat, N.T.; Filippis,F.L. Ana M. B. Corrigendum: the clinically approved antiviral drug sofosbuvir inhibits zika virus replication. Scientific reports, v. 7, p. 46772, 2017.
Sobrinho, A.P.; Minho, A.S. ; Ferreira, L.L.C. ; Martins, G.R. ; Boylan, F. ; Fernandes, P.D . Characterization of anti-inflammatory effect and possible mechanism of action of action of Tibouchina granulosa. Journal of pharmacy and pharmacology , v. 1, p. Early view, 2017.
Silva, E.R. ; Bizzo, H.R. ; Fernandes, P.D. ; Junior, V.F.V. ; Leitão, S.G. ; Oliveira, D.R. Development and evaluation of an inhalation chamber for in vivo tests. Anais da academia brasileira de ciencias , v. 1, p. 1-11, 2017.
Doi:10.1590/0001-3765201720160793
Guerra, F.S.; Oliveira, R.G.; Fraga, C.A.M.; Mermelstein, C.S.; Fernandes, P.D . Rock inhibition with fasudil induces beta-catenin nuclear translocation and inhibits cell migration of mda-mb 231 human breast cancer cells. Scientific reports , v. 7, p. 13723, 2017.
Doi:10.1038/s41598-017-14216-z
Leitão, G.G. ; Pereira, J.P.B. ; Carvalho, P.R. ; Ropero, D.R. ; Fernandes, P. D. ; Boylan, F . Isolation of quinoline alkaloids from three choisya species by high-speed countercurrent chromatography and the determination of their antioxidant capacity. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy , v. 27, p. 297-301, 2017.
Doi:10.1016/j.bjp.2017.01.003.
Kartbaeva, E.B. ; Donald, G.R. ; Sakipova, Z.B. ; Ibragimova, L.N. ; Bekbolatova, E.N. ; Ternynko, I.I. ; Fernandes, P.D. ; Boylan, F. Antinociceptive activity of cistanche salsa stolons, growing in the republic of kazakhstan. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy , v. 27, p. 587-591, 2017.
Doi:10.1016/j.bjp.2017.05.013.
Silva, E.R. ; Oliveira, D.R. ; Fernandes, P.D. ; Bizzo, H.R. ; Leitão, S.G . Ethnopharmacological evaluation of breu essential oils from protium species administered by inhalation. Evidence-based complementary and alternative medicine , v. 2017, p. 1-10, 2017.
Simas, D.L.R. ; Reyes, M.S.M. ; Wug, M.A.M. ; Cordeiro, M.S. ; Giorno, T.B.S. ; Taracena, E.A. ; Hernández, B.E.O. ; Arévalo, J.V.M. ; Fernandes, P.D. ; Sabino, J.F.P. ; Silva,A.J.R. Chemical composition and evaluation of antinociceptive activity of the essential oil of cav. From guatemala. Natural product research , v. 1, p. 1-3, 2017.
Doi:10.1080/14786419.2017.1399376
Amorim, J.L. ; Figueiredo, J.B. ; Amaral, A.C.F. ; Barros, E.G.O. ; Palmero, C. ; Palantinos, M.A. ; Ramos, A.S. ; Ferreira, J.L.P. ; Silva, J.R.A. ; Benjamim, C.F. ; Basso, S.L. ; Nasciutti, L.E. ; Fernandes, P.D. Wound healing properties of copaifera paupera in diabetic mice. Plos one , v. 12, p. E0187380, 2017.
Doi: 10.1371/journal.pone.0187380
Ribeiro,T. ; Oliveira, J.T. ; Almeida,F.M. ; Tomaz, M.A.; Melo, P.A. ; Marques, S.A. ; Andrade, G.M. ; Martinez, A.M.B . Blockade of atp p2x7 receptor enhances ischiatic nerve regeneration in mice following a crush injury. Brain research , v. 115, p. 1111-11112, 2017.
Galvão, I. ; Vago, J. P. ; Barroso, L. C. ; Tavares , L.P.; Junior , C.M.Q.; Costa, V. V. ; Carneiro, F. S. ; Ferreira, T. P. T. ; Silva , P.M.; Amaral, F. A. ; Souza , L.P.; Teixeira, M. M. Annexin a1 promotes timely resolution of inflammation in murine gout. European journal of immunology, v. 47, p. 585-596, 2017.
Oliveira, L. G. ; Testasicca, M. C.S. ; Vargo , J.P.; Figueiredo, A. B. ; Canavaci, A. ; perucci, L. O. ; Ferreira, T. P. T. ; Coelho, E. A. F. ; Goncalves, D. U. ; Rocha, M. O. C. ; Silva , P;M.; Ferreira, C. N. ; Junior, C.Q. ; Souza, L.P.; Fernandes, A. P. Annexin a1 is involved in the resolution of inflammatory responses during leishmania braziliensis infection. Journal of immunology, v. 198, p. 3227-3236, 2017.
Dalmeida, A. P. L.; Silva , P.M.; Chiambarella, B.T. ; Martins, M.A. ; Bernardi, A. Α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International journal of nanomedicine, v. Volume 12, p. 4479-4491, 2017.
Coutinho, D.S. ; Valotta, E.A.A. ; Nascimento, C.V. M. F. ; Pires, A.L.A. ; Napimoga, M.H.; Carvalho, V.F. ; Torres, R.C. ; Silva, P.M. R. ; Martins, M.A. 15-deoxy-delta-12,14-prostaglandin j2 inhibits lung inflammation and remodeling in distinct murine models of asthma. Frontiers in immunology, v. 8, p. 1-12, 2017.
Ribeiro, E.L. ; Fragoso, I.T. ; Gomes, F.O.S. ; Oliveira, A.C. ; Silva, A.K.S. ; Silva, P.M.; Ciambarella, B.T. ; Ramos, I.P.R. ; Peixoto, C.A . Diethylcarbamazine: a potential treatment drug for pulmonary hypertension?. Toxicology and applied pharmacology, v. 333, p. 92-99, 2017.
Doi: 10.1016/j.taap.2017.08.015
Costa, P.R.R. Interaction between bioactive compound 11a-n-tosyl-5-deoxi-pterocarpan (lqb-223) and calf thymus dna: spectroscopic approach, electrophoresis and theoretical studies. International journal of biological macromolecules, alemanha, v. 96, p. 223-233, 2017.
Scatena, G.S. ; Cassiano, N.M. ; Netto, C.D. ; Costa, P.R.R. ; Cass, Q.B. ; Batista, J.M. Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone lqb-118. Chirality, v. 29, p. 167-171, 2017.
Cupello, M.P. ; Saraiva, F.M. ; Ippolito, P. ; Fernandes, A.S. ; Barreto, R.F.S.M. ; Costa, D.S.S. ; Paula, J.I.O. ; Costa, P.R.R. ; Nogueira, N.P. ; Felzenswalb, I. ; Dias, A.G. ; Paes, M.C. Mutagenic and cytotoxicity lqb 123 profile: safety and tripanocidal effect of a phenyl-t-butylnitrone derivative. Biomed research international, v. 2017, p. 1-8, 2017.
Costa, P.R.R.; Cívicos, J. ; Coimbra, J. Solvent-free synthesis of salen ligands and pd(ii)- and cu(ii)-salen complexes: their use in the oxidation of α-tetralones to α-naphthols. Synthesis-stuttgart, v. 49, p. A-1, 2017.
Cívicos, J. ; Costa, P.R.R. ; Domingos, J. Palladium-catalyzed α-arylation of dimethyl malonate and ethyl cyanoacetate with o-alkoxybromobenzenes for the synthesis of phenylacetic acid, esters and phenylacetonitriles. Synopen, v. 01, p. 0091-0096, 2017.
Ribeiro,V.P. ; Melo, A.C.; Feitosa, E.K. ; Reis, A.G. ; Barroso, M.V. ; Cavalieri, I.C. ; Carvalho, G.M.C. ; Zin, W.A. ; Porto, L.C. ; Gitirana, L.B. ; Lanzetti, M. ; Valença, S.S. Atorvastatin and simvastatin promoted mouse lung repair after cigarette smoke-induced emphysema. Inflammation, v. 40, p. 965-979, 2017.
Doi: 10.1007/s10753-017-0541-5
Nesi, R.T. ; Feitosa, E.K.; Lanzetti, M. ; Ávila, M.B.; Magalhães, C.B. ; Zin, W.A. ; Faffe, D.S. ; Porto,L.C. ; Valença, S.S . Inflammatory and oxidative stress markers in experimental allergic asthma. Inflammation, v. 40, p. 1166-1176, 2017.
Doi: 10.1007/s10753-017-0560-2
Cavalieri,I.C. ; Reis, A.G. ; Feitosa, E.K. ; Ribeiro, V.P. ; Lanzetti, M. ; Gitirana, L.B. ; Souza, B.R. ; Porto, L.C. ; Valença, S.S . Pulmonary emphysema cross-linking with pulmonary fibrosis and vice versa: a non-usual experimental intervention with elastase and bleomycin. Inflammation, v. 40, p. 1487-1496, 2017.
Doi: 10.1007/s10753-017-0590-9
Nesi, R.T. ; Barroso, M.V. ; Muniz, V.S. ; Arantes, A.C.; Martins, M.A. ; Gitirana, Lycia ; Neves, J.S. ; Benjamim, C.F. ; Lanzetti, M. ; Valença, S.S . Pharmacological modulation of reactive oxygen species (ros) improves the airway hyperresponsiveness by shifting the th1 response in allergic inflammation induced by ovalbumin. Free radical research, v. 51, p. 708-722, 2017.
Doi: 10.1080/10715762.2017.1364377
Barroso, M.V.; Cavalieri, I.C. ; Gitirana, L.B.; Fautrel, A. ; Lagente,V. ; Schmidt, M. ; Porto, L.C. ; Souza, B.R. ; Valença, S.S.; Lanzetti, M . Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of nrf2. Bioorganic & medicinal chemistry, v. 25, p. 5557-5568, 2017.
Doi: 10.1016/j.bmc.2017.08.026
Silva, C.O. ; Costa, A.M.A. ; Martins, M.R. ; Nascimento, F.V. ; Valença, S.S. ; Lagente, V. ; Pôrto,L. ; Victoni,T . Time course of the phenotype of blood and bone marrow monocytes and macrophages in the lung after cigarette smoke exposure in vivo. International journal of molecular sciences, v. 18, p. 1940, 2017.
Abe,F.S.F.A. ; Cunha, R.L.D.; Salomon, P.S.; Júnior, E.R.; Valença, S.S. ; Gitirana , L.B . Nanoecotoxicological effects of a sunscreen formulation based on tio2 nanoparticles on microalgae from guanabara bay (rio de janeiro, brazil). Moj polymer science, v. 1, p. 1-9, 2017.
Doi: 10.15406/mojps.2017.01.00014
Ribeiro, V.M. ; Bede, T.P. ; Rocha, G. ; Barroso, S. ; Valença, S.S. ; Azeredo, V.B . High fat diet and high polyphenols beverages effects in enzymatic and non-enzymatic antioxidant activity. Nutricion hospitalaria, v. 24, p. 169-175, 2017.
Matias, I. ; Diniz, L. P. ; Buosi, A. S. ; Neves, G. ; Stipursky, J. ; Gomes, F. C. A. . Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-?1. Frontiers in Aging Neuroscience, v. 9, p. 184, 2017.
Neves, G.; Borsoi, M.;, ANTONIO, C.; PRANKE, M.A.; BETTI, A. H.; RATES, M.S.K. Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects. Anais da Academia Brasileira de Ciências, 89(3), 1655-1669. 2017.
Doi: 10.1590/0001-3765201720160844
2016
Victoni, T. ; Gicquel, T.; Bodin,A. ; Daude, M. ; Tenor, H. ; Valença,S.S. ; Devillier,P. ; Porto, L.C. ; Lagente, V. ; Boichot, E . Roflumilast n-oxide associated with pge2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells. International immunopharmacology (print), v. 30, p. 1-8, 2016.
Doi: 10.1016/j.intimp.2015.11.019
Neto, L.A.S. ; Trajano, E.T.L. ; Lanzetti, M. ; Mendonça , M.S.A.; Guilherme, R. ; Figueiredo, R. T. ; Benjamim, C.F. ; Valença, S.S. ; Costa, A.M.A. ; Porto, L.C.M.S . Elastase modifies bleomycin-induced pulmonary fibrosis in mice. Acta histochemica (print), v. 118, p. 203-212, 2016.
Doi: 10.1016/j.acthis.2015.12.010
Cruz, M.F.S.J. ; Pereira, G.M. ; Ribeiro, M.G.; Silva, A.M. ; Tinoco, L.W. ; Silva, B.P.; Parente, J.P . Ingasaponin, a complex triterpenoid saponin with immunological adjuvant activity from inga laurina. Carbohydrate research (chicago, ill.. Print) , v. 420, p. 23-31, 2016.
Doi:10.1016/j.carres.2015.11.008
Casanova, L.M. ; Netto, J.M.E. ; Tinoco, L.W.; Penna, M.S. ; Costa, S.S . The use of nmr metabolite profiling and hypoglycemic assay for comparison of unfractionated aqueous leaf extracts of two species. Chemistry & biodiversity (print) , v. 13, p. 1-9, 2016.
doi: 10.1002/cbdv.201500180. Epub 2016 May 24
Barros, S.D.T. ; Senra, J.D. ; Tinoco, L.W. ; Simão, R.A. ; Lachter, E.R.; Malta, L.F.B . Characterization of a ternary system based on hybrid nanoparticles. Journal of nanoscience and nanotechnology (print), v. 16, p. 2822-2831, 2016.
Wang, H ; Sun, x. ; Sudo, G.Z. ; Lin,M. ; Groban,L. Cardiomyocyte-specific deletion of the g protein-coupled estrogen receptor (gper) leads to left ventricular dysfunction and adverse remodeling: a sex-specific gene profiling analysis. Biochimica et biophysica acta. Molecular basis of disease , v. S0925, p. 30247, 2016.
Doi: 10.1016/j.bbadis.2016.10.003
Wang, H. ; Alencar, A. ; Lin, M. ; Sun, X. ; Sudo, R.T. ; Sudo, G.Z. ; Lowe, D.A. ; Groban, L. Activation of gpr30 improves exercise capacity and skeletal muscle strength in senescent female fischer344 × brown norway rats. Biochemical and biophysical research communications (print) , v. 475, p. 81-86, 2016.
Doi: 10.1016/j.bbrc.2016.05.040
Wang, H. ; Silva,J. ; Alencar, A. ; Sudo,G.Z. ; Lin, M.S. ; Sun, X. ; Ahmad, S. ; Ferrario, C.M. ; Groban, L . Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized fischer344×brown norway rats. Journal of cardiovascular pharmacology , v. 68, p. 1-57, 2016.
Doi: 10.1097/fjc.0000000000000385
Alencar, A.K. ; Montes, G.C. ; Montagnoli, T.L. ; Silva, A.M.S. ; Martinez, S.T. ; Fraga, A.G. ; Wang, H. ; Groban, L. ; Sudo,R.T. ; Sudo, G.Z . Activation of gper ameliorates experimental pulmonary hypertension in male rats. European journal of pharmaceutical sciences , v. 97, p. 208-217, 2016.
Doi: 10.1016/j.ejps.2016.11.009
López, K.S.E. ; Marques, A.M. ; Moreira, D.L. ; Velozo, L.S. ; Sudo, R.T. ; Sudo, G.Z. ; Guimarães, E.F. ; Kaplan, M.A.C. Local anesthetic activity from extracts, fractions and pure compounds from the roots of ottonia anisum spreng. (piperaceae). Anais da academia brasileira de ciências (online) , v. 88, p. 2229-2237, 2016.
Doi:10.1590/0001-3765201620150821
Serra, M.F. ; Neves, J.S. ; Couto, G.C. ; Cotias, A.C. ; Pão, C.R. ; Olsen, P.C. ; Carvalho, K.I.M. ; Valotta, E.A. ; Faria, R.X. ; Costa, J. ; Cordeiro, R. ; Silva, P.M.R. ; Martins, M . Jm25-1, a lidocaine analog combining airway relaxant and antiinflammatory properties. Anesthesiology (philadelphia) , v. 124, p. 109-120, 2016.
Doi:10.1097/aln.0000000000000919
Carmo, L. A. S. ; Bonjour, K. ; Ueki, S. ; Neves, J. S. ; Liu, L. ; Spencer, L. A. ; Dvorak, A. M. ; Weller, P. F. ; Melo, R. C. N. . Cd63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils. Journal of leukocyte biology , v. 100, p. 391-401, 2016.
Coutinho, J. V. ; Freitas, F. F. ; Freitas, F. P. ; Porto, M. L. ; Meyrelles, S. S. ; Vasquez, E. C. ; Brandao, P. A. ; Melo, F. D.P. ; Carneiro, M. T. ; Alves, L.M. ; Silva, I. V. ; Gava, A. L. ; Gracelli, J. B. Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats. Toxicology letters , v. 16, p. 33094-33094, 2016.
Doi: 10.1016/j.toxlet.2016.08.007
Merlo, E. ; Podratz, P.L. ; Sena, G.C. ; Araújo, J.F.P. ; Lima, L.C.F. ; Alves, I.S.S. ; Souza, L.N.G. ; Pelição, R. ; Rodrigues, L.C.M. ; Brandão, P.A.A. ; Carneiro, M.T.W.D. ; Pires, R.G.W. ; Silva, C.M. ; Alarcon, T.A. ; Alves, L.M. ; Silva, I.V. ; Graceli, J.B. The environmental pollutant tributyltin chloride disrupts the hypothalamic-pituitary-adrenal axis at different levels in female rats. Endocrinology (philadelphia) , p. En.2015-1896-xxx, 2016.
Lima,L.M.; Sudo, G.Z. ; Nunes, I.K.C. ; Araujo, J.S.C. ; Silva, J. ; Trachez, M.M. ; Silva, T.F. ; Costa, F.P. ; Sudo, R.T. ; Barreiro, E.J . Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents. Drug design, development and therapy , v. Volume 10, p. 2869-2879, 2016.
Jimenez, S.E. ; Herrera, A.M. ; Olivares, R.R. ; Gonzalez, E.D. ; Torres, B.N. ; Oliveira, E. ; Romeiro, N. ; Lima, L.M. ; Palos, I. ; Rivera, G . Synthesis, biological evaluation and molecular docking of new benzenesulfonylhydrazone as potential anti-trypanosoma cruzi agents. Medicinal chemistry , v. 12, p. 1-1, 2016.
Doi: 10.2174/1573406412666160701022230
Silva, A.L. ; Magalhaes, R. ; Branco, V. ; Silva, J. ; Cruz, f. ; Marques, P. ; Ferreira, T. P. T. ; Morales, M. ; Martins, M. A. ; Rocco, P. R. M. The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma. British journal of pharmacology, v. 173, p. 1236-1247, 2016.
Alberto, A. V. P. ; Faria, R.X. ; Menezes, J. R. L. ; Surrage, A. ; Rocha, N.C. ; Ferreira, L.G.B. ; Frutuoso, V.S. ; Martins, M. A. ; Alves, L.A . Role of p2 receptors as modulators of rat eosinophil recruitment in allergic inflammation. Plos one, v. 11, p. E0145392, 2016.
Doi:10.1371/journal.pone.0145392
Ferreira, T.P.T. ; Mariano,L.L.; Bortolini, R.G.; Arantes,A.C.S.; Fernandes,A.J.; Berni, M.; Cecchinato, V.; Uguccioni, M.; Maj,R.; Barberis, A.; Silva,P.M.R.; Martins,M.A. Potential of pegylated toll-like receptor 7 ligands for controlling inflammation and functional changes in mouse models of asthma and silicosis. Frontiers in immunology (online), v. 7, p. 1, 2016.
Torres,R.C ; Magalhães,N.S; e Silva,P.M.R. ; Martins,M.A. ; Carvalho,V.F. Activation of ppar-γ reduces hpa axis activity in diabetic rats by up-regulating pi3k expression. Experimental and molecular pathology (print), v. 101, p. 290-301, 2016.
Doi: 10.1016/j.yexmp.2016.10.002
Lemes, L.F.N. ; Ramos, G.A.; Oliveira,A.S.; Silva,F.M.R. ; Couto, G.C. ; Boni, M.S. ; Guimarães,M.J.R. ; Souza,I.N.O. ; Bartolini, M.; Andrisano, V.; Nogueira,P.C.N.; Silveira,E.R.; Brand,G.D. ; Soukup, O. ; Korábeč ; Romeiro,N.C.; Castro,N.G. ; Bolognesi,M.L.; Romeiro, L.A.S. Cardanol-derived ache inhibitors: towards the development of dual binding derivatives for alzheimer's disease. European journal of medicinal chemistry, v. 108, p. 687-700, 2016.
Doi: 10.1016/j.ejmech.2015.12.024.
Petronilho, E.C. ; Rennó,M.N.; Castro,N.G.; Silva,F.M.R. ; Pinto, A.C. ; Villar, J.D.F . Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase. Journal of enzyme inhibition and medicinal chemistry (online), v. 31, p. 1-10, 2016.
Doi:10.3109/14756366.2015.1094468
Viana,J. B.N. ; Carvalho, A. R. ; Nasciutti, L. E. ; Hernandez, R.A. ; Silva, F.C. ; Souza, P. A. R. ; Romeiro, L. A. ; Sainz, J. A.G. ; Noel, F.G. ; Silva, C. L. M. New multi-target antagonists of 1a-, 1d-adrenoceptors and 5-ht1a receptors reduce human hyperplastic prostate cell growth and the increase of intraurethral pressure. The journal of pharmacology and experimental therapeutics (online) , v. 356, p. 212-222, 2016.
Costa, L.B. ; Cardoso,M.V.O.; Filho, G.B.O.; Gomes, P.A. T.O. ; Espíndola, J.W.P ; Silva, T.G. J. ; Torres, P.H.M. ; Júnior, F.P.S. ; Martin,J. ; Figueiredo, R.C.B.Q. ; Leite, A.C.L. Compound profiling and 3d-qsar studies of hydrazone derivatives with activity against intracellular trypanosoma cruzi. Bioorganic & medicinal chemistry (print) , v. 24, p. 1608-1618, 2016.
Neves, B.J. ; Dantas, R.F. ; Senger, M.R. ; Valente, W.C.G. ; Neto, J.M.R. ; Chaves, W.T. ; Kamentsky, L. ; Carpenter, A. ; Júnior, F.P.S. ; Andrade, C.H. The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery. Medchemcomm , p. 1176-1182, 2016.
Lima, J. A. ; Costa, T. W. R. ; Silva, L. L.; Miranda, A. L. P. ; Pinto, A. C . Antinociceptive and anti-inflammatory effects of a geissospermum vellosii stem bark fraction. Anais da academia brasileira de ciências (online), p. 1-12, 2016.
Doi: 10.1590/0001-3765201520140374
Lobo, B. W.P. ; Lima, C. K. F. ; Teixeira, M. S. ; Silva, Natália l.C. ; Takiya, C. M. ; Ramos, M. F.S. ; Miranda, A. L. P. ; Dellamora-ortiz, Gisela Maria . Fish oil attenuates persistent inflammatory pain in rats through modulation of tnf-α and resolvins. Life sciences (1973), v. 152, p. 30-37, 2016.
Doi: 10.1016/j.lfs.2016.03.034
Fumian, M.M. ; Motta, N.A.V. ; Maia, R. ; Fraga, C.A.M. ; Barreiro,E.J. ; Brito, F.C.F . Lassbio-1425, an analog of thalidomide, decreases triglyceride and increases hdl cholesterol levels by inhibition of tnf-α production. International journal of cardiology (print) , v. 202, p. 497-499, 2016.
Doi: 10.1016/j.ijcard.2015.09.071
Rodrigues, D.A. ; Silva,G.F. ; Ferreira, A.C.S. ; Fernandes, R.A.. ; Kwee, J.K. ; Sant’anna, C.M. R. ; Ionta, M. ; Fraga, C.A.M. . Design, synthesis, and pharmacological evaluation of novel n -acylhydrazone derivatives as potent histone deacetylase 6/8 dual inhibitors. Journal of medicinal chemistry , v. 59, p. 655-670, 2016.
Doi:10.1021/acs.jmedchem.5b01525
Guedes, I.A. ; Freitas, R.H. C. N. ; Cordeiro, N.M. ; Nascimento, T.S.; Valerio, T.S. ; Fernandes, P.D.. ; Dardenne, L. ; Fraga, C.A.M. Lassbio-1829 hydrochloride: development of a new orally active n -acylhydrazone ikk2 inhibitor with anti-inflammatory properties. Chemmedchem (print) , v. 11, p. 234-244, 2016.
Senger, M.R. ; Fraga, C.A.M. ; Dantas, R.F.. ; Silva, F.P. Filtering promiscuous compounds in early drug discovery: is it a good idea?. Drug discovery today , v. 21, p. 868-872, 2016.
Doi:10.1016/j.drudis.2016.02.004
Antonio, C.B. ; Betti, A.H.. ; Herzfeldt, V ; Barreiro,E.J.. ; Fraga, C.A.M. ; Rates, S.M.K. Lassbio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model. Behavioural pharmacology , v. 27, p. 339-349, 2016.
Doi:10.1097/fbp.0000000000000200
Cordeiro, N.M. ; Freitas, R.H. C. N. ; Fraga,C.A. M. ; Fernandes, P.D. Discovery of novel orally active tetrahydro-naphthyl-n-acylhydrazones with in vivo anti-tnf-α effect and remarkable anti-inflammatory properties. Plos one , v. 11, p. E0156271, 2016.
Oliveira, S. D. S. ; Oliveira, N. F. ; Fernandes, J. R. M ; Savio, l. E. ; Ornelas, F. G. ; Ferreira, Z. S. ; Cilva, R. C. ; Silva, C.L.M . Increased expression of ntpdases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through p2y1 receptors. Vascular pharmacology , v. 82, p. 66-72, 2016.
F.G. ; Viana, J. B.N ; Romeiro, L.A.S. ; Silva, R.O.. ; Lemes, l. ; Oliveira, A. S. ; Giorno, T. ; Fernandes, P. D. ; Silva, C.L.M . Adme studies and preliminary safety pharmacology of ldt5, a lead compound for the treatment of benign prostatic hyperplasia. Brazilian journal of medical and biological research (on line) , v. 49, p. E5542, 2016.
Silva, C.L.M. Purinergic signaling in schistosomal infection. Biomedical journal (print) , v. 50, p. 1-10, 2016.
Dias, L.C. ; Vieira, A.S. ; Barreiro, E.J. The total synthesis of calcium atorvastatin. Organic & biomolecular chemistry , v. 14, p. 2291-2296, 2016.
Silva, J.D. ; Oliveira, G.P. ; Samary, C.S. ; Araujo, C.C. ; Padilha, G.A. ; Filho, F.C.S. ; Silva, R.T. ; Lamas, M.E. ; Morales, M.M. ; Capelozzi, V.L. ; Silva, V.M. ; Lima, L.M. ; Barreiro, E.J. ; Diaz, B.L. ; Pelosi, P. ; Silva, P.L. ; Garcia, C.S.N.B. ; Rocco, P.R.M . Respiratory and systemic effects of lassbio596 plus surfactant in experimental acute respiratory distress syndrome. Cellular physiology and biochemistry , v. 38, p. 821-835, 2016.
Thota, S. ; Vallala, S. ; Yerra, R. ; Rodrigues, D.A. ; Raghavendra, N.M. ; Barreiro, E.J. Synthesis, characterization, dna binding, dna cleavage, protein binding and cytotoxic activities of ru(ii) complexes. International journal of biological macromolecules , v. 82, p. 663-670, 2016.
Doi:10.1016/j.ijbiomac.2015.09.045
Alves, M. A. ; Nirma, C. ; Moreira, M. M. ; Soares, R. O. ; Pascutti, P. G. ; Noël, F.G ; Costa, P. R. R. ; Sant'anna, C. M. R. ; Barreiro, E. J. ; Lima, L. M. ; Tinoco, L. W. Non-competitive inhibitor of nucleoside hydrolase from leishmania donovani identified by fragment-based drug discovery. Rsc advances , v. 6, p. 87738-87744, 2016.